Short-term intravenous zoledronic acid in severe osteogenesis imperfecta : A report of three siblings of children

  • Hadyanto Lim
  • Umar Zein
  • Yahwardiah Siregar
  • Blondina Marpaung
  • Jaminsen Sinaga
Abstract viewed: 484 times
PDF downloaded: 361 times

Abstract

This report documented the clinical and biochemical side effects on the first dose of intravenous zoledronic acid therapy in three siblings with severe osteogenesis imperfecta. Zoledronic acid was administered in 50 ml 0.9% saline solution over a period of 30 minutes. All patients had fever during the first 6 to 48 hours after the first infusion. There were no renal side effects, apart from asymptomatic hypocalcemia and hypophosphatemia at 48 and 72 hours after zoledronic acid infusion. The minimal clinical side effects were easily manageable. (Med J Indones 2008; 17: 127-30)

Keywords: zoledronic acid, osteogenesis imperfecta, side effects

Published
2008-05-01
How to Cite
1.
Lim H, Zein U, Siregar Y, Marpaung B, Sinaga J. Short-term intravenous zoledronic acid in severe osteogenesis imperfecta : A report of three siblings of children. Med J Indones [Internet]. 2008May1 [cited 2020Oct.21];17(2):127-30. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/310
Section
Clinical Research