@article{Indarti_Aziz_Sutrisna_Siregar_Suryawati_Harahap_2010, title={Demographic characteristics, risk factors and immunocytochemistry of p16INK4a, Ki-67, MCM5, and survivin as predictors for the progress of cervical precancer lesion}, volume={19}, url={http://mji.ui.ac.id/journal/index.php/mji/article/view/398}, DOI={10.13181/mji.v19i3.398}, abstractNote={<p><strong>Aim</strong> To identify the predictive factors and biomarkers in the progression of cervical precancer lesion or CervicalÂ&nbsp;Intraepithelial Neoplasia (CIN).</p> <p><strong>Methods</strong> The study was conducted from August 2007 to September 2008. Design of the study was case-control with stratifications of test dose response. The cases were patients with CIN. Control patients were non CIN patients. Bivariate analysis followed by multivariate analysis was conducted.</p> <p><strong>Results</strong> There were 130 patients, consisting of 124 CIN patients divided into CIN 1, CIN 2 and CIN 3, with the following numbers of patients: 30, 41, and 33, respectively and 26 patients without CIN (non CIN). Bivariate analysis showed that age &lt; 41 years, education ≥13 years, sexual partner ≥2, first sexual relationship at age &lt; 22 years, smoking, the presence of sexuallly transmitted infections, positive HPV DNA, high p<sup>16INK4a</sup>, Ki-67, MCM5 and Survivin expression constituted independent variables for the occurrence of CIN with P value of &lt; 0.05. However, on multivariate analysis, independent variables that emerged were age, education ≥13 years, sexual partner ≥2 persons, positive HPV DNA, and over expression of p16INK4a, Ki-67 and Survivin that showed a P value of &lt; 0.005.</p> <p><strong>Conclusion</strong> Younger ages, education age ≥13 years, sexual partner ≥2 persons, positive HPV DNA, high p<sup>16INK4a</sup>, Ki-67 and Survivin expression constituted the risk factors for the occurrence of the progress of CIN, and was used in the equation to predict the progress of cervical precancer lesion. <em><strong>(Med J Indones 2010;19:147-53)</strong></em></p&gt;}, number={3}, journal={Medical Journal of Indonesia}, author={Indarti, Junita and Aziz, Mohammad F. and Sutrisna, Bambang and Siregar, Nuryati C. and Suryawati, Bethy and Harahap, Alida}, year={2010}, month={Aug.}, pages={147-53} }