Antioxidant properties of flavonoids
DOI:
https://doi.org/10.13181/mji.v23i4.1015Keywords:
antioxidant, flavonoids, oxidative stressAbstract
Flavonoids represent a remarkable group of plant secondary metabolites and have long been used as traditional medicines with scientifically proven pharmacological benefits. They serve vast-ranging medicinal activities that may lead drug discovery with novel and potential therapeutic evidence. Latest research magnifies primarily functional activity of flavonoids as antioxidant against oxidative stress. This review enlightens the prospective role of flavonoids as antioxidant.
Downloads
References
Alfadda AA, Sallam RM. Reactive oxygen species in health and disease. Journal of Biomedicine and Biotechnology. 2012:1-14. http://dx.doi.org/10.1155/2012/936486
Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and Antioxidant defense. World Allergy Organ J. 2012;5(1):9-19. http://dx.doi.org/10.1097/WOX.0b013e3182439613
Sandhar HK, Kumar B, Prasher S, Tiwari P, Salhan M, Sharma P. A review of phytochemistry and pharmacology of flavonoids. Int Pharm Sci. 2011;1(1):25-41.
Kugelmass IN. Vitamin P in vascular purpura. JAMA. 1940;115(7):519-20. http://dx.doi.org/10.1001/jama.1940.02810330025009
Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. ScientificWorldJournal. 2013;2013:162750. http://dx.doi.org/10.1155/2013/162750
Procházková D, Bousová I, Wilhelmová N. Antioxidant and prooxidant properties of flavonoids. Fitoterapia. 2011;82(4):513-23. http://dx.doi.org/10.1016/j.fitote.2011.01.018
Male?ev D, Kunti V. Investigation of metal-flavonoid chelates and the determination of flavonoids via metal-flavonoid complexing reactions. J Serb Chem Soc 2007;72(10):921-39. http://dx.doi.org/10.2298/JSC0710921M
Bubols GB, Vianna Dda R, Medina-Remon A, von Poser G, Lamuela-Raventos RM, Eifler-Lima VL, et al. The antioxidant activity of coumarins and flavonoids. Mini Rev Med Chem. 2013;13(3):318-34. http://dx.doi.org/10.2174/138955713804999775
Ami? D, Davidovi?-Ami? D, Beslo D, Rastija V, Luci? B, Trinajsti? N. SAR and QSAR of the antioxidant activity of flavonoids. Curr Med Chem. 2007;14(7):827-4. http://dx.doi.org/10.2174/092986707780090954
Dugas AJ Jr, Casta-eda-Acosta J, Bonin GC, Price KL, Fischer NH, Winston GW. Evaluation of the total peroxyl radical-scavenging capacity of flavonoids: structure-activity relationships. J Nat Prod. 2000;63(3):327-31. http://dx.doi.org/10.1021/np990352n
Santos MR, Mira L. Protection by flavonoids against the peroxynitrite-mediated oxidation of dihydrorhodamine. Free Radic Res. 2004 Sep;38(9):1011-8. http://dx.doi.org/10.1080/10715760400003384
Moalin M, van Strijdonck GPF, Beckers M, Hagemen GJ, Borm PJ, Bast A, et al. A planar conformation and the hydroxyl groups in the B and C rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives. Molecules. 2011;16(11):9636-50. http://dx.doi.org/10.3390/molecules16119636
Celik H, Arinç E Evaluation of the protective effects of quercetin, rutin, resveratrol, naringenin and trolox against idarubicin-induced DNA damage. J Pharm Pharm Sci. 2010;13(2):231-41.
Heijnen CG, Haenen GR, van Acker FA, van der Vijgh WJ, Bast A. Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. Toxicol in Vitro. 2001;15(1):3-6. http://dx.doi.org/10.1016/S0887-2333(00)00053-9
Wiegand H, Wagner AE, Boesch-Saadatmandi C, Kruse HP, Kulling S, Rimbach G. Effect of dietary genistein on Phase II and antioxidant enzymes in rat liver. Cancer Genomics Proteomics. 2009;6(2):85-92.
Lee-Hilz YY, Boerboom AM, Westphal AH, Berkel WJ, Aarts JM, Rietjens IM. Pro-oxidant activity of flavonoids induces EpRE-mediated gene expression. Chem Res Toxicol. 2006;19(11):1499-505. http://dx.doi.org/10.1021/tx060157q
Wolfe KL, Liu RH. Structure-activity relationships of flavonoids in the cellular antioxidant activity assay. J Agric Food Chem. 2008;56(18):8404-11. http://dx.doi.org/10.1021/jf8013074
Wen X, Walle T. Methylated flavonoids have greatly improved intestinal adsorption and metabolic stability. Drug Metab Dispos. 2006;34(10):1786-92. http://dx.doi.org/10.1124/dmd.106.011122
Walle T, Ta N, Kawamori T, Wen X, Tsuji PA, Walle UK. Cancer chemopreventive properties of orally bioavailable flavonoids - methylated versus unmethylated flavones. Biochem Pharmacol. 2007;73(9):1288-96. http://dx.doi.org/10.1016/j.bcp.2006.12.028
Liu H, Guo X, Chu Y, Lu S. Heart protective effects and mechanism of quercetin preconditioning on anti-myocardial ischemia reperfusion (IR) injuries in rats. Gene. 2014;545(1):149-55. http://dx.doi.org/10.1016/j.gene.2014.04.043
Ramirez-Sanchez I, Maya L, Ceballos G, Villarreal F. (-)-Epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways. Hypertension. 2010;55(6):1398-405. http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.147892
Lee YJ, Suh KS, Choi MC, Chon S, Oh S, Woo JT, et al. Kaempferol protects HIT-T15 pancreatic beta cells from 2-deoxy-D-ribose induced oxidative damage. Phytother Res. 2010;24(3):419-23. http://dx.doi.org/10.1002/ptr.2983
Soto C, Recoba R, Barron H, Alvarez C, Favari L. Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas. Comp Biochem Physiol C Toxicol Pharmacol. 2003;136(3):205-12. http://dx.doi.org/10.1016/S1532-0456(03)00214-X
Mandel SA, Avramovich-Tirosh Y, Reznichenko L, Zheng H, Weinreb O, Amit T, et al. Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway Neurosignals. 2005;14(1-2):46-60. http://dx.doi.org/10.1159/000085385
Weinreb O, Mandel S, Amit T, Youdim MB. Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. J Nutr Biochem. 2004;15(9):506-16. http://dx.doi.org/10.1016/j.jnutbio.2004.05.002
Samy RP, Gopalakrishnakone P, Ignacimuthu S. Anti-tumor promoting potential of luteolin against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats. Chem Biol Interact. 2006;164(1-2):1-14. http://dx.doi.org/10.1016/j.cbi.2006.08.018
Hussein RH, Khalifa FK. The protective role of ellagitannins flavonoids pretreatment against N-nitrosodiethylamine induced-hepatocellular carcinoma. Saudi Journal of Biological Sciences. 2014. http://dx.doi.org/10.1016/j.sjbs.2014.03.004
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with Medical Journal of Indonesia agree to the following terms:
- Authors retain copyright and grant Medical Journal of Indonesia right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial License that allows others to remix, adapt, build upon the work non-commercially with an acknowledgment of the work’s authorship and initial publication in Medical Journal of Indonesia.
- Authors are permitted to copy and redistribute the journal's published version of the work non-commercially (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Medical Journal of Indonesia.