The status of probiotics supplementation during pregnancy
DOI:
https://doi.org/10.13181/mji.v24i2.1223Keywords:
preeclampsia, pregnancy, probiotics, prenatal supplementation, preterm laborAbstract
Probiotics have been known for their use in medical field for quite a long time. Strong evidences are now available for the use of probiotics in clinical setting. One of the current issues on this topic is the use of probiotics in pregnancy. Recent studies showed that probiotics may be safe and beneficial for prenatal supplementation. In this review, we highlighted several proven use of probiotics supplementation in pregnant women. A few selected strains of probiotics showed promising outcome to prevent preterm labor and preeclampsia, and to reduce atopic eczema but not asthma and wheezing, in offspring of women who had prenatal probiotics supplementation. The mechanism of action responsible for this effect is closely related to the regulation of T cells, although the exact pathways are not defined yet.
Downloads
References
Jay JM. Modern food microbiology. 6th ed. Maryland, USA: Aspen Publishers, Inc.; 2000. p. 3-5. http://dx.doi.org/10.1007/978-1-4615-4427-2_1
Johannsen E. Probiotic bacteria: their properties and mode of action. SA Fam Pract. 2003;45(3):36-8.
Kumar S. Textbook of Microbiology. 1st ed. Greater Noida, India: Jp Medical Pub; 2012. p. 784. http://dx.doi.org/10.5005/jp/books/11668
Caplice E, Fitzgerald GF. Food fermentations: role of microorganisms in food production and preservation. Int J Food Microbiol. 1999;50(1-2):131-49. http://dx.doi.org/10.1016/S0168-1605(99)00082-3
World Health Organization. Probiotics in food: Health and nutritional properties and guidelines for evaluation. Rome: World Health Organization/Food and Agriculture Organization of The United Nations; 2001.
Bäckhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science. 2005;307(5717):1915-20. http://dx.doi.org/10.1126/science.1104816
Dethlefsen L, McFall-Ngai M, Relman DA. An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature. 2007;449(7164):811-8. http://dx.doi.org/10.1038/nature06245
Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506-14. http://dx.doi.org/10.1038/nrgastro.2014.66
Pham M, Lemberg DA, Day AS. Probiotics: sorting the evidence from the myths. Med J Aust. 2008;188(5):304-8.
Charteris WP, Kelly PM, Morelli L, Collins JK. Selective detection, enumeration and identification of potentially probiotic Lactobacillus and Bifidobacterium species in mixed bacterial populations. Int J Food Microbiol. 1997;35(1):1-27. http://dx.doi.org/10.1016/S0168-1605(96)01222-6
Sazawal S, Hiremath G, Dhingra U, Malik P, Deb S, Black RE. Efficacy of probiotics in prevention of acute diarrhoea: a meta-analysis of masked, randomised, placebo-controlled trials. Lancet Infect Dis. 2006;6(6):374-82. http://dx.doi.org/10.1016/S1473-3099(06)70495-9
Hempel S, Newberry SJ, Maher AR, Wang Z, Miles JN, Shanman R, et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA. 2012;307(18):1959-69. http://dx.doi.org/10.1001/jama.2012.3507
Hoveyda N, Heneghan C, Mahtani KR, Perera R, Roberts N, Glasziou P. A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome. BMC Gastroenterol. 2009;9:15. http://dx.doi.org/10.1186/1471-230X-9-15
Fioramonti J, Theodorou V, Bueno L. Probiotics: what are they? What are their effects on gut physiology?. Best Pract Res Clin Gastroenterol. 2003;17(15):711-24. doi:10.1016/S1521-6918(03)00075-1
Elazab N, Mendy A, Gasana J, Vieira ER, Quizon A, Forno E. Probiotic administration in early life, atopy, and asthma: a meta-analysis of clinical trials. Pediatrics. 2013;132(3):e666-76. doi: 10.1542/peds.2013-0246d
Luoto R, Laitinen K, Nermes M, Isolauri E. Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study. Br J Nutr. 2010;103(12):1792-9. http://dx.doi.org/10.1017/S0007114509993898
Brantsæter AL, Myhre R, Haugen M, Myking S, Sengpiel V, Magnus P, et al. Intake of probiotic food and risk of preeclampsia in primiparous women: the Norwegian Mother and Child Cohort Study. Am J Epidemiol. 2011;174(7):807-15. http://dx.doi.org/10.1093/aje/kwr168
Yang Y, Guo Y, Kan Q, Zhou XG, Zhou XY, Li Y. A meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Braz J Med Biol Res. 2014;47(9):804-10. http://dx.doi.org/10.1590/1414-431X20143857
Boyle RJ, Robins-Browne RM, Tang ML. Probiotic use in clinical practice: what are the risks?. Am J Clin Nutr. 2006;83(6):1256-64.
