The association of plasminogen activator inhibitor-1 level with ischemic stroke (preliminary study)

  • Yenny Surjawan
  • Rahajuningsih D. Setiabudy
  • Marzuki Suryaatmadja
  • Teguh A.S. Ranakusuma
Keywords: ischemic stroke, plasminogen activator inhibitor-1, stroke risk factors
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Aim Recently, increased plasminogen activator inhibitor-1 (PAI-1) has been known a risk factor for ischemic heart disease. However, the association of increased PAI-1 level with ischemic stroke remains unclear. The aim of this study was to analyze the association of PAI-1 level with ischemic stroke.

Methods By case control design we involved 38 ischemic stroke and 38 risky-matched control subjects who fulfilled the criteria. The PAI-1 level was determined by ELISA method using Asserachrom PAI-1 from Stago.

Results High PAI-1 level was found more frequent in ischemic stroke subjects than in control subjects (21.1% vs. 7.9 % with OR 3.1; 95 % CI 0.757 - 12.790). The analysis of all studied subjects showed that there was a weak negative correlation between PAI-1 level and age (r = -0.4; P = 0.000). High PAI-1 level was found more frequent in younger (40 - 58 years old) than in the older subjects (60 - 84 years old) (20% vs. 9.8 %) (p=0.004).

Conclusion The result of this preliminary study suggested an association between PAI-1 level and ischemic stroke in younger age. Further study with larger subjects is recommended to confirm this association. (Med J Indones 2009;19:158-63)


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How to Cite
Surjawan Y, Setiabudy RD, Suryaatmadja M, Ranakusuma TA. The association of plasminogen activator inhibitor-1 level with ischemic stroke (preliminary study). Med J Indones [Internet]. 2010Aug.1 [cited 2024May26];19(3):158-63. Available from:
Clinical Research