https://mji.ui.ac.id/journal/index.php/mji/issue/feed Medical Journal of Indonesia 2023-04-19T09:23:50+07:00 Med J Indones mji@ui.ac.id Open Journal Systems <p><a href="http://mji.ui.ac.id/journal/index.php/mji/aboutbrief">ABOUT JOURNAL</a> | <a href="http://scholar.google.com/citations?user=4rXbpKoAAAAJ&amp;hl=en" target="_blank&quot;">CITATIONS</a> | <a href="https://mji.ui.ac.id/journal/index.php/mji/stat">STATISTIC</a> | <a href="/journal/index.php/mji/submit">SUBMISSIONS</a> | <a href="/journal/index.php/mji/indexing">ABSTRACTING &amp; INDEXING</a></p> <hr> <p>This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM).</p> <p>Abstracted and indexed in: <a title="EBSCO host" href="https://www.ebscohost.com/titleLists/a9h-journals.htm" target="_blank" rel="noopener">EBSCO host</a>, <a title="ACI" 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Education of the Republic of Indonesia (No:21/E/KPT/2018).</p> https://mji.ui.ac.id/journal/index.php/mji/article/view/6924 Short stature and stunting in Indonesia: problems and innovative alternative solutions 2023-04-19T09:23:49+07:00 Agus Rizal Ardy Hariandy Hamid rizalhamid.urology@gmail.com <p>[No abstract available]</p> 2023-04-17T12:10:09+07:00 Copyright (c) 2023 Agus Rizal Ardy Hariandy Hamid https://mji.ui.ac.id/journal/index.php/mji/article/view/6439 Association between interleukin-2 (rs2069762) gene polymorphism and FVIII inhibitor development in Indonesian patients with severe hemophilia A 2023-04-18T16:42:03+07:00 Sri Marwanta marwantasppdmkes@student.uns.ac.id Faizal Muhammad faizal9m@student.uns.ac.id Suradi Maryono suradimaryono.sm@gmail.com Kun Salimah kun.perdana@gmail.com Sihwidhi Dimas Sudarmadi sihwidhidimas@yahoo.com Bambang Purwanto bambangp.solo@yahoo.com Brian Wasita brianwasita@yahoo.com Tonang Dwi Ardyanto tonang.ardyanto@staff.uns.ac.id Soetrisno soetrisno_spogk@yahoo.com <p><strong><span id="page13R_mcid24" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*219.49px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(0.893143);" role="presentation">BACKGROUND</span></span></strong><span id="page13R_mcid25" class="markedContent"> <span dir="ltr" style="left: calc(var(--scale-factor)*274.32px); top: calc(var(--scale-factor)*219.49px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.02843);" role="presentation">Factor VIII (FVIII) inhibitors in hemophilia A (HA) patients render FVIII </span></span><span id="page13R_mcid26" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*231.59px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.03715);" role="presentation">replacement therapy ineffective. Although its development cause is unclear, it has </span></span><span id="page13R_mcid27" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*243.69px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.06557);" role="presentation">been classified into therapeutic and genetic-related etiologies. Single nucleotide </span></span><span id="page13R_mcid28" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*255.79px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.01965);" role="presentation">polymorphisms (SNPs) in several cytokine genes, including interleukin (IL)-2, could </span></span><span id="page13R_mcid29" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*267.89px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.06346);" role="presentation">increase the risk of FVIII inhibitor development. This study aimed to evaluate the </span></span><span id="page13R_mcid30" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*279.99px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.02929);" role="presentation">association between IL-2 (rs2069762) gene SNP and FVIII inhibitor development in </span></span><span id="page13R_mcid31" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*292.09px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(0.989609);" role="presentation">Indonesian patients with severe HA.