Medical Journal of Indonesia 2024-01-02T11:01:41+07:00 Med J Indones Open Journal Systems <p><a href="">ABOUT JOURNAL</a> | <a href=";hl=en" target="_blank&quot;">CITATIONS</a> | <a href="">STATISTIC</a> | <a href="/journal/index.php/mji/submit">SUBMISSIONS</a> | <a href="/journal/index.php/mji/indexing">ABSTRACTING &amp; INDEXING</a></p> <hr> <p>This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM).</p> <p>Abstracted and indexed in: <a title="EBSCO host" href="" target="_blank" rel="noopener">EBSCO host</a>, <a title="ACI" href=";id=9" target="_blank" rel="noopener">ASEAN Citation Index</a>, <a title="BASE" href="*;refid=dclink" target="_blank" rel="noopener">BASE</a>, <a title="CABI" href=";letter=M#SerialsCited" target="_blank" rel="noopener">CABI</a>, <a title="CiteFactor" href="" target="_blank" rel="noopener">CiteFactor</a>, <a title="CNKI" href=";rt=Journal" target="_blank" rel="noopener">CNKI</a>, <a title="Crossref" href=";publication=Medical+Journal+of+Indonesia" target="_blank" rel="noopener"> Crossref </a>, <a title="Dimensions" href="" target="blank">Dimensions</a>, <a title="DOAJ" href="{%22query%22:{%22query_string%22:{%22query%22:%22faculty%20of%20medicine%20universitas%20indonesia%22,%22default_field%22:%22index.publisher%22,%22default_operator%22:%22AND%22}}}" target="_blank" rel="noopener">DOAJ</a>, <a title="Electronic Journals Library" href=";colors=7&amp;lang=en&amp;jq_type1=KT&amp;jq_term1=medical+journal+of+indonesia" target="_blank" rel="noopener">Electronic Journals Library</a>, <a title="Embase" href="" target="_blank" rel="noopener">Embase</a>, <a title="ESCI" href=";Full=medical%20journal%20of%20indonesia" target="_blank" rel="noopener">ESCI</a>, <a title="GARUDA" href="" target="_self">GARUDA</a>, <a title="Google Scholar" href=";btnG=&amp;hl=en&amp;as_sdt=0%2C5" target="_blank" rel="noopener">Google Scholar</a>, <a title="Hinari" href="" target="_blank" rel="noopener">Hinari</a>, <a title="IMSEAR" href="" target="_blank" rel="noopener">IMSEAR</a>, <a title="ISC" href="" target="_blank" rel="noopener">ISC</a>, <a title="J-Gate" href="" target="_blank" rel="noopener"> J-Gate </a>, <a title="JournalTOCs" href=";subAction=pub&amp;publisherID=2793&amp;journalID=29425&amp;pageb=1&amp;userQueryID=&amp;sort=&amp;local_page=1&amp;sorType=&amp;sorCol=1" target="_blank" rel="noopener">JournalTOCs</a>, <a title="Microsoft Academic" href="" target="_blank" rel="noopener">Microsoft Academic</a>, <a title="MENDELEY" href="" target="_blank" rel="noopener"> MENDELEY </a>, <a title="PKP INDEX" href="">PKP index</a>, <a title="ProQuest" href=";productID=445&amp;productName=ProQuest+Health+%26+Medical+Complete&amp;IDString=445&amp;format=formatHTML&amp;issn=issn&amp;prflag=prflag&amp;cit=cit&amp;abs=abs&amp;pmid=pmid&amp;combined=combined" target="_blank" rel="noopener">Proquest</a>, <a title="ROAD" href="" target="_blank" rel="noopener"> ROAD </a>, <a title="Scilit" href="" target="_blank" rel="noopener">Scilit</a>, <a title="Scopus" href="" target="_blank" rel="noopener">Scopus</a>, <a title="SINTA" href="" target="_blank" rel="noopener">SINTA</a>, <a title="Ulrichsweb Global Serial Directory" href="" target="_blank" rel="noopener">Ulrichsweb Global Serial Directory</a>, <a title="WorldCat" href=";fq=&amp;dblist=239&amp;se=%24d&amp;sd=desc&amp;fc=yr:_25&amp;qt=show_more_yr%3A&amp;cookie" target="_blank" rel="noopener">WorldCat</a>.</p> <p>Accredited (2016-2020) by the Directorate General of Research and Development Strengthening of the Ministry of Research, Technology and Higher Education of the Republic of Indonesia (No:21/E/KPT/2018).