The accuracy of warfarin dosage based on VKORC1 and CYP2C9 phenotypes in a Chinese population

Authors

  • Agustinus Wijaya
  • Jiang T. Bo
  • He Jun
  • Jiang W. Ping
  • Jiang Bin
  • Chen H. Jie
  • Yang B. Wen
  • Xu M. Zhu
  • Qiu Q. Cheng

DOI:

https://doi.org/10.13181/mji.v21i2.489

Keywords:

CYP2C9, pharmacogenetic algorithm, VKORC1, warfarin

Abstract

Background: The aim of this study is to assess the accuracy of warfarin dosage based on VKORC1 and CYP2C9 genotype in Chinese population.

Methods: Blood samples were taken from 37 patients. We compared the warfarin dosage obtained from genotype (according to www.warfarindosing.org) and treatment dosage with international normalized ratio (INR) value within 2.0-3.0.

Results: The majority of Chinese people in our study are VKORC1 homozygous AA (89.2%), rarely VKORC1 heterozygous AG and we cannot find a patient with homozygous GG. For CYP2C9 genotype, most patients have the wildtype variants (CYP2C9*2 CC and CYP2C9*3 AA). The warfarin dosage for patients with VKORC1 AA and CYP2C9*3 AC is lower than for patients with other genotype variants.

Conclusion: There is no significant difference between pharmacogenetic algorithm (www.warfarindosing.org) and our treatment dosage. Our conclusion is that the pharmacogenetic algorithm is accurate to predict the warfarin dose. (Med J Indones. 2012;21:108-12)

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Published

2012-05-01

How to Cite

1.
Wijaya A, Bo JT, Jun H, Ping JW, Bin J, Jie CH, et al. The accuracy of warfarin dosage based on VKORC1 and CYP2C9 phenotypes in a Chinese population. Med J Indones [Internet]. 2012 May 1 [cited 2025 Mar. 7];21(2):108-12. Available from: https://mji.ui.ac.id/journal/index.php/mji/article/view/489

Issue

Vol. 21 No. 2 (2012): May

Section

Clinical Research

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