Differences between several atherogenic parameters in patients with Controlled and Uncontrolled Type 2 Diabetes Mellitus

  • Ellis Susanti
  • Marsetio Donosepoetro
  • Ilhamjaya Patellongi
  • Mansyur Arif
Keywords: AIP, atherosclerosis, Diabetes Mellitus, HDL, Lp-PLA2, Ox-LDL
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Abstract

Aim to assess the differences between Atherogenic Index of Plasma (AIP), ratio of oxidized-Low Density Lipoprotein (Ox-LDL)/High Density Lipoprotein (HDL) and ratio of Lipoprotein-associated Phospholipase A2 (Lp-PLA2)/HDL in predicting the risk of coronary heart disease (CHD) in patients with controlled and uncontrolled type 2 Diabetes Mellitus (T2DM).

Methods The study was done observationally with cross sectional design. A total of 80 patients, consisted of 40 controlled and 40 uncontrolled T2DM. The serum triglyceride (TG), HDL-C, Ox-LDL, Lp-PLA2 were examined in their relationship with T2DM risk. AIP is a ratio calculated as log (TG/HDL-C).

Results AIP and ratio of Ox-LDL/HDL were significantly higher in uncontrolled than controlled T2DM (0.72 ± 0.13 vs 0.47 ± 0.22 , p < 0.001) and (1738.8 ± 625.5 vs 1418 ± 535.3, p = 0.02), but no significant difference was found in ratio of Lp-PLA2/HDL (5.09 ± 2.17 vs 5.95 ± 3.11, p = 0.16).

Conclusion AIP and ratio of Ox-LDL/HDL value were significantly higher in uncontrolled than in controlled T2DM. These parameters may be beneficial in predicting the risk of atherosclerosis in diabetic patients. (Med J Indones 2010; 19:103-8)

 

Published
2010-05-01
How to Cite
1.
Susanti E, Donosepoetro M, Patellongi I, Arif M. Differences between several atherogenic parameters in patients with Controlled and Uncontrolled Type 2 Diabetes Mellitus. Med J Indones [Internet]. 2010May1 [cited 2022Dec.5];19(2):103-8. Available from: https://mji.ui.ac.id/journal/index.php/mji/article/view/392
Section
Clinical Research

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