Parathyroid carcinoma: review of a problematic case

  • Rizky I. Putri
  • Benyamin Makes
Keywords: Diagnosis, invasion, parathyroid carcinoma, primary hyperparathyroidism
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Abstract

Parathyroid carcinoma (PTCA) is a rare neoplasm that accounts for less than 1% of primary hyperparathyroidism cases. Several clinical and biochemical features can directing to PTCA, but accurate pre and intraoperative diagnosis are still difficult. This study presents a case of PTCA that diagnosed postoperatively with a discussion of microscopic feature. The surgical exploration revealed an enlarged parathyroid mass which invade recurrent laryngeal nerve and right thyroid gland. Histologic features showed tumor nodules separated by thick fibrous band with capsular invasion and local infiltration to adjacent tissues. The final diagnosis of PTCA was made based on clinical feature and specimens examination. (Med J Indones. 2012;21:170-4)

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References

  1. DeLellis RA. Parathyroid carcinoma: an overview. Adv Anat Pathol. 2005;12:53-61.

  2. Kulkarni PS, Parikh PM. The carcinoma of parathyroid gland. Indian J Cancer. 2004;41:51-9.

  3. Rodgers SE, Perrier ND. Parathyroid carcinoma. Curr Opin Oncol. 2006;18:16-22.

  4. Koea JB, Shaw JHF. Parathyroid cancer: biology and management. Surg Oncol. 1999;8:155-65.

  5. Clayman GL, Gonzalez HE, El-Naggar A, Sellin RV. Parathyroid carcinoma: evaluation and interdisciplinary management. Cancer. 2004;100:900-5.

  6. Shane E. Clinical review 122: parathyroid carcinoma. J Clin Endocrinol Metab. 2001;86:485-93.

  7. Lee YS, Hong SW, Jeong JJ, Nam KH, Chung WY, Chang HS, et al. Parathyroid carcinoma: a 16-year experience in a single institution. Endocr J. 2010;57:493-7.

  8. Cheah WK, Rauff A, Lee KO, Tan W. Parathyroid carcinoma: a case series. Ann Acad Med Singapore. 2005;34:443-6.

  9. Kameyama K, DeLellis RA, Lloyd RV, Kakudo K, Takami HE. Parathyroid carcinomas: can clinical outcomes for parathyroid carcinomas be determined by histologic evaluation alone? Endocr Pathol. 2002;13:135-9.

  10. Marcocci C, Cetani F, Rubin MR, Silverberg SJ, Pinchera A, Bilezikian JP. Review: parathyroid carcinoma. J Bone Miner Res. 2008;23:1869-80.

  11. Carlson D. Parathyroid pathology: hyperparathyroidism and parathyroid tumors. Arch Pathol Lab Med. 2010;134:1639-44.

  12. Kameyama K, Takami H. Proposal for the histological classification of parathyroid carcinoma. Endocr Pathol. 2005;16:49-52.

  13. Busaidy NL, Jimenez C, Habra MA, Schultz PN, El-Naggar AK, Clayman GL, et al. Parathyroid carcinoma: a 22-year experience. Head Neck. 2004;26:716-26.

  14. Thompson SD, Prichard AJN. The management of parathyroid carcinoma. Curr Opin Otolaryngol Head Neck Surg. 2004;12:93-7.

  15. Dey A, Agarwal D, Jain D, Malik VK. A rare case of hypercalcaemia due to parathyroid carcinoma. The Ganga Ram Journal. 2011;1:23-5.

  16. Westra WH, Pritchett DD, Udelsman R. Intraoperative confirmation of parathyroid tissue during parathyroid exploration: a retrospective evaluation of the frozen section. Am J Surg Pathol. 1998;22:538-44.

  17. Grimelius L, Johansson H. Pathology of parathyroid tumors. Semin Surg Oncol. 1997;13:142-54.

  18. DeLellis RA. Challenging lesions in the differential diagnosis of endocrine tumors: parathyroid carcinoma. Endocr Pathol. 2008;19:221-5.

  19. Khanafshar E, Zante A. Parathyroid carcinoma: problems in diagnosis. Pathol Case Rev. 2011;16:158-61.

  20. Rosai J, Ackerman LV. Parathyroid glands. In: Rosai J, Ackerman LV, editors. Surgical pathology. New York: Elsevier; 2011. p. 565-84.

Published
2012-08-01
How to Cite
1.
Putri RI, Makes B. Parathyroid carcinoma: review of a problematic case. Med J Indones [Internet]. 2012Aug.1 [cited 2024Jul.22];21(3):170-4. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/496
Section
Case Report/Series