Antioxidant properties of flavonoids

  • Sofna D.S. Banjarnahor Pusat Penelitian Kimia-Lembaga Ilmu Pengetahuan Indonesia (LIPI) Kawasan PUSPIPTEK, Tangerang Selatan 15314
  • Nina Artanti Pusat Penelitian Kimia-Lembaga Ilmu Pengetahuan Indonesia (LIPI) Kawasan PUSPIPTEK, Tangerang Selatan 15314
Keywords: antioxidant, flavonoids, oxidative stress
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Abstract

Flavonoids represent a remarkable group of plant secondary metabolites and have long been used as traditional medicines with scientifically proven pharmacological benefits. They serve vast-ranging medicinal activities that may lead drug discovery with novel and potential therapeutic evidence. Latest research magnifies primarily functional activity of flavonoids as antioxidant against oxidative stress. This review enlightens the prospective role of flavonoids as antioxidant.

Author Biography

Sofna D.S. Banjarnahor, Pusat Penelitian Kimia-Lembaga Ilmu Pengetahuan Indonesia (LIPI) Kawasan PUSPIPTEK, Tangerang Selatan 15314
Natural Product, Food and Pharmacy

References

  1. Alfadda AA, Sallam RM. Reactive oxygen species in health and disease. Journal of Biomedicine and Biotechnology. 2012:1-14. http://dx.doi.org/10.1155/2012/936486

  2. Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O. Oxidative stress and Antioxidant defense. World Allergy Organ J. 2012;5(1):9-19. http://dx.doi.org/10.1097/WOX.0b013e3182439613

  3. Sandhar HK, Kumar B, Prasher S, Tiwari P, Salhan M, Sharma P. A review of phytochemistry and pharmacology of flavonoids. Int Pharm Sci. 2011;1(1):25-41.

  4. Kugelmass IN. Vitamin P in vascular purpura. JAMA. 1940;115(7):519-20. http://dx.doi.org/10.1001/jama.1940.02810330025009

  5. Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. ScientificWorldJournal. 2013;2013:162750. http://dx.doi.org/10.1155/2013/162750

  6. Procházková D, Bousová I, Wilhelmová N. Antioxidant and prooxidant properties of flavonoids. Fitoterapia. 2011;82(4):513-23. http://dx.doi.org/10.1016/j.fitote.2011.01.018

  7. Maleśev D, Kunti V. Investigation of metal-flavonoid chelates and the determination of flavonoids via metal-flavonoid complexing reactions. J Serb Chem Soc 2007;72(10):921-39. http://dx.doi.org/10.2298/JSC0710921M

  8. Bubols GB, Vianna Dda R, Medina-Remon A, von Poser G, Lamuela-Raventos RM, Eifler-Lima VL, et al. The antioxidant activity of coumarins and flavonoids. Mini Rev Med Chem. 2013;13(3):318-34. http://dx.doi.org/10.2174/138955713804999775

  9. Amić D, Davidović-Amić D, Beslo D, Rastija V, Lucić B, Trinajstić N. SAR and QSAR of the antioxidant activity of flavonoids. Curr Med Chem. 2007;14(7):827-4. http://dx.doi.org/10.2174/092986707780090954

  10. Dugas AJ Jr, Casta-eda-Acosta J, Bonin GC, Price KL, Fischer NH, Winston GW. Evaluation of the total peroxyl radical-scavenging capacity of flavonoids: structure-activity relationships. J Nat Prod. 2000;63(3):327-31. http://dx.doi.org/10.1021/np990352n

  11. Santos MR, Mira L. Protection by flavonoids against the peroxynitrite-mediated oxidation of dihydrorhodamine. Free Radic Res. 2004 Sep;38(9):1011-8. http://dx.doi.org/10.1080/10715760400003384

  12. Moalin M, van Strijdonck GPF, Beckers M, Hagemen GJ, Borm PJ, Bast A, et al. A planar conformation and the hydroxyl groups in the B and C rings play a pivotal role in the antioxidant capacity of quercetin and quercetin derivatives. Molecules. 2011;16(11):9636-50. http://dx.doi.org/10.3390/molecules16119636

  13. Celik H, Arinç E Evaluation of the protective effects of quercetin, rutin, resveratrol, naringenin and trolox against idarubicin-induced DNA damage. J Pharm Pharm Sci. 2010;13(2):231-41.

  14. Heijnen CG, Haenen GR, van Acker FA, van der Vijgh WJ, Bast A. Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups. Toxicol in Vitro. 2001;15(1):3-6. http://dx.doi.org/10.1016/S0887-2333(00)00053-9

  15. Wiegand H, Wagner AE, Boesch-Saadatmandi C, Kruse HP, Kulling S, Rimbach G. Effect of dietary genistein on Phase II and antioxidant enzymes in rat liver. Cancer Genomics Proteomics. 2009;6(2):85-92.

  16. Lee-Hilz YY, Boerboom AM, Westphal AH, Berkel WJ, Aarts JM, Rietjens IM. Pro-oxidant activity of flavonoids induces EpRE-mediated gene expression. Chem Res Toxicol. 2006;19(11):1499-505. http://dx.doi.org/10.1021/tx060157q

  17. Wolfe KL, Liu RH. Structure-activity relationships of flavonoids in the cellular antioxidant activity assay. J Agric Food Chem. 2008;56(18):8404-11. http://dx.doi.org/10.1021/jf8013074

  18. Wen X, Walle T. Methylated flavonoids have greatly improved intestinal adsorption and metabolic stability. Drug Metab Dispos. 2006;34(10):1786-92. http://dx.doi.org/10.1124/dmd.106.011122

  19. Walle T, Ta N, Kawamori T, Wen X, Tsuji PA, Walle UK. Cancer chemopreventive properties of orally bioavailable flavonoids - methylated versus unmethylated flavones. Biochem Pharmacol. 2007;73(9):1288-96. http://dx.doi.org/10.1016/j.bcp.2006.12.028

  20. Liu H, Guo X, Chu Y, Lu S. Heart protective effects and mechanism of quercetin preconditioning on anti-myocardial ischemia reperfusion (IR) injuries in rats. Gene. 2014;545(1):149-55. http://dx.doi.org/10.1016/j.gene.2014.04.043

  21. Ramirez-Sanchez I, Maya L, Ceballos G, Villarreal F. (-)-Epicatechin activation of endothelial cell endothelial nitric oxide synthase, nitric oxide, and related signaling pathways. Hypertension. 2010;55(6):1398-405. http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.147892

  22. Lee YJ, Suh KS, Choi MC, Chon S, Oh S, Woo JT, et al. Kaempferol protects HIT-T15 pancreatic beta cells from 2-deoxy-D-ribose induced oxidative damage. Phytother Res. 2010;24(3):419-23. http://dx.doi.org/10.1002/ptr.2983

  23. Soto C, Recoba R, Barron H, Alvarez C, Favari L. Silymarin increases antioxidant enzymes in alloxan-induced diabetes in rat pancreas. Comp Biochem Physiol C Toxicol Pharmacol. 2003;136(3):205-12. http://dx.doi.org/10.1016/S1532-0456(03)00214-X

  24. Mandel SA, Avramovich-Tirosh Y, Reznichenko L, Zheng H, Weinreb O, Amit T, et al. Multifunctional activities of green tea catechins in neuroprotection. Modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway Neurosignals. 2005;14(1-2):46-60. http://dx.doi.org/10.1159/000085385

  25. Weinreb O, Mandel S, Amit T, Youdim MB. Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases. J Nutr Biochem. 2004;15(9):506-16. http://dx.doi.org/10.1016/j.jnutbio.2004.05.002

  26. Samy RP, Gopalakrishnakone P, Ignacimuthu S. Anti-tumor promoting potential of luteolin against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats. Chem Biol Interact. 2006;164(1-2):1-14. http://dx.doi.org/10.1016/j.cbi.2006.08.018

  27. Hussein RH, Khalifa FK. The protective role of ellagitannins flavonoids pretreatment against N-nitrosodiethylamine induced-hepatocellular carcinoma. Saudi Journal of Biological Sciences. 2014. http://dx.doi.org/10.1016/j.sjbs.2014.03.004

Published
2015-01-27
How to Cite
1.
Banjarnahor SD, Artanti N. Antioxidant properties of flavonoids. Med J Indones [Internet]. 2015Jan.27 [cited 2024Apr.20];23(4):239-44. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/1015
Section
Review Article