TY - JOUR AU - Bashar Adi Wahyu Pandhita AU - Deliana Nur Ihsani Rahmi AU - Nielda Kezia Sumbung AU - Bernardino Matthew Waworuntu AU - Regina Puspa Utami AU - Melva Louisa AU - Vivian Soetikno PY - 2019/10/04 Y2 - 2024/03/28 TI - A glance at molecular mechanisms underlying cisplatin-induced nephrotoxicity and possible renoprotective strategies: a narrative review JF - Medical Journal of Indonesia JA - Med J Indones VL - 28 IS - 3 SE - Review Article DO - 10.13181/mji.v28i3.2690 UR - http://mji.ui.ac.id/journal/index.php/mji/article/view/2690 AB - Cisplatin is a platinum-based drug that is usually used for the treatment of many carcinomas. However, it comes with several devastating side effects, including nephrotoxicity. Cisplatin toxicity is a very complex process, which is exacerbated by the accumulation of cisplatin in renal tubular cells via passive diffusion and transporter-mediated processes. Once cisplatin enters these cells, it induces the formation of reactive oxygen species that cause cellular damage, including DNA damage, inflammation, and eventually cell death. On a small scale, these damages can be mitigated by cellular antioxidant defense mechanism. However, on a large scale, such as in chemotherapy, this defense mechanism may fail, resulting in nephrotoxicity. The current article reviews the molecular mechanisms underlying cisplatin-induced nephrotoxicity and possible renoprotective strategies to determine novel therapeutic interventions for alleviating this toxicity. ER -