Serum vascular endothelial growth factor as a predictor of clinical outcomes in anterior circulation ischemic stroke

  • Vivien Puspitasari Department of Neurology, Faculty of Medicine Pelita Harapan University, Jakarta
  • Syarifuddin Wahid Department of Anatomical Pathology, Faculty of Medicine Hasanuddin University, Makasar
  • Amiruddin Aliah Department of Neurology, Faculty of Medicine Hasanuddin University, Makasar
  • Budhianto Suhadi Department of Clinical Pathology, Faculty of Medicine Pelita Harapan University, Jakarta
  • Cahyono Kaelan Department of Neurology, Faculty of Medicine Hasanuddin University, Makasar
  • Suryani As'ad Department of Nutrition, Faculty of Medicine Hasanuddin University, Makasar
  • Ilhamjaya Patellongi Department of Physiology, Faculty of Medicine, Hasanuddin University, Makasar
  • Jan S. Purba Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta
  • Eka J. Wahjoepramono Department of Neurosurgery, Faculty of Medicine, Pelita Harapan University, Jakarta
Keywords: angiogenesis, clinical outcomes, ischemic stroke, VEGF
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Abstract

Background: Inflammatory response in the acute phase of ischemic stroke will trigger the process of neuroplasticity and determine the clinical outcomes. Angiogenesis and neurogenesis are induced by expression of vascular endothelial growth factor (VEGF) in the acute phase of stroke. The purpose of this study was to determine the association between VEGF serum level in acute phase of stroke with the clinical outcomes.

Methods: This longitudinal cohort study was conducted on 64 patients suffering from first-attack of anterior circulation blockage as evidenced by cephalic diffusion-weighted magnetic resonance imaging (DWI). VEGF serum level was measured at 72 hours and 7 days after stroke and the clinical outcomes were assessed on day 30 post-stroke using the National Institutes of Health Stroke Scale (NIHSS).

Results: VEGF level at hour-72 and on day-7 were 5.84 ± 0.736 ng/mL and 5.797 ± 0.96 ng/mL, respectively (p > 0.05). High VEGF levels at hour-72 can be used to predict poor clinical outcome 30 days after stroke (OR = 6.5; 95% CI = 1.15-36.61; p = 0.034). Subjects who have increasing levels of VEGF on day-7 compared to hour-72 tend to have better clinical outcomes on day-30. (NIHSS score = 1.33 ± 1.22 vs 3 ± 3.78; p = 0.232).

Conclusion: VEGF levels in the acute phase of ischemic stroke reflect the degree of brain damage, the dynamic of the increase in VEGF levels after a stroke was associated with better clinical outcomes.

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Author Biographies

Vivien Puspitasari, Department of Neurology, Faculty of Medicine Pelita Harapan University, Jakarta
Neurology Departement Faculty of Medicine, Pelita Harapan University
Syarifuddin Wahid, Department of Anatomical Pathology, Faculty of Medicine Hasanuddin University, Makasar
Anatomical Pathology Departement Faculty of Medicine, Hasanuddin University
Amiruddin Aliah, Department of Neurology, Faculty of Medicine Hasanuddin University, Makasar
Departement of Neurology  Faculty of Medicine, Hasanuddin University
Budhianto Suhadi, Department of Clinical Pathology, Faculty of Medicine Pelita Harapan University, Jakarta
Departement of Clinical Pathology,  Faculty of Medicine, Pelita Harapan University
Cahyono Kaelan, Department of Neurology, Faculty of Medicine Hasanuddin University, Makasar
Departement of Neurology, Faculty of Medicine, Hasanuddin University
Suryani As'ad, Department of Nutrition, Faculty of Medicine Hasanuddin University, Makasar
Faculty of Medicine, Hasanuddin University
Ilhamjaya Patellongi, Department of Physiology, Faculty of Medicine, Hasanuddin University, Makasar
Faculty of Medicine, Hasanuddin University
Jan S. Purba, Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta
Departement of Neurology, Faculty of Medicine,Indonesia University
Eka J. Wahjoepramono, Department of Neurosurgery, Faculty of Medicine, Pelita Harapan University, Jakarta
Departement of Neurosurgery,  Faculty of Medicine, Pelita Harapan University

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Published
2015-06-25
How to Cite
1.
Puspitasari V, Wahid S, Aliah A, Suhadi B, Kaelan C, As’ad S, Patellongi I, Purba JS, Wahjoepramono EJ. Serum vascular endothelial growth factor as a predictor of clinical outcomes in anterior circulation ischemic stroke. Med J Indones [Internet]. 2015Jun.25 [cited 2019Aug.23];24(2):109-14. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/1196
Section
Clinical Research