</span></span></p> <p><strong><span id="page13R_mcid32" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*316.29px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(0.911301);" role="presentation">METHODS</span></span></strong><span id="page13R_mcid33" class="markedContent"> <span dir="ltr" style="left: calc(var(--scale-factor)*256.50px); top: calc(var(--scale-factor)*316.29px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(0.911957);" role="presentation">The IL-2 (rs2069762) gene SNP was examined in 119 HA patients. The presence </span></span><span id="page13R_mcid34" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*328.39px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(0.984605);" role="presentation">of FVIII inhibitors was quantified using an enzyme-linked immunosorbent assay, with a </span></span><span id="page13R_mcid35" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*340.49px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.03119);" role="presentation">titer of &lt;0.28 ng/ml considered negative. Patients were divided into two groups: 59 </span></span><span id="page13R_mcid36" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*352.59px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.0371);" role="presentation">with FVIII inhibitors (positive group) and 60 without inhibitors (negative group). The </span></span><span id="page13R_mcid37" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*364.69px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.01772);" role="presentation">genotype of the subjects was determined using peripheral blood mononuclear cells </span></span><span id="page13R_mcid38" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*376.79px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(0.986984);" role="presentation">and tetra-primer amplification refractory mutation system-polymerase chain reaction.</span></span></p> <p><strong><span id="page13R_mcid39" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*400.99px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(0.858403);" role="presentation">RESULTS</span></span></strong><span id="page13R_mcid40" class="markedContent"> <span dir="ltr" style="left: calc(var(--scale-factor)*251.89px); top: calc(var(--scale-factor)*400.99px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(0.972015);" role="presentation">There was no association between IL-2 (rs2069762) gene polymorphism and </span></span><span id="page13R_mcid41" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*413.09px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.00779);" role="presentation">FVIII inhibitor development on genotypes (</span></span><em><span id="page13R_mcid42" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*377.76px); top: calc(var(--scale-factor)*413.25px); font-size: calc(var(--scale-factor)*9.00px); font-family: monospace;" role="presentation">p</span></span></em><span id="page13R_mcid43" class="markedContent"> <span dir="ltr" style="left: calc(var(--scale-factor)*384.14px); top: calc(var(--scale-factor)*413.09px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(0.945613);" role="presentation">= 0.138) and allele frequencies<em> (</em></span></span><em><span id="page13R_mcid44" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*502.48px); top: calc(var(--scale-factor)*413.25px); font-size: calc(var(--scale-factor)*9.00px); font-family: monospace;" role="presentation">p</span></span></em><span id="page13R_mcid45" class="markedContent"> <span dir="ltr" style="left: calc(var(--scale-factor)*508.86px); top: calc(var(--scale-factor)*413.09px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(0.952991);" role="presentation">= 0.780).</span></span></p> <p><strong><span id="page13R_mcid46" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*437.29px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(0.882617);" role="presentation">CONCLUSIONS</span></span></strong><span id="page13R_mcid47" class="markedContent"> <span dir="ltr" style="left: calc(var(--scale-factor)*277.37px); top: calc(var(--scale-factor)*437.29px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.11145);" role="presentation">IL-2 (rs2069762) gene polymorphism is not a risk factor in the </span></span><span id="page13R_mcid48" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*449.39px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.03122);" role="presentation">development