</p> Editor's note 2023-12-22T16:29:08+07:00 Hans Joachim Freisleben 2023-09-06T00:00:00+07:00 Copyright (c) 2023 Hans Joachim Freisleben Development of kidney transplantation as a healthcare development model to achieve Indonesia Emas 2045 2023-12-22T16:29:08+07:00 Nur Rasyid Endang Susalit Arry Rodjani 2023-11-13T00:00:00+07:00 Copyright (c) 2023 Nur Rasyid, Endang Susalit, Arry Rodjani Effects of methotrexate, <em>Moringa oleifera</em>, and <em>Andrographis paniculata</em> extracts on the myocardial and aortic tissue of streptozotocin-nicotinamide-induced hyperglycemic rats 2023-12-25T09:45:36+07:00 Dimas Bathoro Bagus Pamungkas Viskasari Pintoko Kalanjati Abdurachman Dwi Martha Nur Aditya Muhammad Husni Fansury Nasution Maya Rahmayanti Syamhadi <p><strong>BACKGROUND</strong> Methotrexate (MTX) could lower glucose levels in type 1 diabetes mellitus, while Moringa oleifera and Andrographis paniculata supplementations have similar effects on hyperglycemia. This study aimed to analyze the effects of MTX, <em>M. oleifera</em>, and <em>A. paniculata</em> leaf extracts on the myocardial interleukin (IL)-6 and the histopathology of the left ventricle and aorta.</p> <p><strong>METHODS</strong> 49 rats were divided equally into 7 groups: negative control and diabetic induced by streptozotocin-nicotinamide (STZ-NA) injection consisting of positive control (STZ-NA only), <em>M. oleifera</em> (500 mg/kgBW/day), <em>A. paniculata</em> (500 mg/kgBW/day), MTX (7 mg/kgBW/week), MTX (7 mg/kgBW/week)+<em>M. oleifera</em> (500 mg/kgBW/day), and MTX (7 mg/kgBW/week)+<em>A. paniculata</em> (500 mg/kgBW/day). We analyzed oral MTX, <em>M. oleifera</em>, and <em>A. paniculata</em> leaf extracts’ effects on random blood glucose, myocardial IL-6, and cardiac histopathology of STZ-NA-induced hyperglycemic male rats. Data were analyzed using Wilcoxon and Kruskal–Wallis tests.</p> <p><strong>RESULTS</strong> Myocardial IL-6 in the <em>M. oleifera</em> group was significantly lower compared to the positive control group (<em>p</em> = 0.041). Compared to the positive control group, the myocardial necrosis and aortic intima–media thickness in the MTX+<em>A. paniculata</em> group were significantly reduced (<em>p</em> = 0.005 and 0.001, respectively).</p> <p><strong>CONCLUSIONS</strong> MTX, <em>M. oleifera</em>, and <em>A. paniculata</em> showed antihyperglycemic effect, both individually and in combination. <em>A. paniculata</em> leaf extract had a significant cardioprotective effect in STZ-NA-induced hyperglycemia.</p> 2023-12-22T00:00:00+07:00 Copyright (c) 2023 Dimas Bathoro Bagus Pamungkas, Viskasari Pintoko Kalanjati, Abdurachman, Dwi Martha Nur Aditya, Muhammad Husni Fansury Nasution, Maya Rahmayanti Syamhadi Effect of <em>arum manis</em> mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats 2023-12-23T09:45:26+07:00 Taufik Saputra Haidar Satya Naufal Astika Widy Utomo Nyoman Suci Widyastiti Muhammad Farhan Kurniawan Arfianty Nur Azizah <p><strong>BACKGROUND</strong> Dyslipidemia is characterized by an increase in low-density lipoprotein (LDL) and triglyceride (TG) levels and a decrease in high-density lipoprotein (HDL). Cholestyramine as an antidyslipidemia has several side effects, so an alternative is needed. Pectin is a natural substance with a mechanism of action similar to that of cholestyramine. Mango peel is one of the sources of pectin, containing 10–15% of this substance. This study aimed to prove the effect of <em>arum manis mango</em> (<em>Mangifera indica L.</em>) peel extract on LDL, HDL, and TG levels in dyslipidemic Sprague-Dawley rats.