Pulmonary dysfunction in obese early adolescents

  • Bambang Supriyatno
  • Irma Sapriani
  • Sri R.S. Hadinegoro
DOI: https://doi.org/10.13181/mji.v19i3.402
Keywords: early adolescents, obesity, pulmonary function test
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Abstract

Aim Obesity leads to various complications, including pulmonary dysfunction. Studies on pulmonary function of obese children are limited and the results are controversial. This study was aimed to determine proportion of pulmonary dysfunction on early adolescents with obesity and to evaluate correlation between obesity degree with pulmonary dysfunction degree.

Methods A cross-sectional study was conducted at the Department of Child Health, Medical School, University of Indonesia, from November 2007 to December 2008. Subjects were 10 to 12 year-old adolescents with obesity. Subjects underwent pulmonary function test (PFT) to assess FEV1/FVC, FEV1, FVC, V50, and V25.

Results 110 subjects fulfilled study criteria, 83 (75.5%) were male and 27 (24.5%) were female with median BMI 26.7 (22.6-54.7) kg/m2; 92 subjects (83.6%) were superobese. History of asthma and allergic rhinitis were found in 32 (29.1%) and 46 (41.8%) subjects, respectively. 64 (58.2%) subjects had abnormal PFT results consisting of restrictive type in 28 (25.5%) subjects, obstructive in 3 (2.7%), and combined type in 33 (30%). Mean FEV1, FVC, V50, and V25 values were below normal, while mean FEV1/FVC ratio was normal. There was no statistically significant correlation between BMI and PFT parameters. No significant correlation was found between degree of obesity and the severity of pulmonary dysfunction.

Conclusions Pulmonary dysfunction occurs in 58.2% obese early adolescents. The most common abnormality was combined type (30%), followed by restrictive (25.5%), and obstructive type (2.7%). There was no correlation between BMI and pulmonary function test parameters. (Med J Indones 2010;19:179-84)

References

  1. World Health Organization. Obesity: preventing and managing the global epidemic: report of a WHO consultation. Geneva: The Office of Publication, World Health Organization; 1999.

  2. Batch JA, Baur LA. Management and prevention of obesity and its complications in children and adolescents. Med J Austr. 2005;182:130-5.

  3. Djer MM. Prevalence of obesity and its influencing factors of school children in Kenari 7 and 8 elementary school, Jakarta [thesis]. Jakarta: University of Indonesia; 1998.

  4. Susanti TE. Prevalence and risk factors of obesity in school children aged 10-12 years in 5 areas of DKI Jakarta [thesis]. Jakarta: university of Indonesia; 2007.

  5. de Sousa AGP, Cercato C, Mancini MC, Halpern A. Obesity and obstructive sleep apnea-hypopnea syndrome. Obes Rev. 2008;9:340-54.

  6. Li AM, Chan D, Wong E, Yin J, Nelson EAS, Fok TF. The effects of obesity on pulmonary function. Arch Dis Child. 2003;88:361-3.

  7. Ferreti A, Giampicollo P, Cavalli A, Millic-Emili J, Tantucci C. Expiratory flow limitation and orthopnea in massively obese subjects. Chest. 2001;119:1401-8.

  8. King GG, Brown NJ, Diba C, Thorpe CW, Munoz P, Marks GB, et al. The effects of body weight on airway caliber. Eur Respir J. 2005;25:896-901.

  9. Koenig SM. Pulmonary complications of obesity. Am J Med Sci. 2001;321:249-79.

  10. Boran P, Tokuc G, Pisgin B, Oktem S, Yegin Z, Boston O. Impact of obesity on ventilatory function. J Pediatr (Rio J). 2007;83:171-6.

  11. Inselman LS, Milanese A, Deurloo A. Effect of obesity on pulmonary function in children. Pediatr Pulmonol. 1993;16:130-7.

  12. Marcus CL, Curtis S, Koerner CB, Joffe A, Serwint JR, Loughlin GM. Evaluation of pulmonary function and polysomnography in obese children and adolescents. Pediatr Pulmonol. 1996;21:176-83.

  13. Ulger Z, Demir E, Tanac R, Goksen D, Gulen F, Darcan S, et al. The effect of childhood obesity on respiratory function tests and airway hyperesponsiveness. Turk J Pediatr. 2006;48:43-50. 14. Spathopoulos D, Paraskakis E, Trypsianis G, Tsalkidis A, Arvanitidou V, Emporiadou M, et al. The effect of obesity on pulmonary lung function of school aged children in Greece. Pediatr Pulmonol. 2009;44:273-80. 15. Supriyatno BS. Obstructive sleep apnea syndrome risk factor in early adolescents with obesity: scoring system for diagnostic prediction [dissertation]. Jakarta: University of Indonesia; 2009. 16. Jubber AS. Respiratory complications of obesity. Int J Clin Pract. 2004;58:573-80.

  14. Amra B, Rahmani A, Salimi S, Mohammadzadeh Z, Golshan M. Association between asthma and body mass index in children. Iran J Allergy Asthma Immunol. 2005;4:33-7.

  15. Chow JSW, Leung ASM, Li WWS, Tse TPK, Sy HK, Leung TF. Airway inflammatory and spirometric measurements in obese children. Hong Kong Med J. 2009;15:364-52.

  16. El Helaly N, Kamel Y, Elaziz EA, Elwan A, Nabih M. Childhood obesity and asthma severity: is there a link? J Biol Sci. 2009;9:259-63.

  17. von Mutius E, Schwartz J, Neas LM, Dockery D, Weiss ST. Relation of body mass index to asthma and atopy in children: the National health and nutrition examination study III. Thorax. 2001;56:835-8.

  18. Wickens K, Barry D, Fiezema A, Rhodius D, Bone M, Purdie G, et al. Obesity and asthma in 11-12 years old New Zealand in 1989 and 2000. Thorax. 2005;60:7-12.

  19. Weiss ST. Obesity: insight into the origins of asthma. Nat Immunol. 2005;6:537-9.

  20. Garenc C, Perusse L, Chagnon YC, Rankinen T, Gagnon J, Borecki IB, et al. Effects of beta2-adrenergic receptor gene variants on adiposity: the HERITAGE Family Study. Obes Res. 2003;11:612-8.

  21. Matricardi PM, Gruber C, Wahn U, Lau S. The asthma-obesity link in childhood: open questions, complex evidence, a few answers only. Clin Exp Allergy. 2007;37:476-84.

  22. Tantisira KG, Litanjua AA, Weiss ST, Fuhlbrigge AL. Association of body mass with pulmonary function in the childhood asthma management program (CAMP). Thorax. 2003;58:1036-41.

  23. Goran MI. Measurement issues related to studies of childhood obesity: assessment of body composition, body fat distribution, physical activity, and food intake. Pediarics. 1998;101:505-18.

Published
2010-08-01
How to Cite
1.
Supriyatno B, Sapriani I, Hadinegoro SR. Pulmonary dysfunction in obese early adolescents. Med J Indones [Internet]. 2010Aug.1 [cited 2024Apr.19];19(3):179-84. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/402
Issue
Vol. 19 No. 3 (2010): August
Section
Clinical Research

Copyright (c) 2010 Bambang Supriyatno, Irma Sapriani, Sri R.S. Hadinegoro

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