Mechanism of normal menstruation and abnormality associated with menorrhagia
Normal menstruation involves endometrial tissue breakdown and bleeding, followed by hemostasis and repair. Abnormality of thisÂ process at any stage may result in changes in the quantity of menstrual blood loss. When menstrual blood loss is greater than 80 ml, itÂ is called menorrhagia. This review discuss the mechanism of normal menstruation, and factors associated with menorrhagia. ThoseÂ factors are the endometrial bleeding associated factor (ebaf), the role of various cells (migratory leucocytes, macrophages, and mastÂ cells), the role of various substances (lysosomal enzymes, prostaglandins, endothelins, growth factors and its receptors), impairmentÂ of fibrinolysis and hemostatic proces, and changes in endometrial blood flow. (Med J Indones 2001; 10: 121-6)
Keywords : ebaf, prostaglandin, endothelin, fibrinolysis
Copyright (c) 2001 Jeanne A. Pawitan
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