Honey clinically stimulates granulation and epithelialization in chronic wounds: a report of two cases
DOI:
https://doi.org/10.13181/mji.v27i1.1457Keywords:
chronic wounds, epithelialization, granulation, honeyAbstract
Various studies have been widely reintroduced honey as a wound dressing in chronic wound treatment. However, its utilization in Indonesia is still very limited. This study reported the effect of honey in stimulating the epithelialization and granulation on chronic wound treatment in our center. Two chronic wound cases, diabetic foot ulcer patient and gangrenous extravasation due to sodium bicarbonate, were daily treated with honey applications. After six-week evaluation, clinically the tissue granulation and epithelization were seen at the edge of the observed wounds and decreased the wound size significantly with no reported side effects. Honey clinically stimulates the epithelialization and granulation on chronic wound treatment.Downloads
References
Torre, JI. Medscape [Internet]. Chronic Wound. [cited 2015 Dec 11]. Available from: http://emedicine.medscape.com/article/1298452-overview#showall.
Diegelmann RF, Evans MC. Wound Healing: an overview of acute, fibrotic and delayed healing. Front in Biosci. 2004;9:283–9. https://doi.org/10.2741/1184
Gurtner GC. Wound Healing: Normal and Abnormal. In: Grabbdan S., editor. Plastic Surgery 6 th Edition. Philadelphia: Lippincott. 2007;15–22.
MacKay D, Miller AL. Nutritional Support for wound healing. Altern Med Rev. 2003; 8(4):359–77.
Molan P, Rhodes T. Honey: A biologic wound dressing. Wounds. 2015;27(6):141–51.
Molan PC. Re-introducing honey in the management of wounds and ulcers - theory and practice. Ostomy Wound Manage. 2002;48(11):28–40.
Sudjatmiko G. Madu untuk obat luka kronis. Jakarta: Yayasan Khasanah Kebajikan. 2011; 7–31. Indonesian.
Ingle R, Levin J, Polinder K. Wound healing with honey – a randomized controlled trial. S Afr Med J. 2006;96(9):831–5.
Zbuchea A. Up-to-date use of honey for burns treatment. Ann Burns Fire Disasters. 2014;27(2):22–30.
Mandal MD, Mandal S. Honey: Its medicinal property and antibacterial activity. Asian Pac J Trop Biomed. 2011;1(2):154–60. https://doi.org/10.1016/S2221-1691(11)60016-6
Yaghoobi R, Kazerouni A, Kazerouni O. Evidence for clinical use of honey in wound healing as an anti-bacterial, anti-inflammatory anti-oxidant and anti-viral agent: a review. Jundishapur J Nat Pharm Prod. 2013;8(3):100–4. https://doi.org/10.17795/jjnpp-9487
Zhao G, Usui ML, Lippman SI, James GA, Stewart PS, Fleckman P, et al. Biofilms and inflammation in chronic wounds. Adv Wound Care (New Rochelle). 2013;2(7):389–99. https://doi.org/10.1089/wound.2012.0381
Henriques A, Jackson S, Cooper R, Burton N. Free radical production and quenching in honeys with wound healing potential. J Antimicrobial Chemother. 2006;58(4):773–7. https://doi.org/10.1093/jac/dkl336
Molan PC. Debridement of wounds with honey. J Wound Technol. 2009;5:12–17.
Witman CE, Downs BW. Topical honey for scalp defects: an alternative to surgical scalp reconstruction. Plast Reconstr Surg Glob Open. 2015;3(5):e393. https://doi.org/10.1097/GOX.0000000000000361
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