@article{Sartika_Lukito_Wijaya_2009, title={Adiponectin, total anti-oxidant status, and high sensitivity C-reactive protein in Indonesian men with metabolic syndrome}, volume={18}, url={http://mji.ui.ac.id/journal/index.php/mji/article/view/369}, DOI={10.13181/mji.v18i4.369}, abstractNote={<p><strong>Aim</strong> To examine biochemical markers of adiponectin, total anti-oxidant status (TAOS) and high sensitvity C-reactive protein (<em>hs</em>CRP) in individuals with and without metabolic syndrome (MetS).</p> <p><strong>Methods</strong> A cross-sectional study on 36 non-MetS and 36 MetS subjects was undertaken in Jakarta. Measured indicators were adiponectin, TAOS and <em>hs</em>CRP, apart from weight, height, waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), and fasting blood glucose (FBG). Odds ratio (OR) of adiponectin, TAOS and <em>hs</em>CRP were calculated to assess risk for the development of MetS. Median values were determined as cut-offs to define high and low values of each parameter. Relationships between adiponectin, TAOS and <em>hs</em>CRP with WC were analyzed by using Spearman correlation analysis, and the contributions of all indicators to the development of MetS were analyzed by using logistic regression.</p> <p><strong>Results</strong>: Adiponectin dan <em>hs</em>CRP differed significantly between non MetS and MetS subjects (4.2 + 1.4 vs 3.1 + 1.0 ug/mL) dan (0.97 + 0.92 vs 3.35 + 3.43 mg/L) (p &lt; 0.01), but no significant difference was found in TAOS (1.24 + 0.1 vs 1.28 + 0.2 mmol/L). Adiponectin associated negatively with WC (r<sub>s</sub>=&nbsp; -0.436; p &lt; 0.01), while TAOS and <em>hs</em>CRP associated positively with WC (r<sub>s</sub>= 0.286, p = 0.02 and r<sub>s</sub>= 0.597, p &lt; 0.01). The odds ratios (ORs) of adiponectin and <em>hs</em>CRP for the development of MetS were 4 (p = 0.01) and ~6,8 (p &lt; 0.01), respectively; while the risk of subjects with adiponectin-hsCRP ratio of ≤ 2.31 to develop MetS was 25 times (p &lt; 0.01) those with adiponectin-<em>hs</em>CRP ratio &gt; 2.31.</p> <p><strong>Conclusion</strong> The use of adiponectin-<em>hs</em>CRP ratio increases the predictive power for the occurrence of MetS by 4-6 times the predictive power of adiponectin or <em>hs</em>CRP alone. <em><strong>(Med J Indones 2009; 18: 262-8)</strong></em></p&gt;}, number={4}, journal={Medical Journal of Indonesia}, author={Sartika, Cynthia R. and Lukito, Widjaja and Wijaya, Andi}, year={2009}, month={Nov.}, pages={262-8} }