The potential of carbonate apatite as an alternative bone substitute material

  • Ahmad Jabir Rahyussalim Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Sugeng Supriadi Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Depok
  • Aldo Fransiskus Marsetio Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Pancar Muhammad Pribadi Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Depok
  • Bambang Suharno Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Depok
Keywords: bone graft, bone substitute, bone scaffold, calcium phosphate, carbonate apatite, orthopedic biomaterials
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Bone reconstructive surgery has become a common procedure, and bone transplantation has become the second most frequently performed tissue transplantation procedure worldwide. Therefore, the need for bone substitute materials has increased. Artificial bone substitutes exhibit osteoconductive properties and feature several advantages, including abundant resources, low cost, and low donor site morbidity. Carbonate apatite (CO3Ap) is a calcium phosphate ceramic that can be used as a synthetic bone graft. The carbonate content of this ceramic is similar to that of bone apatite. In this review, we show that carbonate apatite can be degraded given its chemical reactivity in a weakly acidic environment and through osteoclast resorption. Moreover, it is osteoconductive and promotes bone tissue formation without fibrotic tissue formation. Additionally, microstructural analysis revealed that new bone tissue is formed within the bone graft itself.


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How to Cite
Rahyussalim AJ, Supriadi S, Marsetio AF, Pribadi PM, Suharno B. The potential of carbonate apatite as an alternative bone substitute material. Med J Indones [Internet]. 2019May8 [cited 2020Aug.5];28(1):92-7. Available from:
Review Article