@article{Riasanti_Putera_Jessica_Waliyuddin_Tagar_Karlina CH_Aziza_Susiyanti_Edwar_Sitompul_La Distia Nora_2023, title={Interferon-gamma release assay and chest X-ray to classify intraocular tuberculosis among clinically undifferentiated uveitis}, volume={31}, url={http://mji.ui.ac.id/journal/index.php/mji/article/view/6324}, DOI={10.13181/mji.oa.226324}, abstractNote={<p><strong>BACKGROUND</strong> Tuberculosis (TB) is a common cause of intraocular inflammation in Indonesia. As no accurate biomarker can confirm the diagnosis, ophthalmologists often rely on systemic findings, such as tuberculin skin test, interferon-gamma release assay (IGRA), and chest X-ray (CXR) for TB suspicion. This study aimed to evaluate IGRA and CXR in classifying intraocular TB among patients with a clinically undifferentiated cause of uveitis.</p> <p><strong>METHODS</strong> This cross-sectional study included 116 patients (a total of 163 affected eyes) with a clinically undifferentiated cause of uveitis. IGRA and CXR were performed as part of the workup. Data on visual acuity, anterior chamber inflammation grade, and anatomical classification of uveitis were recorded. As there were no confirmed ocular tuberculosis (OTB) in our cases, eyes were classified into probable OTB, possible OTB, and unclassified.</p> <p><strong>RESULTS</strong> Overall, 93 patients (80.2%) with a clinically undifferentiated cause of uveitis had positive IGRA, whereas 10 (8.6%) had CXR results suggestive of TB. More than one-third of the patients were blind (visual acuity &lt;3/60), and panuveitis was the commonest anatomical classification. A trend was identified in patients with panuveitis, who often showed ≥2+ cell anterior chamber inflammation (<em>p</em> for trend = 0.023), according to OTB criteria (probable OTB = 3/4, 75.0%; possible OTB = 44/67, 65.7%; unclassified = 2/9, 22.2%). Furthermore, the clinically undifferentiated uveitis cases were eligible to be stratified into probable (8.6%) and possible (75.0%) OTB categories after IGRA and CXR examinations.</p> <p><strong>CONCLUSIONS</strong> The combination of IGRA and CXR is valuable for classifying and diagnosing TB-related uveitis. A multidisciplinary approach is essential when the cause of uveitis is unknown.</p&gt;}, number={4}, journal={Medical Journal of Indonesia}, author={Riasanti, Mei and Putera, Ikhwanuliman and Jessica, Priscilla and Waliyuddin, Muhammad Zakiy and Tagar, Faiz Alwan and Karlina CH, Andini and Aziza, Yulia and Susiyanti, Made and Edwar, Lukman and Sitompul, Ratna and La Distia Nora, Rina}, year={2023}, month={Jan.}, pages={225-31} }