Impact of metabolic syndrome on lower urinary tract symptoms in patients with benign prostate hyperplasia

  • Dyandra Parikesit Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, Depok, West Java, Indonesia http://orcid.org/0000-0001-5779-2713
  • Fiastuti Witjaksono Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Chaidir Arif Mochtar Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Nur Rasyid Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Agus Rizal Ardy Hariandy Hamid Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Keywords: benign prostate hyperplasia, lower urinary tract symptoms, metabolic syndrome
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Abstract

BACKGROUND Studies evaluating the relationship between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) in men with benign prostate hyperplasia (BPH) are lacking in Indonesia. This study aimed to discover the association of LUTS and MetS in men with BPH.

METHODS Subjects who underwent biopsy were recruited from Cipto Mangunkusumo Hospital, Jakarta, Indonesia from January 2014 to January 2018, but only men who had biopsy-proven BPH were included. Body mass index, waist circumference, fasting blood glucose, triglyceride, high-density lipoprotein, prostate volume (PV), and international prostate symptom score (IPSS) were collected before the biopsy. MetS criteria were based on the National Cholesterol Education Program Adult Treatment Panel III. IPSS was assessed for LUTS and consisted of irritative and obstructive symptoms and quality of life (QoL). Independent t-test or Mann–Whitney test was used to analyze numerical data.

RESULTS Of 227 men with biopsy-proven BPH, 87 (38.3%) were diagnosed with MetS. PV was similar in men with or without MetS (54.4 [20.3–100] versus 49.9 [19.5–100] cm3, p = 0.239). Men with MetS generally had more LUTS (15 [1–30] versus 11 [0–35], p = 0.005), more irritative symptoms (8 [0–20] versus 6 [0–20], p = 0.007), and lower QoL (4 [0–6] versus 3 [0–6], p = 0.018).

CONCLUSIONS BPH patients with MetS had greater LUTS, particularly irritative symptoms and QoL score.

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Published
2021-06-30
How to Cite
1.
Parikesit D, Witjaksono F, Mochtar CA, Rasyid N, Hamid ARAH. Impact of metabolic syndrome on lower urinary tract symptoms in patients with benign prostate hyperplasia. Med J Indones [Internet]. 2021Jun.30 [cited 2021Oct.26];30(2):138-42. Available from: https://mji.ui.ac.id/journal/index.php/mji/article/view/4256
Section
Clinical Research