Changes in peripapillary retinal nerve fiber layer thickness in chronic glaucoma and non-glaucoma patients after phacoemulsification cataract surgery

  • Olivia P. Perdana Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Andi A. Victor Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Virna D. Oktarina Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Joedo Prihartono Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta
DOI: https://doi.org/10.13181/mji.v24i4.1181
Keywords: cataract, chronic glaucoma, phacoemulsification, retinal nerve fiber layer, visual field
Abstract viewed: 1783 times
PDF downloaded: 1136 times

Abstract

Background: Phacoemulsification is a common cataract operation nowadays. During phacoemulsification, variation in intraocular pressure (IOP) may occur, which might change the retinal nerve fiber layer (RNFL) thickness. This study was aimed to evaluate the change in peripapillary RNFL thickness and mean deviation (MD) of visual field after phacoemulsification in chronic primary glaucoma and non-glaucoma patients.

Methods: Cohort prospective study was done on 26 patients (13 chronic glaucoma eyes and 13 non-glaucoma eyes) who underwent phacoemulsification. The changes in peripapillary RNFL thickness and MD of visual field were measured as the primary outcome. Comparison between pre- and post-surgery was analyzed with paired t-test, while unpaired t-test was used for comparison between groups.

Results: There were no significant changes in RNFL thickness on both groups. Average RNFL thickness in glaucoma group before and after phacoemulsification were 94.9±20.0 μm and 99.1±21.3 μm, respectively (p>0.05). Average RNFL thickness in non-glaucoma group were 100.2±11.1 μm and 101.7±6.8 μm, respectively (p>0.05). Glaucoma patients yielded decreasing mean deviation (MD) of visual field, but it was not statistically significant (p=0.071). In contrast, the MD of visual field after surgery was significantly increased in non-glaucoma group (p=0.005).

Conclusion: Phacoemulsification tended to increase peripapillary RNFL thickness in glaucoma or non-glaucoma patients. The visual field tended to decrease in glaucoma patients, but was significantly increased in non-glaucoma patients.

References

  1. Levin LA. Pathophysiology of the progressive optic neuropathy of glaucoma. Ophthalmol Clin North Am. 2005;18(3):355–64. http://dx.doi.org/10.1016/j.ohc.2005.05.010

  2. Rao HL, Babu JG, Addepalli UK, Senthil S, Garudadri CS. Retinal nerve fiber layer and macular inner retina measurements by spectral domain optical coherence tomograph in Indian eyes with early glaucoma. Eye (Lond). 2012;26(1),133–9. http://dx.doi.org/10.1038/eye.2011.277

  3. Sung KR, Kim DY, Park SB, Kook MS. Comparison of retinal nerve fiber layer thickness measured by Cirrus HD and Stratus optical coherence tomography. Ophthalmology. 2009;116(7):1264–70. http://dx.doi.org/10.1016/j.ophtha.2008.12.045

  4. Schuman JS, Hee MR, Puliafito CA, Wong C, Pedut-Kloizman T, Lin CP, et al. Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography. Arch Ophthalmol. 1995;113(5):586–96. http://dx.doi.org/10.1001/archopht.1995.01100050054031

  5. American Academy of Ophthalmology. Fundamentals and principles of ophthalmology: basic and clinical science course. San Francisco: American Academy of Ophthalmology; 2006–2007.

  6. Chen D, Zhu J, Li J, Ding XX, Lu F, Zhao YE. Effect of simulated dynamic intraocular pressure on retinal thickness measured by optical coherence tomography after cataract surgery. Int J Ophthalmol. 2012;5(6):687–93. http://dx.doi.org/10.3980/j.issn.2222-3959.2012.06.07

  7. Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol. 2006;90(3):262-7. http://dx.doi.org/10.1136/bjo.2005.081224

  8. Faiqoh M. Karakteristik pasien di divisi glaukoma poliklinik mata Rumah Sakit Cipto Mangunkusumo tahun 2001–2010 Jakarta: Indonesia; 2011. Indonesian

