Retinal vascular caliber changes after laser photocoagulation in diabetic retinopathy

  • Habibah Setyawati Muhiddin Department of Ophthalmology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia https://orcid.org/0000-0003-3019-2691
  • Idayani Panggalo Department of Ophthalmology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonessia https://orcid.org/0000-0002-8186-8279
  • Andi Muhammad Ichsan Department of Ophthalmology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia https://orcid.org/0000-0002-8844-2211
  • Budu Department of Ophthalmology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia
  • Emanuele Trucco VAMPIRE Project, Computing (SSEN), University of Dundee, Dundee, United Kingdom
  • John Ellis Ninewells NHS Hospital and Medical School, Dundee, United Kingdom
Keywords: diabetic retinopathy, laser photocoagulation, retinal vascular caliber
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Abstract

BACKGROUND Diabetic retinopathy causes vascular dilatation caused by hypoxia, whereas oxygen tension improvement leads to retinal vessels narrowing. Given that laser photocoagulation aims to increase the oxygen tension in the retina, we hypothesized that the narrowing of vessel caliber after the treatment could be possibly demonstrated. This study aimed to assess the changes in the caliber of retinal vessels before and after laser photocoagulation in diabetic retinopathy.

METHODS This research was a prospective cohort study on the treatment of diabetic retinopathy by laser photocoagulation, and it was conducted at Universitas Hasanuddin Hospital, Makassar, Indonesia between November 2017–April 2018. Retinal vascular caliber changes were analyzed before and 6–8 weeks after photocoagulation in 30 diabetic eyes. Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured using the vessel assessment and measurement platform software for images of the retina (VAMPIRE) manual annotation tool.

RESULTS A significant decrease of CRVE was observed after laser photocoagulation (p<0.001), but CRAE was not reduced significantly (p = 0.067). No difference was recorded between CRVE and CRAE post-laser photocoagulation (p = 0.14), implying a reduction in vein caliber toward normal in the treated eyes.

CONCLUSIONS Laser photocoagulation decreases the CRVE in diabetic retinopathy despite the absence of changes in the grade of diabetic retinopathy.

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Published
2020-12-29
How to Cite
1.
Muhiddin HS, Panggalo I, Ichsan AM, Budu, Trucco E, Ellis J. Retinal vascular caliber changes after laser photocoagulation in diabetic retinopathy. Med J Indones [Internet]. 2020Dec.29 [cited 2021Oct.26];29(4):366-71. Available from: https://mji.ui.ac.id/journal/index.php/mji/article/view/3806
Section
Clinical Research