High preterm birth at Cipto Mangunkusumo Hospital as a national referral hospital in Indonesia

Authors

  • Ali Sungkar Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Adly N.A. Fattah Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Raymond Surya Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Budi I. Santoso Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta
  • Ivica Zalud Department of Obstetrics and Gynecology and Women's Health, John A Burns School of Medicine, University of Hawaii, Hawaii

DOI:

https://doi.org/10.13181/mji.v26i3.1454

Keywords:

outcome, preterm birth, prevalence, risk factor

Abstract

Background: Preterm birth is the leading direct that causes neonatal death. Indonesia was listed as one of the countries with the greatest number of preterm birth in 2010. This study aims to identify the prevalence and the potential risk factors of preterm birth among women underwent delivery in Cipto Mangunkusumo Hospital, an Indonesian national reference hospital.

Methods: This retrospective cohort study involved 2,612 women who delivered between January and December 2013. Any clinical data which related to the potential risk factors and outcomes were recorded. The data were managed using chi-square for bivariate analysis and t-test or Mann-Whitney for numerical data followed by multiple logistic regression for multivariate analysis in SPSS version 20.0.

Results: Preterm birth affected 1,020 of 2,616 pregnancies (38.5%). Non-booked patients increased nearly twice risk for preterm delivery (OR 1.89, 95% CI 1.37-2.61). While women with singleton pregnancy (OR 0.17, 95% CI 0.12-0.25), head presentation (OR 0.75, 95% CI 0.63-0.89), and regular ANC (OR 0.67, 95% CI 0.54-0.84) had lower risk for preterm birth. Apgar score, birthweight, and mode of delivery were significantly different between the pre-term group and the full-term group.

Conclusion: Prevalence of preterm birth in Cipto Mangunkusumo Hospital was approximately 2.5 times higher compared to the national number. Several factors reducing preterm birth rate include singleton pregnancy, head presentation, and regular ANC.

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References

Lawn JE, Gravett MG, Nunes TM, Rubens CE, Stanton C, GAPPS Review Group. Global report on preterm birth and stillbirth (1 of 7): definitions, description of the burden and opportunities to improve data. BMC Pregnancy Childbirth. 2010;10 Suppl 1:S1. https://doi.org/10.1186/1471-2393-10-S1-S1

Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371(9606):75-84. https://doi.org/10.1016/S0140-6736(08)60074-4

Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller A-B, Narwal R, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012;379(9832):2162-72. https://doi.org/10.1016/S0140-6736(12)60820-4

Warren JE, Silver RM. Genetics of the Cervix in Relation to Preterm Birth. Semin Perinatol. 2009;33(5):308-11. https://doi.org/10.1053/j.semperi.2009.06.003

Murphy DJ. Epidemiology and environmental factors in preterm labour. Best Pract Res Clin Obstet Gynaecol. 2007;21(5):773-89. https://doi.org/10.1016/j.bpobgyn.2007.03.001

Lo CC, Hsu JJ, Hsieh CC, Hsieh TT, Hung T-H. Risk Factors for Spontaneous Preterm Delivery Before 34 Weeks of Gestation Among Taiwanese Women. Taiwan J Obstet Gynecol. 2007;46(4):389-94. https://doi.org/10.1016/S1028-4559(08)60008-X

Hofer N, Kothari R, Morris N, Müller W, Resch B. The fetal inflammatory response syndrome is a risk factor for morbidity in preterm neonates. Am J Obstet Gynecol. 2013 Dec;209(6):542.e1-542.e11. https://doi.org/10.1016/j.ajog.2013.08.030

Olgun NS, Reznik SE. The matrix metalloproteases and endothelin-1 in infection-associated preterm birth. Obstet Gynecol Int. 2010;2010(11):1-8. http://dx.doi.org/10.1155/2010/657039

Wen SW, Smith G, Yang Q, Walker M. Epidemiology of preterm birth and neonatal outcome. Semin Fetal Neonatal Med. 2004;9(6):429-35. https://doi.org/10.1016/j.siny.2004.04.002

UNICEF [Internet]. Maternal, Newborn & Child Survival. [update 2008 ; cited 2017]. Availabe from : www.unicef.org/eapro/Indonesia_Eng.pdf. p. 1-4.

