Prediction of pregnancy success rate through in vitro fertilization based on maternal age

  • Soegiharto Soebijanto
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Abstract

Aim To evaluate the correlation between the success of pregnancy through in vitro fertilization and maternal age. Methods Assessment of pregnancy was performed in eight in vitro fertilization centers in Indonesia: Harapan Kita Pediatric and Obstetric Hospital from 1997 to 2001, and seven in vitro fertilization centers in Indonesia. Follicular induction was performed through the long protocol, short protocol and natural cycle. Insemination was performed through ICSI (intra cytoplasmic sperm injection) on petri dish. Spermatozoa were obtained through masturbation, testicular biopsy and epididimical biopsy. A successful pregnancy was indicated chemically, with the presence of fetal heart beat and the birth of a baby (take home baby). Results There was a 34% pregnancy rate for the age group below 30 years, 33.75% for those between 31 and 35 years olds, and 26% for the age group 36 to 40 years old, and 8% for the age group above 40 years. Conclusion The higher the maternal age, the lower pregnancy rate. In other words, the higher the maternal age, the higher the rate of miscarriage. (Med J Indones 2009; 18: 244-8)

Keywords: pregnancy, in vitro fertilization

References

  1. Piette C, de Mouzon J, Bachelot A, Spira A. In-vitro

  2. fertilization: infl uence of womenâs age on pregnancy rates.

  3. Hum Reprod. 1990; 5:56â9

  4. Tucker MJ, Morton PC, Wright G, Ingargiola PE,

  5. Jones AE, Sweitzer CL. Factors affecting success with

  6. intracytoplasmic sperm injection. Reprod Fertil Dev. 1995;

  7. :229â36

  8. Ashkenazi J, Orvieto R, Gold-Deutch R, Feldberg D, Dicker

  9. D, Voliovitch I, Ben Rafael Z. The impact of womanâs age

  10. and sperm parameters on fertilization rates in IVF cycles.

  11. Eur J Obstet Gynecol Reprod Biol. 1996; 66:155â9

  12. Hull MG, Fleming CF, Hughes AO, McDermott A. The

  13. age-related decline in female fecundity: a quantitative

  14. controlled study of implanting capacity and survival of

  15. individual embryos after in vitro fertilization. Fertil Steril.

  16. ; 65:783â90

  17. Widra EA, Gindoff PR, Smotrich DB, Stillman RJ.

  18. Achieving multiple-order embryo transfer identifi es women

  19. over 40 years of age with improved in vitro fertilization

  20. outcome. Fertil Steril. 1996; 65:103â8

  21. Templeton A, Morris JK, Parslow W. Factors that affect

  22. outcome of in-vitro fertilisation treatment. Lancet. 1996;

  23. :1402â06

  24. Legro RS, Shackleford DP, Moessner JM, Gnatuk CL,

  25. Dodson WC. ART in women 40 and over. Is the cost worth

  26. it? J Reprod Med. 1997; 42:76â82

  27. te Velde ER, Pearson PL. The variability of female reproductive

  28. ageing. Hum Reprod Update. 2002; 8:141â54

  29. van Hooff MH, Alberda AT, Huisman GJ, Zeilmaker

  30. GH, Leerentveld RA. Doubling the human menopausal

  31. gonadotrophin dose in the course of an in-vitro fertilization

  32. treatment cycle in low responders: a randomized study.

  33. Hum Reprod. 1993; 8:369â73

  34. Tarlatzis BC, Zepiridis L, Grimbizis G, Bontis J. Clinical

  35. management of low ovarian response to stimulation for IVF:

  36. a systematic review. Hum Reprod Update. 2003; 9:61â76

  37. Faber BM, Mayer J, Cox B, Jones D, Toner JP, Oehninger S,

  38. Muasher SJ. Cessation of gonadotropin-releasing hormone

  39. agonist therapy combined with high-dose gonadotropin

  40. stimulation yields favorable pregnancy results in low

  41. responders. Fertil Steril. 1998; 69:826â30

  42. Muchsin J, Yuslam EF, Hadi S, Muharam, Soegiharto S:

  43. tahun Pengalaman Pelayanan Program Bayi Tabung di

  44. Indonesia: Memperingati 20 tahun Program Bayi Tabung

  45. di Indonesia. Seminar Awam Perkembangan Mutakhir

  46. Penanganan Medis Masalah Ingin Anak. Jakarta, Mei 2008

Published
2009-11-01
How to Cite
1.
Soebijanto S. Prediction of pregnancy success rate through in vitro fertilization based on maternal age. Med J Indones [Internet]. 2009Nov.1 [cited 2020Oct.21];18(4):244-8. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/371
Section
Clinical Research