</p> <p><strong>METHODS</strong> 25 Sprague-Dawley rats were divided into 5 groups. All groups were given high-fat diet for the first 18 days, followed by standard feed (negative control group), cholestyramine (Sequest®) 80 mg/200 g body weight (standard treatment group), and mango peel extract (M-90 [90 mg/day], M-180 [180 mg/day], and M-360 [360 mg/day] groups) for the next 15 days. LDL and HDL levels were analyzed using the cholesterol oxidase-phenyl aminopyrazolone method and TG level using the glycerol-3-phosphate-oxidase-phenol-aminophenazone method.</p> <p><strong>RESULTS</strong> The M-360 group reduced the LDL level (<em>p</em> = 0.015), while the standard treatment group increased the HDL level (<em>p</em> = 0.042). Although significant TG level changes were found in the negative control, standard treatment, and M-360 groups (<em>p</em> = 0.042), the mean differences of LDL, HDL, and TG levels between groups were not significantly different (<em>p</em> = 0.245, 0.328, and 0.454, respectively).</p> <p><strong>CONCLUSIONS</strong> <em>M. indica</em> peel extract reduced LDL and TG levels at 360 mg/day.</p> 2023-12-22T16:02:04+07:00 Copyright (c) 2023 Taufik Saputra, Haidar Satya Naufal, Astika Widy Utomo, Nyoman Suci Widyastiti, Muhammad Farhan Kurniawan, Arfianty Nur Azizah Bambara groundnut ameliorates kidney histology in female mice with protein deficiency 2023-12-22T16:29:11+07:00 Vykra Aulia Firdiana Rimonta Febby Gunanegara Sunarti Ardaning Nuriliani <p><strong>BACKGROUND</strong> Protein deficiency (PD) can lead to kidney damage. Consuming plant-based proteins may improve this condition. Bambara groundnut (Vigna subterranea)has an essential amino acid score of 80%, which is higher than other legumes; thus, it is potent in overcoming malnutrition. This study aimed to determine the effect of Bambara groundnut supplementation on kidney histology in adult female mice with PD.</p> <p><strong>METHODS</strong> The study was conducted for 2 months in randomly selected female mice. These mice were grouped into the control, PD, and PD supplemented with Bambara groundnuts at 100, 200, and 300 g/kg of feed. 1 day after the last treatment, the kidneys of the mice were collected and processed histologically using the paraffin method (stained with hematoxylin and eosin and Masson’s trichrome). Parameters for observation included histopathological scoring (glomerular and interstitial space fibrosis and tubular damage), kidney histomorphometry, and organ index. Semi-quantitative data were analyzed using the Kruskal–Wallis test, while quantitative data were analyzed using one-way ANOVA (followed by Tukey’s test) and nested <em>t</em>-test. Statistical analysis was performed using SPSS software version 20 (IBM Corp., USA) (<em>p</em>≤0.05).</p> <p><strong>RESULTS</strong> PD caused cell sloughing (moderate level) and dilatation (severe level) of the kidney tubules. It also reduced glomerular diameter and area by approximately 17.66% and 29%, respectively. PD and Bambara groundnut administration had no significant effects on the glomerular number, cortex and medulla thickness, distal and proximal tubule diameter, and kidney organ index (<em>p</em>&gt;0.05).</p> <p><strong>CONCLUSIONS</strong> Bambara groundnut (<em>V. subterranea</em>) administration prevented damage to the kidney’s histological structure of protein-deficient mice.