Effect of <em>arum manis</em> mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats

  • Taufik Saputra Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia https://orcid.org/0009-0009-0346-8227
  • Haidar Satya Naufal Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
  • Astika Widy Utomo Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
  • Nyoman Suci Widyastiti Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia https://orcid.org/0000-0002-4083-1293
  • Muhammad Farhan Kurniawan Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
  • Arfianty Nur Azizah Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
Keywords: cholestyramine, high-density lipoprotein, low-density lipoprotein, mango, pectin, triglyceride


BACKGROUND Dyslipidemia is characterized by an increase in low-density lipoprotein (LDL) and triglyceride (TG) levels and a decrease in high-density lipoprotein (HDL). Cholestyramine as an antidyslipidemia has several side effects, so an alternative is needed. Pectin is a natural substance with a mechanism of action similar to that of cholestyramine. Mango peel is one of the sources of pectin, containing 10–15% of this substance. This study aimed to prove the effect of arum manis mango (Mangifera indica L.) peel extract on LDL, HDL, and TG levels in dyslipidemic Sprague-Dawley rats.

METHODS 25 Sprague-Dawley rats were divided into 5 groups. All groups were given high-fat diet for the first 18 days, followed by standard feed (negative control group), cholestyramine (Sequest®) 80 mg/200 g body weight (standard treatment group), and mango peel extract (M-90 [90 mg/day], M-180 [180 mg/day], and M-360 [360 mg/day] groups) for the next 15 days. LDL and HDL levels were analyzed using the cholesterol oxidase-phenyl aminopyrazolone method and TG level using the glycerol-3-phosphate-oxidase-phenol-aminophenazone method.

RESULTS The M-360 group reduced the LDL level (p = 0.015), while the standard treatment group increased the HDL level (p = 0.042). Although significant TG level changes were found in the negative control, standard treatment, and M-360 groups (p = 0.042), the mean differences of LDL, HDL, and TG levels between groups were not significantly different (p = 0.245, 0.328, and 0.454, respectively).

CONCLUSIONS M. indica peel extract reduced LDL and TG levels at 360 mg/day.


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How to Cite
Saputra T, Naufal HS, Utomo AW, Widyastiti NS, Kurniawan MF, Azizah AN. Effect of <em>arum manis</em&gt; mango peel extract on cholesterol and triglyceride levels in dyslipidemic Sprague-Dawley rats. Med J Indones [Internet]. 2023Dec.22 [cited 2024Feb.21];32(3):157-60. Available from: https://mji.ui.ac.id/journal/index.php/mji/article/view/6960
Basic Medical Research