Correlation of zinc plasma and IgM anti-PGL-1 levels among close contact of leprosy

  • Mohammad Z. Rahfiludin
  • Praba Ginandjar
  • Dina R. Pangestuti
DOI: https://doi.org/10.13181/mji.v21i3.500
Keywords: IgM anti PGL-1, close contact of leprosy, zinc plasma
Abstract viewed: 759 times
PDF downloaded: 558 times

Abstract

Background: Previous study showed leprosy patients have low zinc status. Yet the status of zinc in close-contact, which indicated by IgM anti-PGL1 level, have not determined. The aim of the study was to determine the association of zinc plasma and IgM anti-PGL-1 levels among close contact of leprosy patients in Indonesia.

Methods: This was an observational study. Subjects were 186 close-contact leprosy patients. Measurement of zinc plasma status used atomic absorption spectrophotometer while examination of IgM anti-PGL1 level used ELISA (Polyclonal rabbit anti human IgM/HRP/(Dako®).

Results: The average level of IgM anti-PGL1 and zinc plasma were 804 unit/mL (± 439.4) and 16.6 μmol/L (± 3.5) consecutively. There was significant correlation between zinc plasma and IgM anti-PGL1 (r = - 0.230; p = 0.002).

Conclusion: There is a significant correlation between zinc plasma and IgM anti-PGL1 in close contact of leprosy (Med J Indones. 2012;21:166-9)

Downloads

Download data is not yet available.

References

  1. Kerr-Pontes LR, Montenegro AC, Barreto ML, Werneck GL, Feldmeier H. Inequality and leprosy in Northeast Brazil: an ecological study. Int J Epidemiol. 2004;33:262-9.

  2. Ponnighaus JM, Fine PE, Sterne JA, Malema SS, Bliss L, Wilson RJ. Extended schooling and good housing conditions are associated with reduced risk of leprosy in rural Malawi. Int J Lepr Other Mycobact Dis.1994;62:345-52.

  3. Rahfiludin MZ, Nugraheni SA, Ametati H, Prihatin A, Purwaningsih E. The difference of anti phenolic glycolipid-1 (PGL-1) immunoglobulin-M (IgM) level and nutritional intake in subclinical leprosy patients who reside at home and in the orphanage. Med J Indones. 2007;16(4):233-6.

  4. Hotz C, Brown KH, editors. International Zinc Nutrition Consultative Group (IZiNCG) technical document #1: Tabel 2.Assosiation between zinc status and serological status in close contact of leprosyZinc StatusDeficientNormalTotalSero-positive32 (24.6 %)98 (75.4 %)130 (100.0 %)Sero-negative0 (0 %)56 (100.0 %)56 (100.0 %)assessment of the risk of zinc deficiency in populations and option for its control. Food Nutr Bull. 2004;25:S94-204.

  5. Prasad AS. Zinc: mechanisms of host defense. J Nutr. 2007;137(5):1345-9.

  6. Mathur NK, Sharma M, Mangal HN, Rai SM. Serum zinc level in subtypes of leprosy. Int J Lepr Other Mycobact Dis. 1984;52:327-30.

  7. George J, Bathia VN, Balakrishnan S, Ramu G. Serum zinc/copper ratio in subtypes of leprosy and effect of oral zinc therapy on reactional states. Int J Lepr Other Mycobact Dis. 1991;59:20-4.

  8. Saxena N, Sharma RP, Singh VS. Study of serum zinc level in leprosy. Indian J Lepr. 1988;60:556-61.

  9. Izumi S. Subclinical infection by Mycobacterium leprae. Int J Lepr Other Mycobact Dis. 1999;67(4 Suppl):S67-71.

  10. Barreto JG, Guimaraes LD, Leao MR, Ferreira DV, Lima RA, Salgado CG. Anti-PGL-1 seroepidemiology in leprosy cases: household contacts and school children from a hyperendemic municipality of the Brazilian Amazon. Lepr Rev. 2011;82:358-70.

  11. Sandström B. Diagnosis of zinc deficiency and excess in individuals and populations. Food Nutr Bull. 2001;22:133-7.

  12. Cuevas LE, Koyanagi A. Zinc and infection: a review. Ann Trop Paediatr. 2005;25:149-60.13. Gibson RS. Principles of nutritional assessment. 2nd ed. Oxford: Oxford University Press; 2005.

  13. Harboe M. Overview of host – parasite relation. In : Hastings RC. Leprosy. Churchil Livingstone. Edinburg; 1994.

  14. Scollard DM, Adams LB, Gillis TP, Krahenbuhl JP, Truman RW, Williams DL. The continuing challenges of leprosy. Clin Microbiol Rev. 2006;19(2):338-81.

  15. Maeda SM, Rotta O, Michalany NS, Camargo ZP, Sunderkötter C, Yamashita JT. Comparison between anti PGL-1 serology and Mitsuda reaction: clinical reading, microscopic findings and immunohistochemical analysis. Lepr Rev. 2003;74:263-74.

  16. Oskam L, Slim E, Bührer-Sékula S. Serology: recent developments, strengths, limitations and prospects: a state of the art overview. Lepr Rev. 2003;74:196-205.

  17. Solomons NW. Mild human zinc deficiency produces an imbalance between cell-mediated and humoral immunity. Nutr Rev. 1998;56(1): 27-8.

  18. Prasad AS. Effects of zinc deficiency on TH1 and TH2 cytokine shifts. J Infect Dis. 2000;182;S62-8.

  19. Rahfiludin MZ, Wirjatmadi B, Agusni I, Dahlan YP. Zinc supplementation could modulate T cell to maintain interleukin-2 level in seropositive contact of leprosy patients. Med J Indones. 2011;20:201-4.

  20. Haase H,Rink L. Functional significance of zinc – related signaling pathways in immune cells. Annu Rev Nutr. 2009;29:133-52.r = -0.230, Px2 = 0.002

  21. Chattree V, Khanna N, Rao DN. Alterations in T cell signal transduction by M. leprae antigens is associated with downregulation of second messengers PKC, calcium, calcineurin, MAPK and various transcription factors in leprosy patients. Mol Immunol. 2007;44(8):2066-77.

  22. Prasad AS. Zinc: role in immunity, oxidative stress and chronic inflammation. Curr Opin Clin Nutr Metab Care. 2009;12:646-52.

  23. Russell DG, Mwandumba HC, Rhoades EE. Mycobacterium and the coat of many lipids. J Cell Biol. 2002;158(3):421-6.

Published
2012-08-01
How to Cite
1.
Rahfiludin MZ, Ginandjar P, Pangestuti DR. Correlation of zinc plasma and IgM anti-PGL-1 levels among close contact of leprosy. Med J Indones [Internet]. 2012Aug.1 [cited 2024Jul.3];21(3):160-5. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/500
Issue
Vol. 21 No. 3 (2012): August
Section
Community Research

Copyright (c) 2012 Mohammad Z. Rahfiludin, Praba Ginandjar, Dina R. Pangestuti

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with Medical Journal of Indonesia agree to the following terms:

  1. Authors retain copyright and grant Medical Journal of Indonesia right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial License that allows others to remix, adapt, build upon the work non-commercially with an acknowledgment of the work’s authorship and initial publication in Medical Journal of Indonesia.
  2. Authors are permitted to copy and redistribute the journal's published version of the work non-commercially (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Medical Journal of Indonesia.