</p> 2023-12-11T00:00:00+07:00 Copyright (c) 2023 Vykra Aulia Firdiana, Rimonta Febby Gunanegara, Sunarti, Ardaning Nuriliani Validity and reliability of the Indonesian version of the 9-item Inflammatory Bowel Disease Questionnaire (IBDQ-9) 2024-01-02T11:01:41+07:00 Dekta Filantropi Esa Hamzah Shatri Cleopas Martin Rumende Adityo Susilo Hasan Maulahela Achmad Fauzi Marcellus Simadibrata <p><strong>BACKGROUND</strong> Decreasing the quality of life (QoL) of patients with inflammatory bowel disease (IBD) will increase morbidity and mortality. A valid and reliable instrument is needed to assess the QoL of patients with IBD. This study aimed to analyze the validity and reliability of the Indonesian version of the 9-item Inflammatory Bowel Disease Questionnaire (IBDQ-9).</p> <p><strong>METHODS</strong> This cross-sectional study was conducted using the Indonesian version of the IBDQ-9 in adult patients with IBD at the Gastroenterology Outpatient Clinic, Cipto Mangunkusumo Hospital, Jakarta, in November 2022. Patients aged 18 to 59 years who had experienced IBD for at least 2 weeks and provided informed consents were included. The total score of the IBDQ-9 Indonesian version was compared with the 36-item Short-Form Health Survey (SF-36) using the Spearman's correlation test. Reliability tests were examined using Cronbach’s alpha and the intraclass correlation coefficient (ICC).</p> <p><strong>RESULTS</strong> A total of 124 participants were included in this study. The Spearman's test showed a high and significant result for the IBDQ-9 Indonesian version and the SF-36 (r = 0.769 and <em>p</em>&lt;0.001). Cronbach’s alpha and ICC coefficient were equal to 0.883.</p> <p><strong>CONCLUSIONS</strong> This study provided evidence of the good validity and reliability of the IBDQ-9 Indonesian version for assessing the QoL of patients with IBD in Indonesia.</p> 2023-12-22T16:06:26+07:00 Copyright (c) 2023 Dekta Filantropi Esa, Hamzah Shatri, Cleopas Martin Rumende, Adityo Susilo, Hasan Maulahela, Achmad Fauzi, Marcellus Simadibrata Lateral facial profile of β-thalassemia major in Javanese children: a photogrammetric analysis 2023-12-23T09:45:24+07:00 Wulan Geraldine Parengkuan Sri Kuswandari Indah Titien Soeprihati <p><strong>BACKGROUND</strong> Impairment of globin chain synthesis in patients with β-thalassemia major causes ineffective erythropoiesis. This condition triggers bone marrow hyperplasia and can lead to craniofacial bone abnormalities. This study aimed to evaluate the lateral facial profile of β-thalassemia major, identify any differences when compared with a control group of similar age and ethnicity, and reveal the facial profile of β-thalassemia major in Javanese children.</p> <p><strong>METHODS</strong> This cross-sectional study included 35 β-thalassemia major children aged 7–15 years. They were divided into 3 groups based on their age. Lateral facial photogrammetry was taken by measuring the forehead protrusion and nasolabial angle. Data were then mapped to the normal group of children in the same age group and descriptively analyzed using SPSS software.</p> <p><strong>RESULTS</strong> The 1 and 2 SD group had a higher prevalence of β-thalassemia major in children aged 7–9 years for both sexes. The older age group had a closer mean value to those of children without thalassemia.</p> <p><strong>CONCLUSIONS</strong> The forehead and maxillary profile of Javanese β-thalassemia major children tended to be protrusive, especially in the 7–9 years age group, while the older age groups had closer mean values to those of children without thalassemia.