Langerhans cell histiocytosis in cervical node in an adult female - a case report
A case of Langerhans Cell Histiocytosis (LCH) in a 58 year old woman who presented with bilateral cervical adenopathy without any other complaints is reported. Clinical examination did not reveal any other positive finding except the adenopathy. Histopathological examination confirmed the node to be Langerhans cell histiocytosis. In conclusion, LCH is a rare disease with varied clinical presentation, including cervical adenopathy. Diagnosis should be confirmed by histopathological examination of biopsy specimen. Observation may be an effective management strategy in cases of adult LCH with cervical adenopathy as the only symptom, due to its possible spontaneous regression. (Med J Indones. 2013;22:114-6)
Pritchard J, Malone M. Histiocyte disorders. In: Peckham M, Pinedo H, Veronesi U, editors. Oxford textbook of oncology.2nd edition. Oxford: Oxford University Press; 2001.p.2457-75.
Broadvent V, Pritchard J. Histiocytosis X-current controversies. Arch Dis Child. 1985;60(7):605-7.
Laman JD, Leenen PJ, Annels NE, Hogendoorn PC, Egeler RM. Langerhans-cell histiocytosis 'insight into DC biology'. Trends Immunol. 2003;24(4):190-6.
Jaffe R. The diagnostic histopathology of Langerhans cell histiocytosis. In: Weitzman S, Egeler R M, editors. Histiocytic disorders of children and adults. United Kingdom: Cambridge University Press; 2005.p.14-39.
Elsheikh T, Silverman JF, Wakely PE Jr, Holbrook CT, Joshi VV. Fine needle aspiration cytology of Langerhans cell histiocytosis (eosinophilic granuloma) of bone in children. Diagn Cytopathol. 1991;7(3):261-6.
Baumgartner I, von Hochstetter A, Baumert B, Luetolf U, Follath F. Langerhans-cell histiocytosis in adults. Medical & Pediatric Oncology. 1997;28:9-14.
Kaltsas GA, Powles TB, Evanson J, et al. Hypothalamopituitary abnormalities in adult patients with Langerhans cell histiocytosis: clinical, endocrinological, and radiological features and response to treatment. J Clin Endocrinol Metab. 2000;85(4):1370-6.
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