of FVIII inhibitors in Indonesian patients with severe HA. Thus, further </span></span><span id="page13R_mcid49" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*461.49px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.00646);" role="presentation">polymorphism studies in other cytokine genes are required to gain a comprehensive </span></span><span id="page13R_mcid50" class="markedContent"><span dir="ltr" style="left: calc(var(--scale-factor)*215.44px); top: calc(var(--scale-factor)*473.59px); font-size: calc(var(--scale-factor)*9.00px); font-family: sans-serif; transform: scaleX(1.01664);" role="presentation">understanding of the FVIII inhibitor development.</span></span></p> 2023-03-08T00:00:00+07:00 Copyright (c) 2023 Sri Marwanta, Faizal Muhammad, Suradi Maryono, Kun Salimah, Sihwidhi Dimas Sudarmadi, Bambang Purwanto, Brian Wasita, Tonang Dwi Ardyanto, Soetrisno https://mji.ui.ac.id/journal/index.php/mji/article/view/6544 Novel point mutation and intronic mutations of <em>RB1</em> gene in retinoblastoma patients in Indonesia 2023-04-18T16:41:51+07:00 Batari Todja Umar riri_zainal@yahoo.co.id Ulfah Rimayanti rimayantiu@gmail.com Halimah Pagarra halimah_pa@yahoo.com Budu budu062011@yahoo.com Nasrum Massi nasrumm2000@yahoo.com Habibah Setyawati Muhiddin muhiddinhabibah@yahoo.co.id <p><strong>BACKGROUND</strong> Retinoblastoma (RB) is an inherited disorder caused by the <em>RB1</em> gene mutation in retinal cells or germline mutation. Identifying the specific mutation is crucial for prognosis, inheritance risk assessment, and treatment planning. This study aimed to identify the germline mutation in the <em>RB1</em> gene in patients with RB and their parents from the eastern part of Indonesia.</p> <p><strong>METHODS</strong> This observational analytic study recruited patients with RB and their parents between 2016 and 2018 at Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia. The normal control subjects were children from the outpatient clinic at the Department of Ophthalmology, Universitas Hasanuddin Hospital. Ophthalmic examinations and peripheral blood tests were performed in RB patients, their parents, and control subjects. Genomic DNA was isolated from blood leukocytes and amplified using conventional PCR. Hotspot exons 8, 10, 14, 17, and 22 were screened for mutations using the Sanger method.</p> <p><strong>RESULTS</strong> There were 21 patients with RB (16 unilateral and 5 bilateral) and 14 normal subjects. Of the 184 variations detected in RB patients, 164 were also found in normal subjects. 19 intronic mutations in introns 10, 16, 17, and 21, and 1 novel missense mutation in exon 17 were identified. Parental testing revealed 8 substitutions in exon 17 and 5 intronic mutations in introns 16 and 17 of the parents. None of the variations in exons were passed to their children.</p> <p><strong>CONCLUSIONS</strong> This study found a novel missense mutation in exon 17 of the <em>RB1</em> gene.</p> 2023-03-29T00:00:00+07:00 Copyright (c) 2023 Batari Todja Umar, Ulfah Rimayanti, Halimah Pagarra, Budu, Nasrum Massi, Habibah Setyawati Muhiddin https://mji.ui.ac.id/journal/index.php/mji/article/view/6324 Interferon-gamma release assay and chest X-ray to classify intraocular tuberculosis among clinically undifferentiated uveitis 2023-04-18T16:42:06+07:00 Mei Riasanti meiriasanti@yahoo.com Ikhwanuliman Putera iwankings@gmail.com Priscilla Jessica priscillajessica94@gmail.com Muhammad Zakiy Waliyuddin mummadzaki513@gmail.com Faiz Alwan Tagar alwantagar@gmail.com Andini Karlina CH andinikarlinach@gmail.com Yulia Aziza yuliaziza@gmail.com Made Susiyanti madesusiyanti@yahoo.com Lukman Edwar lukmanedwar@yahoo.com Ratna Sitompul ratna_sitompul@yahoo.com Rina La Distia Nora rina.ladistia@ui.ac.id <p><strong>BACKGROUND</strong> Tuberculosis (TB) is a common cause of intraocular inflammation in Indonesia. As no accurate biomarker can confirm the diagnosis, ophthalmologists often rely on systemic findings, such as tuberculin skin test, interferon-gamma release assay (IGRA), and chest X-ray (CXR) for TB suspicion. This study aimed to evaluate IGRA and CXR in classifying intraocular TB among patients with a clinically undifferentiated cause of uveitis.