TY - JOUR AU - T. Z. Jacoeb AU - C. Nuruliza AU - N. Chaniago PY - 2005/08/01 Y2 - 2024/03/29 TI - Cytosolic estrogen and progesterone receptor content in the endometriotic tissues and endometrium in women with and without endometriosis JF - Medical Journal of Indonesia JA - Med J Indones VL - 14 IS - 3 SE - Basic Medical Research DO - 10.13181/mji.v14i3.185 UR - http://mji.ui.ac.id/journal/index.php/mji/article/view/185 AB - In order to have a profile of cytosolic estrogen and progesterone receptors in either endometriotic tissue or endometrium in patients with and without endometriosis a cross-sectional study was  performed  involving  43  infertile women. They consisted of 31 (72.09%) endometriosis and 12 (27.91%) non-endometriosis cases; their average age was 32 ±4 years and 32  ±3 years respectively, with the average  length  of  menstrual  cycle  31  ±8  days  and  29  ±1  days  respectively.  The endometriotic tissue was obtained by excision during ope-rative laparoscopy procedure, while the endometrium was obtained  by  biopsy following hysteroscopy  procedure.  These procedures  were  conducted  within  the  periovulatory  period  (on  Day  13-18  of  the  cycle).The  sex  steroid  receptor  content  in  the cytosol  was  measured  quantitatively  using enzyme-immunoassaymethod,  and  calculated  as  sex  steroid  receptor/cytosol  protein (fmol/ml  cytosol).  It  was  found  that  the  average cytosolic estrogen  receptor concentration  in  the  respective  tissues  were 512.99fmol/ml  in  the  endometriotic  ovary compared  with  2369.17  in  normal  ovary and  632.18  fmol/ml  in  the  endometriotic  peritoneum compared  with  9607.61  fmol/ml  in  normal  peritoneum;while 99.28  fmol/ml and 608.33fmol/ml in the endometrium of women with endometriosis and those without endometriosis respectively. The average cytosolic progesterone receptor concentration found in the respective  tissues  were 50.64fmol/ml  in  the  endometriotic  ovary compared  with  6469.42  fmol/ml  in  normal  ovary and1631.40 fmol/ml  in  endometriotic  peritoneum compared with 12466.99 in normal peritoneum, while21.26 fmol/ml and 599.61fmol/ml in the endometrium  of  women  with  endometriosis  and  those  without  endometriosis  respectively.  There  is  no  significant difference in the  receptor concentration  between  each  tissue  according  to  its  topographic  origin. However,  this  result  may  assume  that  the  responsivity  on  hormonal treatment in endometriosis cases willdepend on the cytosolic sex steroid receptor content in the sick tissues, and the peritoneal lesions will possibly give better response than those in other sites. A further clinical trial is necessary. (Med J Indones 2005; 14: 133-41) ER -