Zachariassen G, Fenger-Gron J. Preterm dietary study: meal frequency, regurgitation and the surprisingly high use of laxatives among formula-fed infants following discharge. Acta Paediatr. 2014 Mar;103(3):e116-22. DOI: 10.1111/apa.12524

Erez O, Mayer A, Shoham-Vardi I, Dukler D, Mazor M. Primiparity, assisted reproduction, and preterm birth in twin pregnancies: a population based study. Arch Gynecol Obstet. 2007 Oct 31;277(4):311-7. DOI 10.1007/s00404-007-0492-4

Chen CP, Wang KG, Yang YC, See LC. Risk factors for preterm birth in an upper middle class Chinese population. Eur J Obstet Gynecol. 1996 Dec;70(1):53-9. DOI: 10.1016/S0301-2115(96)02555-9

Nguyen N, Savitz DA, Thorp JM. Risk factors for preterm birth in Vietnam. Int J Gynecol Obstet. 2004;86(1):70-8. https://doi.org/10.1016/j.ijgo.2004.04.003

Newburn-Cook CV, Onyskiw JE. Is older maternal age a risk factor for preterm birth and fetal growth restriction? A systematic review. Health Care Women Int. 2005;26(9):852-75. https://doi.org/10.1080/07399330500230912

Di Renzo GC, Giardina I, Rosati A, Clerici G, Torricelli M, Petraglia F, et al. Maternal risk factors for preterm birth: a country-based population analysis. Eur J Obstet Gynecol Reprod Biol. 2011 Dec;159(2):342-6. https://doi.org/10.1016/j.ejogrb.2011.09.024

Bastek JA, Sammel MD, Srinivas SK, McShea MA, Foreman MN, Elovitz MA, et al. Clinical prediction rules for preterm birth in patients presenting with preterm labor. Obstet Gynecol. 2012;119(6):1119-28. https://doi.org/10.1097/AOG.0b013e31825503e5

Nice Clinical Guidelines. Multiple pregnancy: The management of twin and triplet pregnancies in the antenatal period. RCOG; 2011.

Chandra S, Tripathi AK, Mishra S, Amzarul M, Vaish AK. Physiological changes in hematological parameters during pregnancy. Indian J Hematol Blood Transfus. 2012; 28(3):144-6. https://doi.org/10.1007/s12288-012-0175-6

Marchant T, Willey B, Katz J, Clarke S, Kariuki S, Kuile FT, et al. Neonatal Mortality Risk Associated with Preterm Birth in East Africa, Adjusted by Weight for Gestational Age: Individual Participant Level Meta-Analysis. PLoS Med. 2012;9(8):e1001292. https://doi.org/10.1371/journal.pmed.1001292

Gouyon JB, Vintejoux A, Sagot P, Burguet A, Quantin C, Ferdynus C, et al. Neonatal outcome associated with singleton birth at 34â??41 weeks of gestation. Int J Epidemiol. 2010;39(3):769-7. https://doi.org/10.1093/ije/dyq037

McCormick MC, Escobar GJ, Zheng Z, Richardson DK. Place of birth and variations in management of late preterm (“near-term”) infants. Semin Perinatol. 2006;30(1):44–7. https://doi.org/10.1053/j.semperi.2006.01.012

Published

2017-11-27

How to Cite

1.
Sungkar A, Fattah AN, Surya R, Santoso BI, Zalud I. High preterm birth at Cipto Mangunkusumo Hospital as a national referral hospital in Indonesia. Med J Indones [Internet]. 2017Nov.27 [cited 2024Nov.22];26(3):198-203. Available from: https://mji.ui.ac.id/journal/index.php/mji/article/view/1454

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Section

Clinical Research
Abstract viewed = 3098 times

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