Interleukin-18 levels in adult dengue fever and dengue hemorrhagic fever

  • Herdiman T. Pohan
  • Suhendro Suhendro
  • Rika Bur
  • Asnath Matondang
  • Samsuridjal Djauzi
  • Katsuya Inada
  • Shigeatsu Endo
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Abstract

Interleukin (IL)-18 ( interferon-γ inducing factor) is one of cytokines, produced by macrophage, take part in differentiation T-helper (Th) to Th1 and interferon γ producing. T helper1 play role in cellular immunity especially in viral infection include dengue. A descriptive correlative study has done to know the correlation between IL-18 levels and disease severity in admitted dengue fever (DF) and dengue hemorrhagic fever (DHF) patients. In 42 subjects consist of 20 (47.6%) DF and 22 (53.3%) DHF (grade I to IV WHO criteria, 1999) showed that IL-18 levels significantly higher in DHF than DF patients. There are significant correlation between IL-18 levels and hematocrit and low platelet value. This study supports the possible role of IL-18 in pathogenesis DHF in adults. (Med J Indones 2004; 13: 86-9)

Keywords: dengue, dengue hemorrhagic fever, IL-18, cytokine, pathogenesis
Published
2004-05-01
How to Cite
1.
Pohan HT, Suhendro S, Bur R, Matondang A, Djauzi S, Inada K, Endo S. Interleukin-18 levels in adult dengue fever and dengue hemorrhagic fever. Med J Indones [Internet]. 2004May1 [cited 2020Mar.31];13(2):86-9. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/136
Section
Clinical Research

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