Association between multimeric adiponectin and free leptin index with atherogenic dyslipidemia in non-diabetic obese men
Background: To analyze the role of various adiponectin and free leptin index on the occurrence of atherogenicÂ dislipidemia in non-diabetic central obese men.
Methods: This is a cross-sectional study on 120 non-diabetic central obese men that was done in Jakarta. The measuredÂ indicators were total adiponectin, high molecular weight adiponectin (HMW adiponectin), medium molecular weightÂ adiponectin (MMW adiponectin), low molecular weight adiponectin (LMW adiponectin), leptin, soluble leptinÂ receptor, triglycerides, high-density lipoprotein cholesterol (HDL cholesterol), low density lipoprotein cholesterolÂ (LDL cholesterol) and apolipoprotein B (Apo B). Atherogenic dyslipidemia was characterized by reduced level ofÂ HDL cholesterol, and high levels of triglyceride and small dense LDL (sdLDL). Ratio of LDL cholesterol and Apo BÂ were calculated to get sdLDL. Free Leptin Index (FLI) was the ratio between total leptin and soluble leptin receptorÂ (sOB-R), and median values were used as cut off to defi ne high and low values of each parameter. Cross tabulationÂ were done on categorical data. Relationships between multimeric adiponectin and free leptin index with atherogenicÂ lipids were analyzed by using Spearman analysis. Further, the interaction of all indicators with the occurence ofÂ atherogenic dyslipidemia was analyzed using binary logistic regression.
Results: A negative correlation of HMW adiponectin with atherogenic dyslipidemia (p < 0.05), whereas there were noÂ correlation between MMW adiponectin and LMW adiponectin with atherogenic dyslipidemia (p > 0.05). Free Leptin IndexÂ was associated positively with atherogenic dyslipidemia (p < 0.05). Odds Ratio (OR) of HMW adiponectin for the occurrenceÂ of atherogenic dyslipidemia was 3.62 (p < 0.05), where as OR of FLI with atherogenic dyslipidemia was 4.57 (p < 0.05).
Conclusion: HMW Adiponectin and FLI might contribute to atherogenic dyslipidemia in central obese non-diabetic males.Â (Med J Indones 2011; 20:119-24)
Keywords: HMW adiponectin, LMW adiponectin, MMW adiponectin, total adiponectin
Copyright (c) 2011 Candra Ninghayu, Andi Wijaya, Suryani Asâad
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