Antiviral treatment of COVID-19: a clinical pharmacology narrative review

  • Instiaty Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia https://orcid.org/0000-0002-8958-5441
  • I Gusti Agung Ayu Putu Sri Darmayani Postgraduate Student of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Jefman Efendi Marzuki Postgraduate Student of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia https://orcid.org/0000-0002-0776-2417
  • Ferina Angelia The Indonesian Clinical Pharmacology Association (PERDAFKI), Jakarta, Indonesia https://orcid.org/0000-0002-0220-837X
  • William The Indonesian Clinical Pharmacology Association (PERDAFKI), Jakarta, Indonesia https://orcid.org/0000-0003-2475-4934
  • Angelina Siane The Indonesian Clinical Pharmacology Association (PERDAFKI), Jakarta, Indonesia https://orcid.org/0000-0001-7964-6899
  • Lela Dwi Sary The Indonesian Clinical Pharmacology Association (PERDAFKI), Jakarta, Indonesia https://orcid.org/0000-0002-1981-5870
  • Lina Yohanes Postgraduate Student of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Reni Widyastuti The Indonesian Clinical Pharmacology Association (PERDAFKI), Jakarta, Indonesia
  • Riki Nova The Indonesian Clinical Pharmacology Association (PERDAFKI), Jakarta, Indonesia
  • Dewi Sharon Simorangkir The Indonesian Clinical Pharmacology Association (PERDAFKI), Jakarta, Indonesia
  • Lonah The Indonesian Clinical Pharmacology Association (PERDAFKI), Jakarta, Indonesia
  • Yolanda Safitri Postgraduate Student of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia https://orcid.org/0000-0001-7724-1564
  • Gestina Aliska The Indonesian Clinical Pharmacology Association (PERDAFKI), Jakarta, Indonesia
  • Anggi Gayatri Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Keywords: COVID-19, favipiravir, hydroxychloroquine, lopinavir, oseltamivir, remdesivir
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Abstract

The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 in China, has become a pandemic in March 2020. Repurposing old and relatively safe drugs becomes an advantageous option to obtain the urgently needed effective treatment. Repurposing chloroquine, hydroxychloroquine, oseltamivir, lopinavir/ritonavir, and
favipiravir, and the use of investigational drug remdesivir for treatment of COVID-19, are reviewed from the clinical pharmacology perspective, particularly its efficacy and safety. Limited clinical studies of chloroquine, hydroxychloroquine, favipiravir, and remdesivir showed some efficacy in COVID-19 treatment with tolerable adverse effects. Potential serious adverse effect of chloroquine and hydroxychloroquine is cardiac arrhythmia. Oseltamivir has no documented activity against SARS-CoV-2, while lopinavir/ritonavir showed limited efficacy in COVID-19. Currently, there is no sufficient evidence to recommend any specific anti-COVID-19 treatment. The decision to use these drugs during the COVID-19 pandemic must be based on careful consideration of the potential benefits and risks to the patient.

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Published
2020-07-18
How to Cite
1.
Instiaty, Darmayani IGAAPS, Marzuki JE, Angelia F, William, Siane A, Sary LD, Yohanes L, Widyastuti R, Nova R, Simorangkir DS, Lonah, Safitri Y, Aliska G, Gayatri A. Antiviral treatment of COVID-19: a clinical pharmacology narrative review. Med J Indones [Internet]. 2020Jul.18 [cited 2020Oct.21];29(3):332-45. Available from: https://mji.ui.ac.id/journal/index.php/mji/article/view/4652
Section
Review Article