A case-control study of breast cancer among Japanese women in Tokyo

  • Kenji Wakai Department of Preventive Medicine, School of Medicine, Nagoya 466.
  • Yoshiyuki Ohno Department of Preventive Medicine, School of Medicine, Nagoya 466.
  • Sadao Suzuki Department of Preventive Medicine, School of Medicine, Nagoya 466.
  • Susumu Watanabe Department of Surgery, Cancer Institute Hospital, Tokyo 170.
  • Goi Sakamoto Department of Pathology, Cancer Institute Hospital, Tokyo 170.
  • Nakako Kubo Department of Public Health, Medical School, Nagoya City University, Nagoya 467.
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Abstract

Untuk meneliti faktor. risiko kanker payudara saat ini dilakukan penelitian kasus-kontrol pada rumah-sakit di Tokyo, dari tahun 1990 sampai 1991. Informasi mengenai faktor risiko potensial didapat dari kwesioner yang diisi sendiri oleh 5.084 pasien rawat jalan. Dari pasien tersebut didapat 300 kasus /canker payudara, dan dipilih 900 kontrol secara acak yang umunya sesuai. Temuan bermakna adalah: (a) semakin tinggijumlah kelahiran hidup, semakin kecil risikopada wanita pramenopause (risiko relatif (RR)yang disesuaikan untuk 3 atau lebih kelahiran hidup terhadap tanpa kelahiran hidup: 0,24; 95% interval kepercayaan (JK) : 0,08 - 0,65); (b)pada wanita pramenopause, siklus haid teratur meningkatkan risiko (RR yang disesuaikan: 2,50; 95% IK : 1,16-5,38), danpeningkatan lama siklus mengurangi risiko (P untuk kecenderungan linier < 0,05); (c)perokok masa kini mengalami peningkatan risiko (1,63; 1,11-2,39) untuk semua wanita, dan (2,73; 1,38-5,39) untuk wanita pasca menopause); (d) wanita yang kegemukan mengalami risiko lebih besar mendapat kanker payudara pasca menopause: RR yang disesuaikan untuk yang berbobot 70 kg atau lebih terhadap yang berbtH>ot 50 kg atau kurang adalah 4,82 (95% IK: 1,53-15,2); (e) semakin tua usia melahirkan anak pertama, semakin tinggi risiko kanker payudara pasca menopause (2,85; 1,16-6,99, dan 3,54; 1,03-12,2 untuk umur 30-34 dan 35 tahun atau lebih). Risiko kanker payudara pra menopause dan pascamenopause tidak berhubungan dengan riwayat kankerpayudara pada keluarga, riwayat penyakit payudara jinak, umur saat haid pertama dan menopause, la/etas kebiasaan minum alkohol dan tinggi badan. Abstract To explore the risk factors for recent female breast cancer, a hospital-based case-control study was conducted in Tokyo, from 1990 to 1991. Information on potential risk factors was obtained by a self-administered questionnaire from 5.084 out-patients. Of thepatients, 300 incident breast cancer cases were recruited, and 900 age-matched controls were randomly selected. Significant findings are: (a) the more the number of livebirths, the smaller the risk inpremenopausal women (adjusted relative risk (RR)for 3 or more births relative to none: 0.24; 95% confidence interval (CI): 0.08-0.65); (b) in premenopausal women, regular menstrual cycle increased the risk (adjusted RR: 2.50, 95% Cl: 1.16-5.38), and its increasing duration decreased the risk (Pfor linear trend <0.05); (c) current smokers experienced an increased risk (1.63, 1.11-2.39 for all women and (2.73; 1.38-5.39) for postmenopausal women; (d) obese women were al a greater risk of postmenopausal breast cancer: adjusted RR for those weighing 70 kg or more relative to those weighing 50 kg or less being 4.82 (95% Cl: 1.53-15.2); (e) the later the age at first livebirth, the higher the postmenopausal breast cancer risk (2.85; 1.16-6.99 and 3.54; 1.03-12.2 for ages of 30-34 and 35 years and more, respectively). Neither premenopausal nor postmenopausal breast cancer risk was independently associated withfamily history of breast cancer, history of benign breast disease, ages at menarche and menopause, lactation, drinking habits and body height. Keywords :breast cancer, risk factor, premenopausal, postmenopausal
Published
1995-07-01
How to Cite
1.
Wakai K, Ohno Y, Suzuki S, Watanabe S, Sakamoto G, Kubo N. A case-control study of breast cancer among Japanese women in Tokyo. Med J Indones [Internet]. 1995Jul.1 [cited 2022Jul.2];4(3):177-82. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/915
Section
Medical Journal of Indonesia

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