</p> <p><strong>METHODS</strong> This cross-sectional study included 116 patients (a total of 163 affected eyes) with a clinically undifferentiated cause of uveitis. IGRA and CXR were performed as part of the workup. Data on visual acuity, anterior chamber inflammation grade, and anatomical classification of uveitis were recorded. As there were no confirmed ocular tuberculosis (OTB) in our cases, eyes were classified into probable OTB, possible OTB, and unclassified.</p> <p><strong>RESULTS</strong> Overall, 93 patients (80.2%) with a clinically undifferentiated cause of uveitis had positive IGRA, whereas 10 (8.6%) had CXR results suggestive of TB. More than one-third of the patients were blind (visual acuity &lt;3/60), and panuveitis was the commonest anatomical classification. A trend was identified in patients with panuveitis, who often showed ≥2+ cell anterior chamber inflammation (<em>p</em> for trend = 0.023), according to OTB criteria (probable OTB = 3/4, 75.0%; possible OTB = 44/67, 65.7%; unclassified = 2/9, 22.2%). Furthermore, the clinically undifferentiated uveitis cases were eligible to be stratified into probable (8.6%) and possible (75.0%) OTB categories after IGRA and CXR examinations.</p> <p><strong>CONCLUSIONS</strong> The combination of IGRA and CXR is valuable for classifying and diagnosing TB-related uveitis. A multidisciplinary approach is essential when the cause of uveitis is unknown.</p> 2023-01-11T00:00:00+07:00 Copyright (c) 2023 Mei Riasanti, Ikhwanuliman Putera, Priscilla Jessica, Muhammad Zakiy Waliyuddin, Faiz Alwan Tagar, Andini Karlina CH, Yulia Aziza, Made Susiyanti, Lukman Edwar, Ratna Sitompul, Rina La Distia Nora https://mji.ui.ac.id/journal/index.php/mji/article/view/6244 Safety of a 2-dose primary series of 13-valent pneumococcal conjugate vaccine in Indonesian infants 2023-04-18T16:41:57+07:00 Julitasari Sundoro drjulitasaripmspcv13@gmail.com Ari Prayitno ariprayitno@yahoo.com Hindra Irawan Satari hsatari@ikafkui.net I Gusti Gede Djelantik iggdjelantik@gmail.com Mark Andrew Fletcher mark.a.fletcher@pfizer.com Sri Rezeki Hadinegoro shadinegoro46@gmail.com Syafriyal syafriyal@gmail.com <p><strong>BACKGROUND</strong> In 2017, the Indonesian Technical Advisory Group on Immunization recommended a safety monitoring demonstration program for the 13-valent pneumococcal conjugate vaccine (PCV13) in West Lombok and East Lombok, West Nusa Tenggara to evaluate the 2-dose primary series (2 and 3 months of age) for serious adverse events (SAEs), adverse events, systemic events, and local reactions.</p> <p><strong>METHODS</strong> A total of 1,083 infants from 10 primary healthcare centers were analyzed, with 687 receiving the first dose and 396 receiving the second dose. Based on the national immunization program, they received PCV13 + DTwP-HB-Hib + OPV (n = 544), PCV13 + DTwP-HB-Hib (n = 101), or PCV13 only (n = 403). They were monitored for 30 min after vaccination for any immediate SAEs, and parents were given a diary card to record safety information prospectively for 28 days.</p> <p><strong>RESULTS</strong> No immediate SAEs were observed, and no SAEs were reported during 28 days after vaccination. Reports of local reactions and systemic events predominated on days 1–3 post-vaccination. Severe fever (axillary temperature &gt;39.0°C) was uncommon (&lt;2% of all infants). Most irritability was mild to moderate. Local pain was more frequent after the first dose than after the second dose. It was distributed evenly across mild, moderate, and severe classifications, while redness and swelling were mostly mild to moderate.</p> <p><strong>CONCLUSIONS</strong> The PCV13 primary series demonstration program in Indonesia confirmed tolerable local and systemic reactions.