Prediction of pregnancy success rate through in vitro fertilization based on maternal age

  • Soegiharto Soebijanto
Keywords: pregnancy, in vitro fertilization


Aim To evaluate the correlation between the success of pregnancy through in vitro fertilization and maternal age.

Methods Assessment of pregnancy was performed in eight in vitro fertilization centers in Indonesia: Harapan Kita Pediatric and Obstetric Hospital from 1997 to 2001, and seven in vitro fertilization centers in Indonesia. Follicular induction was performed through the long protocol, short protocol and natural cycle. Insemination was performed through ICSI (intra cytoplasmic sperm injection) on petri dish. Spermatozoa were obtained through masturbation, testicular biopsy and epididimical biopsy. A successful pregnancy was indicated chemically, with the presence of fetal heart beat and the birth of a baby (take home baby).

Results There was a 34% pregnancy rate for the age group below 30 years, 33.75% for those between 31 and 35 years olds, and 26% for the age group 36 to 40 years old, and 8% for the age group above 40 years. Conclusion The higher the maternal age, the lower pregnancy rate. In other words, the higher the maternal age, the higher the rate of miscarriage. (Med J Indones 2009; 18: 244-8)


Piette C, de Mouzon J, Bachelot A, Spira A. In-vitro fertilization: infl uence of women's age on pregnancy rates. Hum Reprod. 1990; 5:56–9

Tucker MJ, Morton PC, Wright G, Ingargiola PE, Jones AE, Sweitzer CL. Factors affecting success with intracytoplasmic sperm injection. Reprod Fertil Dev. 1995; 7:229–36

Ashkenazi J, Orvieto R, Gold-Deutch R, Feldberg D, Dicker D, Voliovitch I, Ben Rafael Z. The impact of woman's age and sperm parameters on fertilization rates in IVF cycles. Eur J Obstet Gynecol Reprod Biol. 1996; 66:155–9

Hull MG, Fleming CF, Hughes AO, McDermott A. The age-related decline in female fecundity: a quantitative controlled study of implanting capacity and survival of individual embryos after in vitro fertilization. Fertil Steril. 1996; 65:783–90

Widra EA, Gindoff PR, Smotrich DB, Stillman RJ. Achieving multiple-order embryo transfer identifies women over 40 years of age with improved in vitro fertilization outcome. Fertil Steril. 1996; 65:103–8

Templeton A, Morris JK, Parslow W. Factors that affect outcome of in-vitro fertilisation treatment. Lancet. 1996; 348:1402–06

Legro RS, Shackleford DP, Moessner JM, Gnatuk CL, Dodson WC. ART in women 40 and over. Is the cost worth it? J Reprod Med. 1997; 42:76–82

te Velde ER, Pearson PL. The variability of female reproductive ageing. Hum Reprod Update. 2002; 8:141–54

van Hooff MH, Alberda AT, Huisman GJ, Zeilmaker GH, Leerentveld RA. Doubling the human menopausal gonadotrophin dose in the course of an in-vitro fertilization treatment cycle in low responders: a randomized study. Hum Reprod. 1993; 8:369–73

Tarlatzis BC, Zepiridis L, Grimbizis G, Bontis J. Clinical management of low ovarian response to stimulation for IVF: a systematic review. Hum Reprod Update. 2003; 9:61–76

Faber BM, Mayer J, Cox B, Jones D, Toner JP, Oehninger S, Muasher SJ. Cessation of gonadotropin-releasing hormone agonist therapy combined with high-dose gonadotropin stimulation yields favorable pregnancy results in low responders. Fertil Steril. 1998; 69:826–30

Muchsin J, Yuslam EF, Hadi S, Muharam, Soegiharto S: 20 tahun Pengalaman Pelayanan Program Bayi Tabung di Indonesia: Memperingati 20 tahun Program Bayi Tabung di Indonesia. Seminar Awam Perkembangan Mutakhir Penanganan Medis Masalah Ingin Anak. Jakarta, Mei 2008

How to Cite
Soebijanto S. Prediction of pregnancy success rate through in vitro fertilization based on maternal age. Med J Indones [Internet]. 2009Nov.1 [cited 2024Mar.3];18(4):244-8. Available from:
Clinical Research