Genotype distribution of T cell receptor Î² gene in Indonesian nasopharyngeal carcinoma patients
Background: Nasopharyngeal carcinoma (NPC) is a multifactorial genetic disease, characteristically endemic and showsÂ considerable differences in its geographical distribution. Besides infection with EBV, genetic factors such as polymorphismsÂ of TCR-Î² gene contribute to the incidence of NPC. This study investigates the association of TCR-Î² gene polymorphismsÂ with individual susceptibility to develop NPC in Indonesian ethnic groups.
Methods: The study was carried out by the PCR-RFLP method using Bgl II restriction enzyme to digest TCR-Î² gene. TheÂ PCR-RFLP analysis of TCR-Î² gene was used to determine allotypes of TCR-Î² gene in NPC patients and control amongÂ ethnic Chinese and indigenous groups in the population of Indonesia.
Results: The results indicate that the distribution of TCR-Î² gene allotypes between NPC patients and controls are notÂ significantly different (p > 0.05); however, the frequency of A allele tends to increase in NPC patients. The distribution ofÂ TCR-Î² gene allotypes between Chinese ethnic group was not signifi cantly different from indigenous groups (p > 0.05).
Conclusion: The distribution of TCR-Î² gene allele between NPC group and control groups showed no difference. TheÂ distribution of TCR-Î² gene between ethnic Chinese and indigenous groups showed no difference. Polymorphisms of TCR-Î²Â gene are not associated with NPC and ethnic groups in Indonesian population. (Med J Indones 2011; 20:171-7)
Keywords: EBV, NPC, polymorphism, susceptibility, TCR-Ã gene
Copyright (c) 2011 Yurnadi Yurnadi, Purnomo Soeharso, Dwi A. Suryandari, Nukman Moeloek, R. Susworo
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