</p> 2023-03-24T00:00:00+07:00 Copyright (c) 2023 Julitasari Sundoro, Ari Prayitno, Hindra Irawan Satari, I Gusti Gede Djelantik, Mark Andrew Fletcher, Sri Rezeki Hadinegoro, Syafriyal https://mji.ui.ac.id/journal/index.php/mji/article/view/6382 Risk factors of limited joint mobility in type 1 diabetic adolescents: a two-center experience in Iraq 2023-04-18T16:42:01+07:00 Wasnaa Hadi Abdullah wasnaa.hadi@uomustansiriyah.edu.iq Rihab Faisal Alabedi faisal.rehab@gmail.com Russul Feihan Mussa russulfeihan@uobabylon.eud.iq <p><strong>BACKGROUND</strong> Limited joint mobility (LJM) is the most common joint-related complications in patients with diabetes mellitus (DM) and indicates the presence of microvascular complications. This study aimed to assess the frequency of LJM among adolescents with type 1 DM (T1DM), its risk factors, and the other microangiopathies.</p> <p><strong>METHODS</strong> In this cross-sectional study, 75 patients (adolescents between 10 and 17 years old) with T1DM were assessed for hand joint mobility using a prayer sign test. It was carried out from January 15 to June 1, 2022 in Baghdad city, Iraq. The patients’ height, body mass index, blood pressure, glycated hemoglobin, and low-density lipoprotein (LDL) were recorded. Only 44 subjects were screened for diabetic nephropathy and 64 for diabetic retinopathy based on the eligibility criteria by the American Diabetes Association guidelines.</p> <p><strong>RESULTS</strong> Mean age was 13.60 (1.85) years, with a mean diabetes duration of 5.61 (2.87) years. LJM was found in 18 patients (24%). It was associated with a longer duration of diabetes (<em>p</em>&lt;0.001), high LDL level (<em>p</em> = 0.012), diabetic nephropathy (<em>p</em> = 0.04), and diabetic retinopathy (<em>p</em>&lt;0.001).</p> <p>CONCLUSIONS The proportion of LJM was high among adolescents with T1DM, especially in those with a long duration of DM. It was associated with high LDL levels and diabetic microangiopathies (nephropathy and retinopathy).</p> 2023-03-20T00:00:00+07:00 Copyright (c) 2023 Wasnaa Hadi Abdullah, Rihab Faisal Alabedi, Russul Feihan Mussa https://mji.ui.ac.id/journal/index.php/mji/article/view/6375 Evaluation of anal cytology and human papillomavirus infection in high-risk women: a cross-sectional study 2023-04-18T16:41:49+07:00 Tahereh Ashrafganjoei dr_tganjoei@sbmu.ac.ir Maryam Sadat Hosseini maryamhosseini39@sbmu.ac.ir Zanbagh Pirastehfar drpirastehfarzanbagh@sbmu.ac.ir Farah Farzaneh f_farzaneh@sbmu.ac.ir Maliheh Arab drmarab@yahoo.com Noushin Ashfar Moghaddam afsharmoghadam@sbmu.ac.ir Abdolreza Javadi reza.javadi@sbmu.ac.ir Ali Yaghobi Joybari dryaghobi@sbmu.ac.ir <p><strong>BACKGROUND</strong> Anal cancer incidence has been on the rise over the past few decades. This study aimed to assess anal Papanicolaou (Pap) smear changes in women with high risk for dysplasia and human papillomavirus (HPV) infection.</p> <p><strong>METHODS</strong> This cross-sectional study was conducted on 121 patients referred to the Gynecology Oncology Clinic of Imam Hossein Medical Center between 2020 and 2021 in Tehran, Iran, who had cervical and vulvar dysplasia, cervical HPV infection, and abnormal cervical cytology results and were over 21 years old. Data analysis was performed using SPSS software version 21 (IBM Corp., USA) at a significance level of 0.05.</p> <p><strong>RESULTS</strong> 121 women, with a mean age of 39.69 years, were included in this study. Overall, 23.1% of women had positive anal HPV results, and 35.5% were over 40 years old. Younger age was associated with an increased risk of anal HPV (<em>p</em> = 0.045). 33.9% of women were single and had a higher risk of anal HPV. Multiple sexual partnerships and anal sex were the significant risk factors for anal cancer (<em>p</em>&lt;0.001). Women with positive anal HPV results had significantly more genital warts (<em>p</em>&lt;0.001). No significant difference was observed in smoking, educational level, and cervical Pap smear results between women with negative and positive rectal HPV results.</p> <p><strong>CONCLUSIONS</strong> Younger age at diagnosis, being single, having multiple sexual partnerships, having anal sex, and having genital warts were associated with anal HPV infection in women. Abnormal anal cytology was only associated with being single and having multiple sexual partners.