Targeting pro-protein convertase subtilisin kexin-9 as a novel therapy of hypercholesterolemia

  • Bambang Dwiputra Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta
  • Anwar Santoso Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta
  • Kian K. Poh Department of Cardiology, National University Heart Centre
Keywords: low density lipoprotein, PCSK-9 inhibitor, pro-protein convertase subtilisin kexin-9
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Abstract

Reducing low density lipoprotein (LDL) cholesterol level is an established primary and secondary prevention strategy for coronary heart disease. However, not all patients are able to achieve their LDL targets as recommended by the guidelines. Over the last 10 years, high plasma LDL level is known to be associated with a higher level of pro-protein convertase subtilisin kexin-9 (PCSK-9). Loss-of-function mutations in the PCSK-9 gene is associated with lower plasma LDL level and cardiovascular risk. Since its discovery in 2003, PCSK-9 has triggered many researchers to design a PCSK-9 inhibitor to reduce LDL cholesterol through competitive inhibition of this molecule. Some phase III clinical trials have showed promising results of PCSK-9 inhibitor efficacy in lowering LDL level and improving clinical outcome. This article aims to discuss the role of PCSK-9 in LDL metabolism and the efficacy of PCSK-9 inhibitor in reducing plasma LDL level.

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Author Biographies

Bambang Dwiputra, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta
Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular center Harapan Kita Jakarta
Anwar Santoso, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta
Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular center Harapan Kita Jakarta

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Published
2017-08-18
How to Cite
1.
Dwiputra B, Santoso A, Poh KK. Targeting pro-protein convertase subtilisin kexin-9 as a novel therapy of hypercholesterolemia. Med J Indones [Internet]. 2017Aug.18 [cited 2019Aug.26];26(2):152-7. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/1443
Section
Review Article