</p> 2023-12-22T16:08:39+07:00 Copyright (c) 2023 Wulan Geraldine Parengkuan, Sri Kuswandari, Indah Titien Soeprihati Vitamin D levels and depression in type 2 diabetes mellitus patients: a cross-sectional study 2023-12-22T16:29:15+07:00 Rudi Putranto Kresna Adhiatma Tri Juli Edi Tarigan Cleopas Martin Rumende Hamzah Shatri Iris Rengganis Pringgodigdo Nugroho Ikhwan Rinaldi <p><strong>BACKGROUND</strong> The prevalence of type 2 diabetes mellitus (T2DM) is increasing and commonly accompanied by comorbidities, such as depression. Vitamin D levels have been associated with T2DM and depression although the mechanism is uncertain. This study aimed to compare vitamin D levels between patients with T2DM with and without depression in the Indonesian community, where such research is rare.</p> <p><strong>METHODS</strong> This cross-sectional study was conducted at Cipto Mangunkusumo Hospital. The participants who met the inclusion criteria on an outpatient basis were screened for depression using the Beck Depression Inventory-II (BDI-II) questionnaire and then divided into 2 groups: patients with T2DM with (BDI-II ≥14) and without (BDI-II &lt;14) depression. Both groups were examined for vitamin D levels using the ELISA method, and an analysis of the mean difference between both groups was performed.</p> <p><strong>RESULTS</strong> Of 60 patients, 23 (38%) experienced depression. The median vitamin D levels were 21.8 ng/ml (IQR 14.9–26.6) in the depression group and 26.5 ng/ml (IQR 23.96–34.08) in the non-depression group (<em>p</em> = 0.001). After performing multivariate analysis with confounding variables, the adjusted OR of variables (sex, sun exposure score, and body mass index) was 1.123 (95% CI: 1.003–1.259; <em>p</em> = 0.045).</p> <p><strong>CONCLUSIONS</strong> Vitamin D levels were significantly lower in patients with T2DM with depression. Future studies should be carried out to determine the benefits of vitamin D supplementation in patients with T2DM with depression and their pathophysiology.</p> 2023-12-14T00:00:00+07:00 Copyright (c) 2023 Rudi Putranto, Kresna Adhiatma, Tri Juli Edi Tarigan, Cleopas Martin Rumende, Hamzah Shatri, Iris Rengganis, Pringgodigdo Nugroho, Ikhwan Rinaldi Characteristics of pressure injuries among geriatric patients at an Indonesian tertiary hospital: a cross-sectional study 2023-12-22T16:29:16+07:00 Shannaz Nadia Yusharyahya Lili Legiawati Rinadewi Astriningrum Reganedgary Jonlean Vega Andhira <p><strong>BACKGROUND</strong> Pressure injury develops due to sustained pressure at the bony prominence of the skin and tissues. Geriatric patients often have multiple comorbidities, predisposing them to pressure injury. Data on the characteristics of the geriatric with pressure injuries are still limited. This study aimed to report the characteristics of geriatric patients with pressure injuries admitted at a tertiary hospital in Indonesia.</p> <p><strong>METHODS</strong> This cross-sectional study used medical records of geriatric patients admitted with all stages of pressure injuries consulted to the Department of Dermatology and Venereology at a tertiary hospital in Indonesia between January 2017 and April 2021. Pressure injuries were classified based on the 2019 National Pressure Injury Advisory Panel guideline.</p> <p><strong>RESULTS</strong> 39 patients presented with varied pressure injury characteristics. The sacral region was the most reported site (36%), with stage 2 pressure injury being the most commonly found stage in the patients (74%). Interestingly, 22% of the patients had pressure injuries found on the atypical sites due to prolonged surgery or the pressure of medical devices. More than half of the patients used conventional dressings (51.3%). Immobility was found in 35.9% of the patients due to being bedridden.