Everolimus for the treatment of epithelioid hemangioma: a case report

  • Mururul Aisyi Department of Pediatric Hematology Oncology, Indonesia National Cancer Center, Dharmais Cancer Hospital, Jakarta, Indonesia https://orcid.org/0000-0001-9754-5696
  • Ayu Hutami Syarif Department of Research and Development, Indonesia National Cancer Center, Dharmais Cancer Hospital, Jakarta, Indonesia
  • Dewi Aisyah Mukarramah Department of Plastic Surgery, Indonesia National Cancer Center, Dharmais Cancer Hospital, Jakarta, Indonesia
  • Rio Hermawan Department of Radiology, Indonesia National Cancer Center, Dharmais Cancer Hospital, Jakarta, Indonesia https://orcid.org/0000-0002-8030-4674
  • Dewi Iriani Department of Anatomic Pathology, Indonesia National Cancer Center, Dharmais Cancer Hospital, Jakarta, Indonesia
Keywords: blood vessel tumor, everolimus, hemangioma
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Epithelioid hemangioma is a rare benign vascular tumor manifested as slow-growing subcutaneous or dermal nodules. A previously therapeutic strategy involved surgical excision and sclerotherapy. However, no standard treatment has been established. Here, we reported an atypical case of epithelioid hemangioma that had a locally aggressive behavior and was successfully treated with everolimus, a rapamycin analog used for cancer therapy. A 1-year-old boy presented with an ulcerated lump in the left palmar region. The imaging test results, confirmed through histopathologic examination, suggested a diagnosis of epithelioid hemangioma. Targeted therapy with everolimus was administered orally because of a minimal response to initial transarterial sclerotherapy. The patient achieved a satisfactory response with a significantly reduced lesion size and improved hand function after a 2-year follow-up. This finding showed that patients with locally aggressive forms of epithelioid hemangioma may significantly benefit from everolimus as a potential targeted therapy.


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How to Cite
Aisyi M, Syarif AH, Mukarramah DA, Hermawan R, Iriani D. Everolimus for the treatment of epithelioid hemangioma: a case report. Med J Indones [Internet]. 2021Jun.15 [cited 2024Jul.15];30(4):301-5. Available from: https://mji.ui.ac.id/journal/index.php/mji/article/view/5036
Case Report/Series