Effectiveness of permethrin standard and modified methods in scabies treatment

Saleha Sungkar, Triana Agustin, Sri L. Menaldi, Ahmad Fuady, Herqutanto Herqutanto, Hansen Angkasa, Victor Santawi, Hirzi Zulkarnain



DOI: https://doi.org/10.13181/mji.v23i2.594

Abstract


Background: Permethrin is the drug of choice for scabies with side effects such as erythema, pain, itching and prickling sensation. Whole-body (standard) topical application of permethrin causes discomfort; thus, modified application of permethrin to the lesion only, followed with baths twice daily using soap was proposed. The objective of the study is to know the effectiveness of standard against lesion-only application of permethrin in scabies treatment.

Methods: An experimental study was conducted in pesantren in East Jakarta and data was collected in May-July 2012. Diagnosis of scabies was made through anamnesis and skin examination. Subjects positive for scabies were divided into three groups: one standard method group (whole-body topical application) and two modified groups (lesion-only application followed by the use of regular soap and antiseptic soap group). The three groups were evaluated weekly for three consecutive weeks. Data was processed using SPSS 20 and analyzed by Kruskal-Wallis test.

Results: Total of 94 subjects was scabies positive (prevalence 50%) but only 69 subjects were randomly picked to be analyzed. The cure rate at the end of week III of the standard method group was 95.7%, modified treatment followed by the use of regular soap was 91.3%, and modified treatment followed by the use of antiseptic soap was 78.3% (p = 0.163). The recurrence rate of standard treatment was 8.7%,  modified treatment followed by the use of regular soap was 13% and modified treatment followed by the use of antiseptic soap was 26.1% (p = 0.250).

Conclusion: The standard scabies treatment was as effective as the modified scabies treatment.


Keywords


bath; permethrin; scabies; soap

Full Text:

PDF

References


  1. Parsons J. Peran pesantren dan cita-cita santri putri: sebuah perbandingan di antara dua pondok pesantren di Jawa [thesis]. Mount Pleasant (MI): Universitas Muhammadiyah Malang; 2002. Indonesian.
  2. Muzakir. Faktor yang berhubungan dengan penyakit skabies di pesantren di Kabupaten Aceh Besar tahun 2007 [thesis]. Mount Pleasant (MI): Universitas Sumatera Utara; 2008. Indonesian.
  3. Hilmy F. Prevalensi penyakit skabies dan hubungannya dengan karakteristik santri pesantren X Jakarta Timur [skripsi]. Mount Pleasant (MI): Universitas Indonesia; 2010. Indonesian.
  4. Meinking LT. Safety of permethrin vs lindane for the treatment of scabies. Arch Dermatol. 1996;132(8):959-62. http://dx.doi.org/10.1001/archderm.132.8.959
  5. Sungkar S. Scabies. Journal of the Indonesian Medical Association 1997;47(1):33-42. Indonesian.
  6. Usha V, Gopalakrishnan Nair TV. A comparative study of oral ivermectin and topical permethrin cream in the treatment of scabies. J Am Acad Dermatol. 2000;42(2 Pt 1):236-40. http://dx.doi.org/10.1016/S0190-9622(00)90131-2
  7. Chhaiya SB, Patel VJ, Dave JN, Mehta DS, Shah HA. Comparative efficacy and safety of topical permethrin, topical ivermectin, and oral ivermectin in patients of uncomplicated scabies. Indian J Dermatol Venereol Leprol. 2012;78(5):605-10. http://dx.doi.org/10.4103/0378-6323.100571
  8. Yonkosky D, Ladia L, Gackenheimer L, Schultz MW. Scabies in nursing homes: an eradication program with permethrin 5% cream. J Am Acad Dermatol. 1990;23(6 Pt 1):1133-6. http://dx.doi.org/10.1016/0190-9622(90)70346-J
  9. Georgia Department of Public Health. Scabies Handbook. Georgia: Georgia Department of Public Health; 2011.
  10. Makigami K, Ohtaki N, Ishii N, Tamashiro T, Yoshida S, Yasumura S. Risk factors for recurrence of scabies: a retrospective study of scabies patients in a long-term care hospital. J Dermatol. 2011;38(9):874-9. http://dx.doi.org/10.1111/j.1346-8138.2011.01199.x
  11. Mollison LC, Lo STH, Marking G. HTLV-1 and scabies in Australian Aborigines. Lancet. 1993;341(8855):1281-2. http://dx.doi.org/10.1016/0140-6736(93)91186-P
  12. Hengge UR, Currie BJ, Jäger G, Lupi O, Schwartz RA. Review article. Scabies: a ubiquitous neglected skin disease. Lancet Infect Dis. 2006;6(12):769-79. http://dx.doi.org/10.1016/S1473-3099(06)70654-5
  13. Sungkar S. Skabies. Jakarta: Yayasan Penerbitan Ikatan Dokter Indonesia; 1995. Indonesian.
  14. Elston DM. Controversies concerning the treatment of lice and scabies. J Am Acad Dermatol. 2002;46(5):794-6. http://dx.doi.org/10.1067/mjd.2002.121027





Copyright (c) 2014 Saleha Sungkar, Triana Agustin, Sri L. Menaldi, Ahmad Fuady, Herqutanto Herqutanto, Hansen Angkasa, Victor Santawi, Hirzi Zulkarnain

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All articles and issues in Medical Journal of Indonesia have unique DOI number registered in Crossref.
 
Romeo