@article{Rahmayunita_Jacoeb_Novianto_Indriatmi_Rihatmadja_Pusponegoro_2018, title={A double-blind randomized controlled trial of topical <em>Curcuma xanthorrhiza</em> Roxb. on mild psoriasis: clinical manifestations, histopathological features, and K6 expressions}, volume={27}, url={http://mji.ui.ac.id/journal/index.php/mji/article/view/2511}, DOI={10.13181/mji.v27i3.2511}, abstractNote={<p><strong>Background:</strong> <em>Curcuma xanthorrhiza</em> Roxb. exerts its anti-inflammatory effects by reducing the concentration of IL-6, IL-8, and phosphorylase kinase, which has role in keratinocyte proliferation. Our study aimed to evaluate the efficacy of <em>C. xanthorrhiza</em> in psoriasis.<br /><br /><strong>Methods:</strong> From 18 to 59 year-old patients with mild psoriasis, 2 similar lesions were selected. The severity assessment was based on the psoriasis area severity index (PASI), Trozak score, and K6 expression. Using a double-blinded randomized method, lesion was treated with 1% <em>C. xanthorrhiza</em> ointment vs placebo for 4 weeks. The results were analyzed by the chi-square test using STATATM V.12 software (Stata Corp.).<br /><br /><strong>Results:</strong> The study was conducted in 2010 to 2012 with 17 subjects participated. The median of PASI score were reduced significantly in both lesions, either treated with 1% <em>C. xanthorrhiza</em> ointment vs placebo; however when compared between the group, it was not significant (p=0.520). The Trozak score were reduced in lesions treated with 1% <em>C. xanthorrhiza</em> ointment; but it was not significant (p = 0.306). In lesions treated with placebo, the Trozak score was increased significantly. The difference of Trozak score between lesions treated with <em>C. xanthorrhiza</em> and placebo was significant (p=0.024). There was no significant difference of K6 expression in lesions treated with 1% <em>C. xanthorrhiza</em> ointments or placebo as well as on the difference of mean values of K6 expression between the group (p=0.827).</p><p><strong>Conclusion:</strong> Based on the results, 1% <em>C. xanthorrhiza</em> ointment is effective treatment option for mild psoriasis, but longer follow-up period is suggested to confirm this results. <em>C. xanthorrhiza</em> ointment is safe for topical administration as there were no side effects reported in this study.</p&gt;}, number={3}, journal={Medical Journal of Indonesia}, author={Rahmayunita, Githa and Jacoeb, Tjut N.A. and Novianto, Endi and Indriatmi, Wresti and Rihatmadja, Rahadi and Pusponegoro, Erdina H.D.}, year={2018}, month={Oct.}, pages={178-84} }