Predictor of recurrent exacerbations in pediatric asthma

  • Ly Cong Tran Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam
  • Hung Viet Phan Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam
  • Thu Vo-Pham-Minh Department of Internal Medicine, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam
  • Nghia Quang Bui Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam
  • Chuong Nguyen-Dinh-Nguyen Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam
  • Nguyen Thi Nguyen Thao Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam
  • Ai Uyen Nguyen Huynh Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam
  • Nhu Thi Huynh Tran Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam
  • Phuong Minh Nguyen Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho City, Vietnam
DOI: https://doi.org/10.13181/mji.oa.247309
Keywords: asthma, children, exacerbation, prognosis, spirometry
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Abstract

BACKGROUND Asthma imposes a heavy morbidity burden during childhood. Severe persistent asthma significantly increases patients’ risk of exacerbations, hospital admissions, and mortality and often substantially impairs their quality of life. This study aimed to identify high-risk patients for exacerbation recurrence using spirometric parameters.

METHODS A prospective cohort study involving patients with asthma aged 6–15 years was conducted at the principal children’s hospital in Mekong Delta, Vietnam, from June 2020 to June 2022. Demographic, clinical, and lung function characteristics of the patients were collected. Spirometry measurement parameters were utilized as predictive factors for the short-term asthma exacerbation recurrence.

RESULTS Among all patients (mean age of 9.5 years old), 10.4% experienced recurrent exacerbations. FEV1, FVC, FEV1/FVC, FEF25–75, FEF25–75/FVC, and PEF, gradually decreased with increasing exacerbation severity (p<0.01). All patients showed a positive bronchodilator responsiveness (BDR), with a mean value of 16.85 (3.00)%, which was significantly different between the severe and non-severe asthma groups (20.53 [2.83] versus 16.00 [2.35], p<0.001). After adjusting in multivariable logistic regression, a BDR ≥20% was identified as the sole independent factor associated with an increased risk of asthma exacerbation recurrence (aOR 6.95, 95% CI 1.08–44.75, p = 0.041).

CONCLUSIONS A high BDR can serve as a predictor of acute asthma exacerbation recurrence.

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Published
2024-04-05
How to Cite
1.
Tran LC, Phan HV, Vo-Pham-Minh T, Bui NQ, Nguyen-Dinh-Nguyen C, Nguyen Thao NT, Nguyen Huynh AU, Tran NTH, Nguyen PM. Predictor of recurrent exacerbations in pediatric asthma. Med J Indones [Internet]. 2024Apr.5 [cited 2024May2];1(1). Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/7309
Issue
Online First
Section
Clinical Research

Copyright (c) 2024 Ly Cong Tran, Hung Viet Phan, Thu Vo-Pham-Minh, Nghia Quang Bui, Chuong Nguyen-Dinh-Nguyen, Nguyen Thi Nguyen Thao, Ai Uyen Nguyen Huynh, Nhu Thi Huynh Tran, Phuong Minh Nguyen

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