Wagner RD, Pierson C, Warner T, Dohnalek M, Farmer J, Roberts L, et al. Biotherapeutic effects of probiotic bacteria on candidiasis in immunodeficient mice. Infect Immun. 1997;65(10):4165-72.
Lilly DM, Stillwell RH. Probiotics: growth-promoting factors produced by microorganisms. Science. 1965;147(3659):747-8. http://dx.doi.org/10.1126/science.147.3659.747
Fuller R. Probiotics in man and animals. J Appl Bacteriol. 1989;66(5):365-78. http://dx.doi.org/10.1111/j.1365-2672.1989.tb05105.x
Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995;125(6):1401-12.
Ohland CL, Macnaughton WK. Probiotic bacteria and intestinal epithelial barrier function. Am J Physiol Gastrointest Liver Physiol. 2010;298(6):G807-19. http://dx.doi.org/10.1152/ajpgi.00243.2009
World Health Organization/Food and Agriculture Organization of the United Nations. Guidelines for the evaluation of probiotics in food. Canada: FAO/WHO Working Group Report; 2002.
Brown M. Modes of action of probiotics: recent developments. J Anim Vet Adv. 2011;10(14):1895-900. http://dx.doi.org/10.3923/javaa.2011.1895.1900
Senok AC, Ismaeel AY, Botta GA. Probiotics: facts and myths. Clin Microbiol Infect. 2005;11(12):958-66. http://dx.doi.org/10.1111/j.1469-0691.2005.01228.x
Bermudez-Brito M, Plaza-Diaz J, Muñoz-Quezada S, Gómez-Llorente C, Gil A. Probiotic mechanisms of
action. Ann Nutr Metab. 2012;61(2):160-74. http://dx.doi.org/10.1159/000342079
Syndman DR. The safety of probiotics. Clin Infect Dis. 2008;46 Suppl 2:S104-11. http://dx.doi.org/10.1086/523331
Marteau P. Safety aspects of probiotic products. Scand J Nutr. 2001;45:22-4. http://dx.doi.org/10.3402/fnr.v45i0.1785
Elias J, Bozzo P, Einarson A. Are probiotics safe for use during pregnancy and lactation?. Can Fam Physician. 2011;57(3):299-301.
Sanders ME, Akkermans LM, Haller D, Hammerman C, Heimbach J, Hörmannsperger G, et al. Safety assessment of probiotics for human use. Gut microbes. 2010;1(3):164-85. http://dx.doi.org/10.4161/gmic.1.3.12127
Mack DR. D(-)-lactic acid-producing probiotics, D(-)-lactic acidosis and infants. Can J Gastroenterol. 2004;18(11):671-5.
Connolly E, Lönnerdal B. D(-)-Lactic acid-producing bacteria: Safe to use in infant formulas. NUTAfoods. 2004;3(3):37-49.
Htyte N, White L, Sandhu G, Jones J, Meisels I. An extreme and life-threatening case of recurrent D-lactate encephalopathy. Nephrol Dial Transplant. 2011;26(4):1432-5. http://dx.doi.org/10.1093/ndt/gfq829
Ku W, Lau DCY, Huen KF. Probiotics Provoked D-lactic acidosis in short bowel syndrome: case report and literature review. HK J Paediatr (new series). 2006;11:246-54.
Munakata S, Arakawa C, Kohira R, Fujita Y, Fuchigami T, Mugishima H. A case of D-lactic acid encephalopathy associated with use of probiotics. Brain Dev. 2010;32(8):691-4. http://dx.doi.org/10.1016/j.braindev.2009.09.024
Papagaroufalis K, Fotiou A, Egli D, Tran LA, Steenhout P. A randomized double blind controlled safety trial evaluating D-lactic acid production in healthy infants fed a Lactobacillus reuteri-containing formula. Nutr Metab Insights. 2014;7:19-27. doi: 10.4137/NMI.S14113
Rolain JM. Food and human gut as reservoirs of transferable antibiotic resistance encoding genes. Front Microbiol. 2013;4:173. http://dx.doi.org/10.3389/fmicb.2013.00173
Shazali N, Foo HL, Loh TC, Choe DW, Abdul Rahim R. Prevalence of antibiotic resistance in lactic acid bacteria isolated from the faeces of broiler chicken in Malaysia. Gut Pathog. 2014;6(1):1. http://dx.doi.org/10.1186/1757-4749-6-1
Gueimonde M, Sánchez B, G de Los Reyes-Gavilán C, Margolles A. Antibiotic resistance in probiotic bacteria. Front Microbiol. 2013;4:202. http://dx.doi.org/10.3389/fmicb.2013.00202
Devirgiliis C, Zinno P, Perozzi G. Update on antibiotic resistance in foodborne Lactobacillus and Lactococcus species. Front Microbiol. 2013;4:301. http://dx.doi.org/10.3389/fmicb.2013.00301
Dugoua JJ, Machado M, Zhu X, Chen X, Koren G, Einarson TR. Probiotic safety in pregnancy: a systematic review and meta-analysis of randomized controlled trials of Lactobacillus, Bifidobacterium, and Saccharomyces spp. J Obstet Gynaecol Can. 2009;31(6):542-52.