  9. Wang YX, Xu L, Yang H, Jonas JB. Prevalence of glaucoma in North China: the Beijing eye study. Am J Ophthalmol. 2010;150(6):917–24. http://dx.doi.org/10.1016/j.ajo.2010.06.037

  10. Giangiacomo A, Coleman AL. The epidemiology of glaucoma In: Grehn F, Stamper R, editors. Glaucoma. Heidelberg: Springer; 2009. p. 13–21. http://dx.doi.org/10.1007/978-3-540-69475-5_2

  11. Liu X, Zhong YM, Xiao H, Huang JJ, Kong XY. The damage patterns of retinal nerve fiber layer in acute and chronic intraocular pressure elevation in primary angle closure glaucoma. Eye Sci. 2011;26(3):154–60. http://dx.doi.org/ 10.3969/j.issn.1000-4432.2011.03.006.

  12. Tsai JC, Lin PW, Teng MC, Lai IC. Longitudinal changes in retinal nerve fiber layer thickness after acute primary angle closure measured with optical coherence tomography. Invest Ophthalmol Vis Sci. 2007;48(4):1659–64. http://dx.doi.org/10.1167/iovs.06-0950

  13. Schuman JS. Spectral domain optical coherence tomography for glaucoma (An AOS Thesis). Trans Am Ophthalmol Soc. 2008;106:426–58.

  14. Yoles E, Schwartz M. Potential neuroprotective therapy for glaucomatous optic neuropathy. Surv Ophthalmol. 1998;42(4):367–72. http://dx.doi.org/10.1016/S0039-6257(97)00123-9

  15. Pardianto G, Moeloek N, Reveny J, Wage S, Satari I, Sembiring R, et al. Retinal thickness changes after phacoemulsification. Clin Ophthalmol. 2013;7:2207–14. http://dx.doi.org/10.2147/OPTH.S53223

  16. Lee DW, Kim JM, Park KH, Choi CY, Cho JG. Effect of media opacity on retinal nerve fiber layer thickness measurements by optical coherence tomography. J Ophthalmic Vis Res. 2010;5(3):151–7.

  17. Dada T, Behera G, Agarwal A, Kumar S, Sihota R, Panda A. Effect of cataract surgery on retinal nerve fiber layer thickness parameters using scanning laser polarimetry (GDxVCC). Indian J Ophthalmol: 2010;58(5):389–94. http://dx.doi.org/10.4103/0301-4738.67048

  18. Gazzard G, Foster PJ, Devereux JG, Oen F, Chew P, Khaw PT, et al. Intraocular pressure and visual field loss in primary angle closure and primary open angle glaucomas. Br J Ophthalmol. 2003;87(6):720–5. http://dx.doi.org/10.1136/bjo.87.6.720

  19. Cheung CY, Leung CK, Lin D, Pang CP, Lam DS. Relationship between retinal nerve fiber layer measurement and signal strength in optical coherence tomography. Ophthalmology. 2008;115(8):1347–51. http://dx.doi.org/10.1016/j.ophtha.2007.11.027

Published
2015-12-31
How to Cite
1.
Perdana OP, Victor AA, Oktarina VD, Prihartono J. Changes in peripapillary retinal nerve fiber layer thickness in chronic glaucoma and non-glaucoma patients after phacoemulsification cataract surgery. Med J Indones [Internet]. 2015Dec.31 [cited 2024Apr.25];24(4):221-7. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/1181
Issue
Vol. 24 No. 4 (2015): December
Section
Clinical Research

Copyright (c) 2015 Olivia P. Perdana, Andi A. Victor, Virna D. Oktarina, Joedo Prihartono

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with Medical Journal of Indonesia agree to the following terms:

  1. Authors retain copyright and grant Medical Journal of Indonesia right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial License that allows others to remix, adapt, build upon the work non-commercially with an acknowledgment of the work’s authorship and initial publication in Medical Journal of Indonesia.
  2. Authors are permitted to copy and redistribute the journal's published version of the work non-commercially (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Medical Journal of Indonesia.

Most read articles by the same author(s)