@article{Ferdiana_Ramlan_Soenarto_Alatas_2022, title={Thromboelastographic method for early decision on anticoagulant therapy in moderate to severe COVID-19 patients}, volume={31}, url={http://mji.ui.ac.id/journal/index.php/mji/article/view/5890}, DOI={10.13181/mji.oa.225890}, abstractNote={<p><strong>BACKGROUND</strong> Coagulopathy is a serious COVID-19 complication that requires rapid diagnosis and anticoagulation. This study aimed to determine the role of coagulation examination using thromboelastography (TEG) on the decision-making time of anticoagulant therapy in COVID-19 patients and its clinical outcomes.</p> <p><strong>METHODS</strong> A prospective observational study was conducted in Cipto Mangunkusumo Hospital, Indonesia, from October 2020 to March 2021. We consecutively recruited moderate and severe COVID-19 patients in the high and intensive care units. Turnaround time, time to anticoagulant therapy decision, and clinical outcomes (length of stay and 30-day mortality) were compared between those who had a TEG examination in addition to the standard coagulation profile examination (thrombocyte count, PT, APTT, D-dimer, and fibrinogen) and those who had only a standard coagulation profile laboratory examination.</p> <p><strong>RESULTS</strong> Among 100 moderate to severe COVID-19 patients recruited, 50 patients had a TEG examination. The turnaround time of TEG was 45 (15–102) min versus 82 (19–164) min in the standard examination (<em>p</em>&lt;0.001). The time to decision was significantly faster in the TEG group than the standard group (75 [42–133] min versus 184 [92–353] min, <em>p</em>&lt;0.001). The turnaround time was positively correlated with time to decision (r = 0.760, <em>p</em>&lt;0.001). However, TEG did not improve clinical outcomes such as length of stay (10.5 [3–20] <em>versus</em> 9 [2–39] days) and 30-day mortality (66% <em>versus</em> 64%).</p> <p><strong>CONCLUSIONS</strong> The TEG method significantly enables quicker decision-making time for moderate to severe coagulation disorder in COVID-19 patients.</p&gt;}, number={2}, journal={Medical Journal of Indonesia}, author={Ferdiana, Komang Ayu and Ramlan, Andi Ade Wijaya and Soenarto, Ratna Farida and Alatas, Anas}, year={2022}, month={Jul.}, pages={96-101} }