</p> <p><strong>CONCLUSIONS</strong> No characteristics were found as a significant risk factor for pressure injury formation during or outside the admission period. However, a history of surgery might be related to pressure injury formation during admission.</p> 2023-11-14T00:00:00+07:00 Copyright (c) 2023 Shannaz Nadia Yusharyahya, Lili Legiawati, Rinadewi Astriningrum, Reganedgary Jonlean, Vega Andhira Atypical orbital primary optic nerve sheath meningioma with severe disfiguring proptosis: an alternative surgical approach 2023-12-22T16:29:17+07:00 Sylves Patrick Yeap Boon Tat Muhamad Zarif Mohd Amin Maftuhim Addenan Shuaibah Ab.Ghani Hanida Hanafi <p>Primary optic nerve sheath meningioma is generally a benign tumor. In rare instances, however, the growth rate and intraocular and intracranial extensions can be highly aggressive, especially in children, leading to poor prognosis. Here, we reported a case of a 24-year-old woman who presented with left eye swelling for 3 years. This was associated with blurred vision, retrobulbar pain, and redness. On examination, the left eye was severely proptosed with complete ophthalmoplegia. Magnetic resonance imaging showed an extensive tumor occupying the whole left orbital cavity with a disfigured eyeball. However, no intracranial extension was observed. Interestingly, complete surgical excision was feasible via transconjunctival anterior orbitotomy without bone removal. The histopathological examination confirmed the diagnosis of optic nerve sheath meningioma. Adjunct radiotherapy was given. On a follow-up after 2 years, left enophthalmos with esotropia was observed.</p> 2023-11-01T00:00:00+07:00 Copyright (c) 2023 Sylves Patrick, Yeap Boon Tat, Muhamad Zarif Mohd Amin, Maftuhim Addenan, Shuaibah Ab.Ghani, Hanida Hanafi Transventricular transforaminal endoscopic fenestration with cysto-ventriculoperitoneal shunt to manage a third ventricular arachnoid cyst: a case report 2023-12-22T16:29:18+07:00 Nia Yuliatri Ingrid Ayke Widjaya Alphadenti Harlyjoy Gibran Aditiara Wibawa Satyanegara <p>Regular ventriculoperitoneal (VP) shunt is commonly used as the first option to manage a third ventricular arachnoid cyst due to the lack of facilities, unfamiliarity with endoscopic techniques, or misdiagnosis as purely obstructive hydrocephalus. A 9-year-old girl with obstructive hydrocephalus due to a third ventricular arachnoid cyst was treated with a VP shunt. 2 months later, the previous shunt device was removed due to an infection. Following a sterile cerebrospinal fluid analysis culture, we conducted a navigation-assisted transventricular transforaminal endoscopic fenestration and cysto-VP programmable shunt placement. A decrease in ventricular dilatation was seen on follow-up. This approach was justified due to the possibility of establishing communication with normal cisterns, the high rate of cyst elimination, and the potential for achieving shunt independence. Performing an endoscopic fenestration followed by cysto-VP shunt placement could be an optimal option for managing this condition.</p> 2023-10-17T00:00:00+07:00 Copyright (c) 2023 Nia Yuliatri, Ingrid Ayke Widjaya, Alphadenti Harlyjoy, Gibran Aditiara Wibawa, Satyanegara Corrigendum: Quadrigeminal plate arachnoid cyst presenting with eye movement related migraine: a rare case report 2023-12-23T09:45:21+07:00 Yemima Graciela Robert Shen Mardjono Tjahjadi <p>[This corrects the article DOI: 10.13181/]</p> 2023-12-22T16:15:12+07:00 Copyright (c) 2023 Yemima Graciela, Robert Shen, Mardjono Tjahjadi Front & Back Matter 2023-12-23T09:45:29+07:00 Medical Journal of Indonesia 2023-12-22T00:00:00+07:00 Copyright (c)