@article{Effendi_Pitoyo_Sinto_Suwarto_2022, title={Procalcitonin prognostic value in predicting mortality among adult patients with sepsis due to Gram-negative bacteria}, volume={31}, url={http://mji.ui.ac.id/journal/index.php/mji/article/view/5864}, DOI={10.13181/mji.oa.225864}, abstractNote={<p><strong>BACKGROUND</strong> Sepsis is a leading cause of mortality and morbidity globally. Gram-negative bacteremia was reported to have a high risk of septic shock and poor prognosis. This study aimed to evaluate the role of procalcitonin in predicting mortality in patients with sepsis due to Gram-negative bacteria.</p> <p><strong>METHODS</strong> This was a retrospective cohort study performed based on medical records and sepsis registry of Tropical and Infectious Disease Division, Department of Internal Medicine, Cipto Mangunkusumo Hospital. The inclusion criteria were patients aged ≥18 years diagnosed with sepsis due to Gram-negative bacteria based on blood culture on admission and hospitalized between March 2017 and October 2020. Data taken from medical records included subjects’ characteristics, laboratory parameters, and 28-day mortality outcomes during hospitalization. Receiver operating characteristic was used to determine the area under the curve (AUC) of procalcitonin and its accuracy.</p> <p><strong>RESULTS</strong> A total of 128 patients were eligible. The cumulative survival of patients with Gram-negative bacteremia was 48.4% (standard error 0.96%). The AUC of procalcitonin to predict mortality was 0.45 (95% confidence interval 0.36–0.54). <em>Escherichia coli</em> was the predominant microorganism in blood culture (n = 38, 29.7%).</p> <p><strong>CONCLUSIONS</strong> Procalcitonin has a poor performance in predicting mortality of patients with sepsis due to Gram-negative bacteria.</p&gt;}, number={1}, journal={Medical Journal of Indonesia}, author={Effendi, Bonita and Pitoyo, Ceva Wicaksono and Sinto, Robert and Suwarto, Suhendro}, year={2022}, month={Apr.}, pages={50-5} }