Clinical characteristics of acute respiratory distress syndrome survived patients at a tertiary hospital in Jakarta

  • Zulkifli Amin Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Fitriana N. Rahmawati Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Chrispian O. Mamudi Department of Internal Medicine, Siloam General Hospital, Manado
  • Astrid P. Amanda Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
DOI: https://doi.org/10.13181/mji.v26i1.1470
Keywords: ARDS, clinical profile, survivors
Abstract viewed: 1790 times
PDF downloaded: 1040 times
HTML downloaded: 92 times
EPUB downloaded: 102 times

Abstract

Background: While a good deal of research on characteristic the different characteristics between surviving and dying patient with ARDS has been conducted globally, such research is scarce in developing countries. This study aimed to obtain clinical profile of ARDS survivors during hospitalization.

Methods: This was a prospective, observational study conducted at a tertiary hospital in Jakarta from October 2015 to April 2016. Primary data was collected from ARDS patients based on Berlin Definition admitted to emergency room, ICU, HCU, ICCU, and all other wards. The patients were followed until they discharged. We only included survivors on the analysis. Descriptive analysis was done using SPSS 21.0.

Results: A total of 43 patients were survived during study period. The majority were below 65 years of age (69.8%) and were male (53.5%). ARDS was mainly mild in severity (62.8%) and early onset (55.8%). Sepsis was the most common causes of ARDS (97.7%). Most of the patients had comorbidities (74.4%). Majority of the patients had APACHE II score <20 (77.3%) with mean 15.6±4.8. The mean of albumin was 2.9±0.6 and the median of procalcitonin was 3 (0.1-252.3).

Conclusion: The clinical profile of ARDS survivors in our study were mostly similar with other studies conducted in developed and other developing countries.

References

  1. Koh Y. Update in acute respiratory distress syndrome. J Intensive Care. 2014;2(1):2. https://doi.org/10.1186/2052-0492-2-2

  2. Sheu CC, Gong MN, Zhai R, Chen F, Bajwa EK, Clardy PF, et al. Clinical characteristics and outcomes of sepsis-related vs non-sepsis-related ARDS. Chest. 2010;138(3):559–67. https://doi.org/10.1378/chest.09-2933

  3. Pierakos C, Vincent JL. The changing pattern of acute respiratory distress syndrome over time: a comparison of two periods. Eur Respir J. 2012;40(3):589–95. https://doi.org/10.1183/09031936.00130511

  4. Estenssoro E, Dubin A, Laffaire E, Canales H, Sáenz G, Moseinco M, et al. Incidence, clinical course, and outcome in 217 patients with acute respiratory distress syndrome. Crit Care Med. 2002;30(11):2450–6. https://doi.org/10.1097/00003246-200211000-00008

  5. Stapleton RD, Wang BM, Hudson LD, Rubenfeld GD, Caldwell ES, Steinberg KP. Causes and timing of death in patients with ARDS. Chest. 2005;128(2):525–32. https://doi.org/10.1378/chest.128.2.525

  6. Ranieri V, Rubenfeld G, Thompson BT, Ferguson ND, Caldwell E, Fan E, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA. 2012;307(23):2526–33. DOI: 10.1001/jama.2012.5669

  7. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: A severity of disease classification system. Crit Care Med. 1985;13(10):818–29. https://doi.org/10.1097/00003246-198510000-00009

  8. Sharif N, Irfan M, Husain J, Khan J. Factors associated within 28 days in-hospital mortality of patients with acute respiratory distress syndrome. Biomed Res Int. 2013;2013(564547):5. https://doi.org/10.1155/2013/564547

  9. Zilberberg MD, Epstein SK. Acute lung injury in the medical ICU comorbid conditions, age, etiology, and hospital outcome. Am J Respir Crit Care Med. 1998;157(4Pt1):1159–64. https://doi.org/10.1164/ajrccm.157.4.9704088

  10. Moss M, Mannino D. Race and gender differences in acute respiratory distress syndrome deaths in the United States: an analysis of multiple-cause mortality data (1979–1996). Crit Care Med. 2002;30(8):1679–85. https://doi.org/10.1097/00003246-200208000-00001

  11. Venet C, Guyomarc'h S, Pingat J, Michard C, Laporte S, Bertrand M, et al. Prognostic factors in acute respiratory distress syndrome: a retrospective multivariate analysis including prone positioning in management strategy. Intensive Care Med. 2003;29(9):1435–41. https://doi.org/10.1007/s00134-003-1856-2

  12. Bhadade R, de Souza RA, Harde MJ, Khot A. Clinical characteristics and outcomes of patients with acute lung injury and ARDS. J Postgrad Med. 2011;57(4):268-90. https://doi.org/10.4103/0022-3859.90077

  13. Tseng CC, Fang WF, Leung SY, Chen HC, Chang YC, Wang CC, et al. Impact of serum biomarkers and clinical factors on intensive care unit mortality and 6-month outcome in relatively healthy patients with severe pneumonia and acute respiratory distress syndrome. Dis Markers. 2014;2014(804654):1–9. https://doi.org/10.1155/2014/804654

  14. Liao KM, Chen CW, Hsiue TR, Lin WC. Timing of acute respiratory distress syndrome onset is related to patient outcome. J Formos Med Assoc. 2009;108(9):694–703. https://doi.org/10.1016/S0929-6646(09)60392-2

  15. Erickson SE, Martin GS, Davis JL, Matthay MA, Eisner MD. Recent trends in acute lung injury mortality: 1996-2005. Crit Care Med. 2009;37(5):1574–9. https://doi.org/10.1097/CCM.0b013e31819fefdf

  16. Saleh A, Ahmed M, Sultan I, Abdel-lateif A. Comparison of the mortality prediction of different ICU scoring systems (APACHE II and III, SAPS II, and SOFA) in a single-center ICU subpopulation with acute respiratory distress syndrome. Egyptian J Chest Dis Tuberculosis. 2015;64(4):843–8. https://doi.org/10.1016/j.ejcdt.2015.05.012

  17. Luecke T, Muench E, Roth H, Friess U, Paul T, Kleinhuber K, et al. Predictors of mortality in ARDS patients referred to a tertiary care centre: a pilot study. Eur J Anaesth. 2006;23(5):403–10. https://doi.org/10.1017/S0265021505001870

  18. Tang L, Zhao Y, Wang D, Deng W, Li C, Li Q, et al. Endocan levels in peripheral blood predict outcomes of acute respiratory distress syndrome. Hindawi. 2014;201(652180):180–8. https://doi.org/10.1155/2014/625180

Published
2017-05-16
How to Cite
1.
Amin Z, Rahmawati FN, Mamudi CO, Amanda AP. Clinical characteristics of acute respiratory distress syndrome survived patients at a tertiary hospital in Jakarta. Med J Indones [Internet]. 2017May16 [cited 2024Apr.20];26(1):35-9. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/1470
Issue
Vol. 26 No. 1 (2017): March
Section
Clinical Research

Copyright (c) 2017 Zulkifli Amin, Fitriana N. Rahmawati, Chrispian O. Mamudi, Astrid P. Amanda

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with Medical Journal of Indonesia agree to the following terms:

  1. Authors retain copyright and grant Medical Journal of Indonesia right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial License that allows others to remix, adapt, build upon the work non-commercially with an acknowledgment of the work’s authorship and initial publication in Medical Journal of Indonesia.
  2. Authors are permitted to copy and redistribute the journal's published version of the work non-commercially (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Medical Journal of Indonesia.