The impact of Î²-hCG on placental angiogenesis in pre-eclampsia
Numerous factors, such as VEGF and intra-placental oxygenation, can influence placental angiogenic activity. Early in the normalÂ gestation period, Î²-hCG enhance VEGF activity to induce angiogenesis. The aims of this study were to identify the correlationÂ between Î²-hCGÂ concentration in placental culture and placental angiogenic activity in pre-eclampsia. Ten placenta samples fromÂ women with pre-eclampsia and l0 from controls (normal pregnancy) were collected. All subjects agreed to participate in this studyÂ and signed an informed consent form. Î²-hCGÂ concentration in supernatant of placental culture was measured by MicroparticleÂ Enzyme Immunoassay (MEIA) and placental angiogenic activity was measured by endothelial cell migration toward placental explantÂ (score 0-4). The results showed that the median score of placental angiogenic activity in pre-eclampsia was significantly higher thanÂ in normal pregnancy (p<0.05). Concentration of Î²-ahCGÂ in pre-eclampsia was significantly higher than in normal pregnancyÂ (p<0.001). hCG concentration in placental culture was positively correlated to placental angiogenic activity both in pre-eclampsiaÂ (r=+0.50) and in normal pregnancy (r=+0.57). Althouglt the correlations were weak, Î²-hCGÂ is considered one of the factors thatÂ influence placental angiogenic activity. (Med J Indones 2005; 14: 67-70)
Keyvords: angiogenesis, Î²-hCG, plocenta, pre-eclampsia
Copyright (c) 2005 Sri B. Subakir, Tri Jauhari, Pramita Iriana, Minarma Siagian, Sutarmo Setiadji
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