Total serum IgE levels among adults patients with intermittent and persistent allergic asthmas
DOI:
https://doi.org/10.13181/mji.v27i4.2910Keywords:
allergic asthma, intermittent asthma, persistent asthma, total serum IgE levelAbstract
Background: Obesity with knee osteoarthritis (OA) is related to chronic pain causing physical inactivity that leads to decreased cardiorespiratory endurance and quality of life. Aquatic and land-based exercises are effective in improving physical activity. The aim of this study is to compare between aquatic and land-based exercise to improve cardiorespiratory endurance and quality of life in obese patients with knee osteoarthritis.Methods: A single-blind, randomized, controlled trial was conducted on thirty-three obese patients with knee OA who visited Obesity Clinic of Medical Rehabilitation Cipto Mangunkusumo Hospital, from October 2016 to January 2017, subjects were divided into aquatic or land-based exercise group. Aerobic and knee-strengthening exercises were given. Cardiorespiratory endurance was assessed using the Borg Scale, whereas both the BORG CR-10 and SF-36 questionnaires were used to assess quality of life.
Results: After intervention, there were significant improvements in the land-based exercise group in the rating of perceived exertion (p=0.02), role limitations due to physical health (p=0.024), role limitations due to emotional problems (p=0.041), energy/fatigue (p=0.016), and the decline in pain (p=0.049) parameters. While in the aquatic exercise, there were significant improvements in leg fatigue (p=0.016), energy/fatigue (p=0.025), emotional well-being (p<0.001), and general health (p=0.045) parameters. Despite this, there were no significant differences between two groups regarding cardiorespiratory endurance and quality of life.
Conclusion: This study found that patients could start aquatic exercise to reduce leg fatigue and enhance general health and energy. After that, exercise could be continued in land-based settings to improve cardiorespiratory endurance and quality of life.
Downloads
References
Reddel HK, Bateman ED, Becker A, Boulet LP, Cruz AA, Drazen JM, et al. A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J. 2015;46(3):622–39. https://doi.org/10.1183/13993003.00853-2015
Global Initiative on Asthma (GINA) [Internet]. global strategy for asthma management and prevention. [updated 2015; cited 2017 May] Downloaded from: ginasthma.org/wp-content/uploads/2016/01/GINA_Report_2015_Aug11-1.
U.S. Department of Health and Human Services. The National Heart, Lung, and Blood Institute. Guidelines for the diagnosis and management of asthma-expert panel report 3. Bethesda: NHLBI Health Information Center; 2007.
Schatz M, Rosenwasser L. The allergic asthma phenotype. J Allergy Clin Immunol Pract. 2014;2(6):645–8. https://doi.org/10.1016/j.jaip.2014.09.004
Dullaers M, De Bruyne R, Ramadani F, Gould HJ, Gevaert P, Lambrecht BN. The who, where, and when of IgE in allergic airway disease. J Allergy Clin Immunol. 2012;129(3):635–45. https://doi.org/10.1016/j.jaci.2011.10.029
Borish L, Chipps B, Deniz Y, Gujrathi S, Zheng B, Dolan CM, et al. Total serum IgE levels in a large cohort of patients with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol. 2005;95(3):247–53. https://doi.org/10.1016/S1081-1206(10)61221-5
Zetterström O, Johansson SG. IgE concentrations measured by PRIST® in serum of healthy adults and in patients with respiratory allergy. A diagnostic approach. Allergy. 1981;36(8):537–47. https://doi.org/10.1111/j.1398-9995.1981.tb01871.x
Woszczek G, Kowalski ML, Borowiec M. Association of asthma and total IgE levels with human leucocyte antigen–DR in patients with grass allergy. Eur Respir J. 2002;20(1):79–85. https://doi.org/10.1183/09031936.02.01002001
Barnes PJ, Adcock IM. How do corticosteroids work in asthma? Ann Intern Med. 2003;139(5 Pt 1):359–70. https://doi.org/10.7326/0003-4819-139-5_Part_1-200309020-00012
Matsui EC, Sampson HA, Bahnson HT, Gruchalla RS, Pongracic JA, Teach SJ, et al. Allergen-specific IgE as a biomarker of exposure plus sensitization in inner-city adolescents with asthma. Allergy. 2010;65(11):1414–22. https://doi.org/10.1111/j.1398-9995.2010.02412.x
Sandeep T, Roopakala MS, Silvia CR, Chandrashekara S, Rao M. Evaluation of serum immunoglobulin E levels in bronchial asthma. Lung India. 2010;27(3):138–40. https://doi.org/10.4103/0970-2113.68312
Chowdary VS, Vinaykumer EC, Rao JJ, Rao R, Babu KR, Rangamani V. A study on serum IgE and eosinophils in respiratory allergy patients. Indian J Allergy Asthma Immunol. 2003;17(1):21–4.
Shin HD, Kim LH, Park BL, Jung JH, Kim JY, Chung IY, et al. Association of Eotaxin gene family with asthma and serum total IgE. Hum Mol Gen. 2003;12(11):1279–85. https://doi.org/10.1093/hmg/ddg142
Al-Amri M, Al Rawas OA, Al Riyami BM, Richens ER. Atopy in Omani patients with asthma. J Sci Res Med Sci. 2002;4(1–2):15–23.
Chung KF. Neutrophilic asthma: a distinct target for treatment? Lancet Respir Med. 2016;4(10):765–67. https://doi.org/10.1016/S2213-2600(16)30232-6
Fahy JV. Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc. 2009;6(3):256–9. https://doi.org/10.1513/pats.200808-087RM
Pavord ID, Brightling CE, Woltmann G, Wardlaw AJ. Non-eosinophilic corticosteroid unresponsive asthma. Lancet. 1999;353(9171):2213–14. https://doi.org/10.1016/S0140-6736(99)01813-9
Chang ML, Ciu C, Liu YH, Pei LC, Shao B. Analysis of total immunoglobulin E and specific immunoglobulin E of 3,721 patients with allergic disease. Biomed Rep. 2015;3(4):573–7. https://doi.org/10.3892/br.2015.455
Bell RG. IgE, allergies and helminth parasites: a new perspective on an old conundrum. Immunol Cell Biol. 1996;74(4):337–45. https://doi.org/10.1038/icb.1996.60
Platts-Mills TA. The role of immunoglobulin E in allergy and asthma. Am J Respir Crit Care Med. 2001;164(8 Pt 2):S1–5. https://doi.org/10.1164/ajrccm.164.supplement_1.2103024
Anupama N, Sharma MV, Nagaraja HS, Bhat MR. The serum immunoglobulin e level reflects the severity of bronchial asthma. Thai J Physiol Sci. 2005;18(3):35–40.
Dávila I, Valero A, Entrenas LM, Valveny N, Herráez L, SIGE Study Group. Relationship between serum total IgE and disease severity in patients with allergic asthma in Spain. J Investig Allergol Clin Immunol. 2015;25(2):120–7.
Published
How to Cite
Issue
Section
License
Authors who publish with Medical Journal of Indonesia agree to the following terms:
- Authors retain copyright and grant Medical Journal of Indonesia right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial License that allows others to remix, adapt, build upon the work non-commercially with an acknowledgment of the work’s authorship and initial publication in Medical Journal of Indonesia.
- Authors are permitted to copy and redistribute the journal's published version of the work non-commercially (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Medical Journal of Indonesia.