</p> 2023-03-30T00:00:00+07:00 Copyright (c) 2023 Tahereh Ashrafganjoei , Maryam Sadat Hosseini, Zanbagh Pirastehfar, Farah Farzaneh , Maliheh Arab , Noushin Ashfar Moghaddam , Abdolreza Javadi, Ali Yaghobi Joybari https://mji.ui.ac.id/journal/index.php/mji/article/view/6347 Surgical techniques to reduce oronasal fistula risk in wide cleft palate repair: a systematic review 2023-04-19T09:23:50+07:00 Prasetyanugraheni Kreshanti prasetyanugraheni@ui.ac.id Patricia Marcellina Sadikin patricia_marcellina@yahoo.com Margareth Ingrid Anggraeni anggraeniingrid@gmail.com Jasmine Athiyya Wibowo jasmineathiyya96@agmail.com Kristaninta Bangun kristaninta@gmail.com <p><strong>BACKGROUND</strong> Wide cleft palate is a common congenital anomaly, particularly in developing countries with limited access to plastic surgeons and specialized cleft centers. It can be severe and may contribute to the development of oronasal fistula, which can occur in up to 78% of cases. Despite numerous surgical techniques for wide cleft repair, the best method remains unclear. This study aimed to identify surgical techniques for wide cleft palate repair to minimize the occurrence of oronasal fistula.</p> <p><strong>METHODS</strong> Literature searching was conducted using multiple online databases including PubMed, Scopus, and Cochrane Library. The keywords used were “cleft palate”, ” surgery”, “technique”, “palatoplasty”, and “wide”. Inclusion and exclusion criteria were applied to select relevant studies, and the quality was assessed.</p> <p><strong>RESULTS</strong> A total of 12 studies discussed surgical techniques to repair the primary wide cleft palate and their outcome on oronasal fistula formation. The surgical techniques included modified Furlow palatoplasty, two-flap palatoplasty, and modified Bardach’s two-flap palatoplasty. The incidence of oronasal fistula was 9.6% (n = 28/291) in one-stage Furlow palatoplasty and 12.0% (n = 24/200) in the modified one-stage two-flap palatoplasty.</p> <p><strong>CONCLUSIONS</strong> Two-flap palatoplasty and Furlow palatoplasty (and their modifications) were the safe surgical techniques for wide cleft repair with a low occurrence of oronasal fistula.</p> 2023-04-17T12:08:24+07:00 Copyright (c) 2023 Prasetyanugraheni Kreshanti, Patricia Marcellina Sadikin, Margareth Ingrid Anggraeni, Jasmine Athiyya Wibowo, Kristaninta Bangun https://mji.ui.ac.id/journal/index.php/mji/article/view/6337 Subgingival chlorhexidine irrigation for scaling and root planing adjunctive therapy in chronic periodontitis: a systematic review 2023-04-18T16:41:52+07:00 Agus Susanto agus.susanto@fkg.unpad.ac.id Nunung Rusminah nunung.rusminah@fkg.unpad.ac.id Yohana Putri Pertiwi yohana18003@mail.unpad.ac.id <p><strong>BACKGROUND</strong> Scaling and root planing (SRP) is a conventional treatment for chronic periodontitis; however, it has limitations in treating deep pockets. To enhance its efficacy, chlorhexidine (CHX) is proposed as adjunctive therapy with SRP due to its broad antimicrobial spectrum, low systemic toxic activity in humans, absence of oral microorganism resistance, and lack of teratogenic effects. This study aimed to know the efficacy of the adjunctive therapy of CHX.</p> <p><strong>METHODS</strong> A literature search was conducted using various databases including PubMed, LIVIVO, EBSCOhost, and Google Scholar, following the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines within the last 10 years (2011–2021). Clinical parameters such as plaque index (PI), gingival index (GI), bleeding on probing (BOP), pocket depth (PD), and clinical attachment level (CAL) were recorded. The risk of bias in the selected studies was assessed using Cochrane Collaboration’s Handbook version 5.2.0.</p> <p><strong>RESULTS</strong> Of 368 studies, 10 met the inclusion criteria, with 8 of them having a higher quality. Higher reduction of PI, GI, BI, PD, and CAL were observed in SRP with CHX irrigation compared with SRP alone.</p> <p><strong>CONCLUSIONS</strong> Overall, adding CHX to SRP appeared to have additional clinical benefits compared with SRP alone in the treatment of chronic periodontitis.