A randomized controlled trial of combination of peppermint, lavender, and turmeric oil for antipruritic agent in pregnant women
DOI:
https://doi.org/10.13181/mji.oa.204467Keywords:
essential oils, lavender, peppermint, pregnancy, pruritus, turmericAbstract
BACKGROUND Pruritus is the most common dermatological complaint that occurs during pregnancy, which is around 14–20%. No research related to herbal products to reduce some of the characteristics of pruritus at once has been conducted. This study aimed to assess the effect of blending oil to reduce pruritus based on visual analog scale (VAS).
METHODS This was a single-blind, randomized clinical trial that included 57 pregnant women who were at 25–38 weeks of gestation, had a pruritus during pregnancy, a single pregnancy, a level I and II pruritus and a moderate to severe pruritus based on VAS. Pruritus scores were measured using VAS in both the treatment and control groups. The treatment and control groups applied blending oil and placebo, respectively, twice a day after bathing for 2 weeks. Mann–Whitney U, paired t, and chi-square tests were used for the analysis.
RESULTS Pruritus reduction in pregnant women who received blending oil was higher than those using placebo (61.08% versus 12.41%, p<0.05). 83% of subjects using blending oils had a reduction of pruritus by >25 mm. Pregnant women who used placebo had a six times greater risk of experiencing pruritus than those who used blending oil (RR = 5.8, 95% CI = 2.613–12.874).
CONCLUSIONS Blending oil can be used topically to treat a pruritus in pregnant women.
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Weisshaar E, Szepietowski JC, Dalgard FJ, Garcovich S, Gieler U, Gimenez-Arnau AM, et al. European S2k guideline on chronic pruritus. Acta Derm Venereol. 2019;99(5):469-506. https://doi.org/10.2340/00015555-3164
Mehta N, Chen KK, Kroumpouzos G. Skin disease in pregnancy: the approach of the obstetric medicine physician. Clin Dermatol. 2016;34(3):320-6. https://doi.org/10.1016/j.clindermatol.2016.02.003
Dumbell R, Matveeva O, Oster H. Circadian clocks, stress, and immunity. Front Endocrinol. 2016;7:37. https://doi.org/10.3389/fendo.2016.00037
Szczech J, Wiatrowski A, Hirnle L, Reich A. Prevalence and relevance of pruritus in pregnancy. Biomed Res Int. 2017;2017:4238139. https://doi.org/10.1155/2017/4238139
Kenyon AP, Tribe RM, Nelson-Piercy C, Girling JC, Williamson C, Seed PT, et al. Pruritus in pregnancy: a study of anatomical distribution and prevalence in relation to the development of obstetric cholestasis. Obstet Med. 2010;3(1):25-9. https://doi.org/10.1258/om.2010.090055
Kennedy DA, Lupattelli A, Koren G, Nordeng H. Safety classification of herbal medicines used in pregnancy in a multinational study. BMC Complement Altern Med. 2016;16(1):102. https://doi.org/10.1186/s12906-016-1079-z
Herro E, Jacob SE. Mentha piperita (peppermint). Dermatitis. 2010;21(6):327-9. https://doi.org/10.2310/6620.2011.10080
Patel T, Ishiuji Y, Yosipovitch G. Menthol: a refreshing look at this ancient compound. J Am Acad Dermatol. 2007;57(5):873-8. https://doi.org/10.1016/j.jaad.2007.04.008
Sienkiewicz M, G?owacka A, Kowalczyk E, Wiktorowska-Owczarek A, Jó?wiak-B?benista M, ?ysakowska M. The biological activities of cinnamon, geranium and lavender essential oils. Molecules. 2014;19(12):20929-40. https://doi.org/10.3390/molecules191220929
Giovannini D, Gismondi A, Basso A, Canuti L, Braglia R, Canini A, et al. Lavandula angustifolia mill. essential oil exerts antibacterial and anti-Inflammatory effect in macrophage mediated immune response to Staphylococcus aureus. Immunol Invest. 2016;45(1):11-28. https://doi.org/10.3109/08820139.2015.1085392
Lee HK, Park SB, Chang SY, Jung SJ. Antipruritic effect of curcumin on histamine-induced itching in mice. Korean J Physiol Pharmacol. 2018;22(5):547-54. https://doi.org/10.4196/kjpp.2018.22.5.547
Toden S, Theiss AL, Wang X, Goel A. Essential turmeric oils enhance anti-inflammatory efficacy of curcumin in dextran sulfate sodium-induced colitis. Sci Rep. 2017;7:814. https://doi.org/10.1038/s41598-017-00812-6
Amjadi MA, Mojab F, Kamranpour SB. The effect of peppermint oil on symptomatic treatment of pruritus in pregnant women. Iran J Pharm Res. 2012;11(4):1073-7.
Evangelista MT, Abad-Casintahan F, Lopez-Villafuerte L. The effect of topical virgin coconut oil on SCORAD index, transepidermal water loss, and skin capacitance in mild to moderate pediatric atopic dermatitis: a randomized, double-blind, clinical trial. Int J Dermatol. 2014;53(1):100-8. https://doi.org/10.1111/ijd.12339
Intahphuak S, Khonsung P, Panthong A. Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil. Pharm Biol. 2010;48(2):151-7. https://doi.org/10.3109/13880200903062614
Seo YM, Jeong SH. Effects of blending oil of lavender and thyme on oxidative stress, immunity, and skin condition in atopic dermatitis induced mice. J Korean Acad Nurs. 2015;45(3):367-77. https://doi.org/10.4040/jkan.2015.45.3.367
Panahi Y, Akhavan A, Sahebkar A, Hosseini SM, Taghizadeh M, Akbari H, et al. Investigation of the effectiveness of Syzygium aromaticum, Lavandula angustifolia and Geranium robertianum essential oils in the treatment of acute external otitis: a comparative trial with ciprofloxacin. J Microbiol Immunol Infect. 2014;47(3):211-6. https://doi.org/10.1016/j.jmii.2012.10.002
Vakilian K, Atarha M, Bekhradi R, Chaman R. Healing advantages of lavender essential oil during episiotomy recovery: a clinical trial. Complement Ther Clin Pract. 2011;17(1):50-3. https://doi.org/10.1016/j.ctcp.2010.05.006
Dosoky N, Setzer W. Chemical composition and biological activities of essential oils of Curcuma species. Nutrients. 2018;10(9):1196. https://doi.org/10.3390/nu10091196
Kumar A, Agarwal K, Singh M, Saxena A, Yadav P, Maurya AK, et al. Essential oil from waste leaves of Curcuma longa L. alleviates skin inflammation. Inflammopharmacology. 2018;26(5):1245-55. https://doi.org/10.1007/s10787-018-0447-3
Kamatou GP, Vermaak I, Viljoen AM, Lawrence BM. Menthol: a simple monoterpene with remarkable biological properties. Phytochemistry. 2013;96:15-25. https://doi.org/10.1016/j.phytochem.2013.08.005
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