Benefit of trehalose preincubation prior to cryopreservation

  • Jeanne A. Pawitan Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta
Keywords: editorial
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Author Biography

Jeanne A. Pawitan, Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta
SCOPUS h-index: 4


  1. Kusuma I, Hadi RS, Kiranadi B, Boediono A. Trehalose preincubation increases mesenchymal (CD271+) stem cells post cryopreservation viability. Med J Indones. 2016;25(3):129-35.

  2. Marquez-Curtis LA, Janowska-Wieczorek A, McGann LE, Elliott JAW. Mesenchymal stromal cells derived from various tissues: biological, clinical and cryopreservation aspects. Cryobiology. 2015;71:181-97.

  3. Castillo N, García-Cadenas I, Barba P, Martino R, Azqueta C, Ferrà C, et al. Post-thaw viable CD45þ cells and clonogenic efficiency are associated with better engraftment and outcomes after single cord blood transplantation in adult patients with malignant diseases. Biol Blood Marrow Transplant. 2015;21:2167-72.

  4. Francois M, Copland IB, Yuan S, Romieu-Mourez R, Waller EK, Galipeau J. Cryopreserved mesenchymal stromal cells display impaired immunosuppressive properties as a result of heat-shock response and impaired interferon-ɣ licensing. Cytotherapy. 2012;14:147-52.

  5. Moll G, Alm JJ, Davies LC, von Bahr L, Heldring N, Stenbeck-Funke L, et al. Do cryopreserved mesenchymal stromal cells display impaired immunomodulatory and therapeutic properties? Stem Cells. 2014;32(9):2430-42.

  6. Galipeau J. The mesenchymal stromal cell dilemma—does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?. Cytotherapy. 2013;15(1):2-8.

  7. Pollock K, Sumstad D, Kadidlo D, McKenna DH, Hubel A. Clinical mesenchymal stromal cell products undergo functional changes in response to freezing. Cytotherapy. 2015;17:38-45.

How to Cite
Pawitan JA. Benefit of trehalose preincubation prior to cryopreservation. Med J Indones [Internet]. 2016Oct.14 [cited 2024Jun.20];25(3):127-8. Available from: