Characteristics of patients with rheumatic heart disease in a national referral hospital in Indonesia

Estu Rudiktyo; Annemieke Wind; Pieter Doevendans; Bambang Budi Siswanto; Maarten-Jan Cramer; Amiliana Mardiani Soesanto

doi:10.13181/mji.oa.226150

Authors

Estu Rudiktyo Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia https://orcid.org/0000-0002-9230-1630
Annemieke Wind Department of Cardiology, Diakonessen Hospital, Utrecht, The Netherlands; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
Pieter Doevendans Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands; Central Military Hospital Utrecht, Utrecht, The Netherlands; Netherlands Heart Institute Utrecht, Utrecht, The Netherlands https://orcid.org/0000-0002-6257-7169
Bambang Budi Siswanto Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia - National Cardiovascular Center Harapan Kita, Jakarta, Indonesia https://orcid.org/0000-0003-3998-1590
Maarten-Jan Cramer Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands https://orcid.org/0000-0002-6041-6759
Amiliana Mardiani Soesanto Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia

DOI:

https://doi.org/10.13181/mji.oa.226150

Keywords:

echocardiography, pathology, rheumatic heart disease, right ventricular dysfunction

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Abstract

BACKGROUND Rheumatic heart disease (RHD) is one of the most common cardiovascular problems in Indonesia. Comprehensive data regarding patient characteristics are critical in planning optimal treatment strategies to relieve the burden of RHD. This study aimed to describe the clinical and echocardiographic characteristics of patients across several types of valvular lesions in RHD in the Indonesian population.

METHODS This retrospective study was performed between January 2016 and June 2019 at the National Cardiovascular Center Harapan Kita, Jakarta, Indonesia. The study population comprised all patients with significant valve disease aged ≥18 years. Patient characteristics and echocardiographic parameters were collected retrospectively from medical records and hospital information systems. Patients were classified into several groups based on etiologies of valve disease.

RESULTS Of 5,482 patients with significant valve lesions, 2,333 (42.6%) were RHD patients. They were predominantly female (64.1%) and younger (mean [standard deviation] age 42.61 [12.01] years). Atrial fibrillation (AF) was the most frequent rhythm disorder observed in RHD (65.4%). Isolated mitral stenosis was the most common valve lesion in RHD patients (46.5%). Most patients with RHD had preserved left ventricular (LV) ejection fraction. Half of the patients with mitral stenosis had reduced right ventricular (RV) contractility (tricuspid annular plane systolic excursion <17 mm).

CONCLUSIONS Isolated mitral stenosis was the most observed condition of valve lesions in RHD. Characteristics of RHD patients in this study were predominantly female, younger age, had preserved LV function, reduced RV function, and high prevalence of AF.

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