</p> 2023-03-24T00:00:00+07:00 Copyright (c) 2023 Agus Susanto, Nunung Rusminah, Yohana Putri Pertiwi https://mji.ui.ac.id/journal/index.php/mji/article/view/6388 Multiple vaginal stones secondary to an ectopic ureter in an adult female patient: a case report 2023-04-18T16:42:02+07:00 Muhammad Adi Satrio Lazuardi adisatrio83@gmail.com Andrie Rhomdhon Kurniawan andrie.rhomdhon@yahoo.com Pradana Nurhadi dan_firas@yahoo.com Besut Daryanto urobes.fk@ub.ac.id <p>Vaginal stone is a rare case with low incidence. Ectopic ureter insertion into the vagina is one of the congenital abnormalities that may lead to vaginal stone formation. True incontinence persisting until adulthood might indicate an ectopic ureter, often associated with a complete duplex renal system. We reported an adult female that came with a chief complaint of true incontinence since she was young. However, it was left untreated due to limited healthcare facilities in her area and low socioeconomic status. The computed tomography examination revealed a right complete duplex renal system, with upper moiety inserted into the vagina, and multiple vaginal stones. Thus, stone removal and ureteroneocystostomy procedure were performed. No further complaints or complications were recorded after the hospital discharge.</p> 2023-03-10T00:00:00+07:00 Copyright (c) 2023 Muhammad Adi Satrio Lazuardi, Andrie Rhomdhon Kurniawan, Pradana Nurhadi, Besut Daryanto https://mji.ui.ac.id/journal/index.php/mji/article/view/6351 Pancreatoblastoma in previously pancreatic pseudocysts in a 14-year-old female: a case report 2023-04-18T16:42:05+07:00 Monica Bellynda bellyndamonica@gmail.com Marsih marsihmitro07@gmail.com Yohanes Adinugroho yohanestn18@gmail.com Suwardi suwardi_drspba@yahoo.com Muhammad Riza m_riza@staff.uns.ac.id Faizal Muhammad faizal9m@student.uns.ac.id <p>Pancreatoblastoma is a rare tumor characterized by uncontrolled growth of pancreatic epithelial cells with a mix of squamous nests and acinar differentiation. Diagnostic modalities include abnormal liver enzyme, pancreatic enzyme, and imaging findings. Treatment options include surgical resection, sometimes combined with chemotherapy, depending on the tumor’s size and grade. We reported a pancreatoblastoma in a 14-year-old female with prior pancreatic pseudocysts. The transformation from pseudocysts to pancreatoblastoma is believed to be caused by the heterozygosity molecular loss on the 11p chromosome and several genetic mutations. Magnetic resonance cholangiopancreatography showed a well-defined, heterogeneous mass in the pancreatic head, with 70% of the mass composed of cysts. A partial pancreatectomy was performed because a complete pancreatectomy may harm the adjacent structures. However, a complete resection combined with chemoradiation may be the best option for long-term survival and complete remission. In this case, she was disease-free until 30 months after the chemotherapy protocol.</p> 2023-02-27T00:00:00+07:00 Copyright (c) 2023 Monica Bellynda, Marsih, Yohanes Adinugroho, Suwardi, Muhammad Riza, Faizal Muhammad https://mji.ui.ac.id/journal/index.php/mji/article/view/6928 Corrigendum: Comparison of ultrasonography and fluoroscopy as guides for extracorporeal shock wave lithotripsy in nephrolithiasis patients: a systematic review 2023-04-19T09:23:49+07:00 Gede Wirya Kusuma Duarsa gwkurology@gmail.com Christian Nurtanto Putra christian.nurtanto@student.unud.ac.id Kevin Ivandi kevin.ivandi@gmail.com Kadek Adit Wiryadana aditwiryadana@unud.ac.id Pande Made Wisnu Tirtayasa wisnu_tirtayasa@unud.ac.id Firman Pribadi firmanpribadi@umy.ac.id <p>[This corrects the article DOI: 10.13181/mji.oa.226140]</p> 2023-04-18T00:00:00+07:00 Copyright (c) 2023 Gede Wirya Kusuma Duarsa, Christian Nurtanto Putra, Kevin Ivandi, Kadek Adit Wiryadana, Pande Made Wisnu Tirtayasa, Firman Pribadi https://mji.ui.ac.id/journal/index.php/mji/article/view/6931 Acknowledgment of Reviewers 2023-04-19T09:23:48+07:00 Medical Journal of Indonesia mjioffice01@gmail.com 2023-04-18T00:00:00+07:00 Copyright (c) https://mji.ui.ac.id/journal/index.php/mji/article/view/6930 Front & Back Matter 2023-04-19T09:23:48+07:00 Medical Journal of Indonesia mjioffice01@gmail.com 2023-04-18T00:00:00+07:00 Copyright (c)