Impact of ablation dose in the treatment of thyroid cancer with I-131

  • Cholid Badri Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta.
  • Dharma Gayo Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta.
  • Suryo Seto Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta.
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Abstract

Tujuan : Untuk menilai keberhasilan terapi ablasi dengan lodium-131 menggunakan dosis yang berbeda pada penderita karsinoma tiroid berdiferensiasi baik yang telah menjalani operasi tiroidektomi total atau hampir total. Cara : Penelitian retrospektif terhadap 42 pasien yang dirawat di Rumah Sakit Dr Cipto Mangunkusumo antara tahun 1993 - 1996. Diberikan ablasi dengan dosis 80 mCi dan JOO mCi pada kelompok pasien yang masing-masing terdiri dari 21 penderita. Sebelum ablasi, dilakukan pemeriksaan dengan sidik tiroid dan seminggu sesudah ablasi dilakukan sidik seluruh tubuh. Penilaia11 keberhasila11 ablasi dilakukan 3 bulan setelah ablasi dengan pemeriksaan sidik seluruh tubuh dengan 5 mCi 1-131. Hasil : Keberhasilan terapi ablasi denga11 dosis 100 mCi berbeda bermakna dengan dosis 80 mCi, yaitu sebesar 85,7 % dibandi11gkan dengan 57 % (p = 0,04). Efek samping akut dijumpai sebanyak 19 % pada pemberian dosis 100 mCi dan 4,8 % pada dosis 80 mCi. Sidik tiroid yang dilakukan I minggu setelah ablasi menunjukkan metastasis sebanyak 19 % denga11 pemberian dosis JOO 111Ci dan 4,8 % dengan dosis 80 mCi. Kesimpulan : Ablasi dengan dosis 100 mCi 1-131 memperlihatkan hasil yang lebih baik dibandingkan dosis 80 mCi dan tidak meningkatkan efek samping pengobatan secara bermakna. Di samping itu ablasi dengan dosis JOO mCi kemungkinan dapat lebih ba11yak menemukan adanya metastasis jauh dibandingkan dengan dosis 80 mCi. . Abstract Purpose : To evaluate the efficacy of ablation therapy using Iodine- ] 31 with two different doses on patients with well-differentiated thyroid cancer who had been operated upon with total or near-total thyroidectomy. Methods: A retrospective study was conducted on 42 patients admitted at the Dr. Cipto Mangunkusumo Hospital, Jakarta between 1993-1996. Thyroid ablation was performed with 80 mCi and 100 mCi on each group consisting of 21 patients respectively. Thyroid scan was performed before ablative procedure, and followed by whole body scanning one week after the ablation.. Efficacy of the treatment was evaluated three months after ablation therapy using whole body scanning with 5 mCi of 1-131. Results : The efficacy of ablation therapy with a dose of 100 mCi was 85,7 %, significantly better than 57. % with a dose of 80 mCi dose (p=0,04 ) . Acute side effects were seen in 4,8 % with a dose of JOO mCi and 19 % of patients with a dose 80 mCi. Whole body scanning peiformed one week after ablation therapy revealed 19% distant metastases with the dose of 100 mCi as compared to 4,8 % with the dose of 80 mCi. Conclusions : Thyroid ablation with a dose of 100 mCi 1-131 showed a better result as compared to 80 mCi dose, as side effects of the treatment were not significantly different. Moreover, ablation therapy with a dose of 100 mCi probably could detect more distant metastases as compared to 80 mCi dose. Keywords : Thyroid cancer, radioiodine treatment, ablation dose
Published
1998-07-01
How to Cite
1.
Badri C, Gayo D, Seto S. Impact of ablation dose in the treatment of thyroid cancer with I-131. Med J Indones [Internet]. 1998Jul.1 [cited 2021Dec.3];7(3):169-74. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/775
Section
Medical Journal of Indonesia