Genotype distribution of T cell receptor β gene in Indonesian nasopharyngeal carcinoma patients

  • Yurnadi Yurnadi
  • Purnomo Soeharso
  • Dwi A. Suryandari
  • Nukman Moeloek
  • R. Susworo
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Abstract

Background: Nasopharyngeal carcinoma (NPC) is a multifactorial genetic disease, characteristically endemic and shows considerable differences in its geographical distribution. Besides infection with EBV, genetic factors such as polymorphisms of TCR-β gene contribute to the incidence of NPC. This study investigates the association of TCR-β gene polymorphisms with individual susceptibility to develop NPC in Indonesian ethnic groups.

Methods: The study was carried out by the PCR-RFLP method using Bgl II restriction enzyme to digest TCR-β gene. The PCR-RFLP analysis of TCR-β gene was used to determine allotypes of TCR-β gene in NPC patients and control among ethnic Chinese and indigenous groups in the population of Indonesia.

Results: The results indicate that the distribution of TCR-β gene allotypes between NPC patients and controls are not significantly different (p > 0.05); however, the frequency of A allele tends to increase in NPC patients. The distribution of TCR-β gene allotypes between Chinese ethnic group was not signifi cantly different from indigenous groups (p > 0.05).

Conclusion: The distribution of TCR-β gene allele between NPC group and control groups showed no difference. The distribution of TCR-β gene between ethnic Chinese and indigenous groups showed no difference. Polymorphisms of TCR-β gene are not associated with NPC and ethnic groups in Indonesian population. (Med J Indones 2011; 20:171-7)

Keywords: EBV, NPC, polymorphism, susceptibility, TCR-Ã gene

Published
2011-08-01
How to Cite
1.
Yurnadi Y, Soeharso P, Suryandari DA, Moeloek N, Susworo R. Genotype distribution of T cell receptor β gene in Indonesian nasopharyngeal carcinoma patients. Med J Indones [Internet]. 2011Aug.1 [cited 2020Oct.21];20(3):171-7. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/446
Section
Basic Medical Research

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