Allen SJ, Jordan S, Storey M, Thornton CA, Gravenor M, Garaiova I, et al. Dietary supplementation with Lactobacilli and Bifidobacteria is well tolerated and not associated with adverse events during late pregnancy and early infancy. J Nutr. 2010;140(3):483-8. http://dx.doi.org/10.3945/jn.109.117093
Sykes L, MacIntyre DA, Yap XJ, Ponnampalam S, Teoh TG, Bennett PR. Changes in the Th1:Th2 cytokine bias in pregnancy and the effects of the anti-inflammatory cyclopentenone prostaglandin 15-deoxy-Î?(12,14)-prostaglandin J2. Mediators Inflamm. 2012;2012:416739. http://dx.doi.org/10.1155/2012/416739
Saito S, Nakashima A, Shima T, Ito M. Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy. Am J Reprod Immunol. 2010;63(6):601-10. http://dx.doi.org/10.1111/j.1600-0897.2010.00852.x
Delcenserie V, Martel D, Lamoureux M, Amiot J, Boutin Y, Roy D. Immunomodulatory effects of probiotics in the intestinal tract. Curr Issues Mol Biol. 2008;10(1-2):37-54.
Tan M, Zhu JC, Du J, Zhang LM, Yin HH. Effects of probiotics on serum levels of Th1/Th2 cytokine and clinical outcomes in severe traumatic brain-injured patients: a prospective randomized pilot study. Crit Care. 2011;15(6):R290. http://dx.doi.org/10.1186/cc10579
who.int [Internet]. Preterm Birth. [update 2014 Nov; cited 2015 Feb]. Available from: http://www.who.int/mediacentre/factsheets/fs363/en/.
Krauss-Silva L, Moreira MEL, Alves MB, Braga A, Camacho KG, Batista MRR, et al. A randomised controlled trial of probiotics for the prevention of spontaneous preterm delivery associated with bacterial vaginosis: preliminary results. Trials. 2011;12:239. http://dx.doi.org/10.1186/1745-6215-12-239
Vitali B, Cruciani F, Baldassarre ME, Capursi T, Spisni E, Valerii MC, et al. Dietary supplementation with probiotics during late pregnancy: outcome on vaginal microbiota and cytokine secretion. BMC Microbiol. 2012;12:236. http://dx.doi.org/10.1186/1471-2180-12-236
Othman M, Neilson JP, Alfirevic Z. Probiotics for preventing preterm labour. Cochrane Database Syst Rev. 2007(1):Cd005941. http://dx.doi.org/10.1002/14651858.cd005941.pub2
Myhre R, Brantsæter AL, Myking S, Gjessing HK, Sengpiel V, Meltzer HM, et al. Intake of probiotic food and risk of spontaneous http://dx.doi.org/10.3945/ajcn.110.004085
Yang S, Li W, Challis JR, Reid G, Kim SO, Bocking AD. Probiotic Lactobacillus rhamnosus GR-1 supernatant prevents lipopolysaccharide-induced preterm birth and reduces inflammation in pregnant CD-1 mice. Am J Obstet Gynecol. 2014;211(1):44.e1-e12. http://dx.doi.org/10.1016/j.ajog.2014.01.029
Yeganegi M, Watson CS, Martins A, Kim SO, Reid G, Challis JR, et al. Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor. Am J Obstet Gynecol. 2009;200(5):532.e1-8. http://dx.doi.org/10.1016/j.ajog.2008.12.032
Yeganegi M. The effect of Lactobacillus rhamnosus GR-1 supernatant on cytokine production and prostaglandins in gestational tissues [thesis]. Ann Arbor: University of Toronto (Canada); 2010.
Dong JY, Szeto IM, Makinen K, Gao Q, Wang J, Qin LQ, et al. Effect of probiotic fermented milk on blood pressure: a meta-analysis of randomised controlled trials. Br J Nutr. 2013;110(7):1188-94. http://dx.doi.org/10.1017/S0007114513001712
Doege K, Grajecki D, Zyriax BC, Detinkina E, Zu Eulenburg C, Buhling KJ. Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood--a meta-analysis. Br J Nutr. 2012;107(1):1-6. http://dx.doi.org/10.1017/S0007114511003400
Pelucchi C, Chatenoud L, Turati F, Galeone C, Moja L, Bach JF, et al. Probiotics supplementation during pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis. Epidemiology. 2012;23(3):402-14. http://dx.doi.org/10.1097/EDE.0b013e31824d5da2
Bertelsen RJ, Brantsæter AL, Magnus MC, Haugen M, Myhre R, Jacobsson B, et al. Probiotic milk consumption in pregnancy and infancy and subsequent childhood allergic diseases. J Allergy Clin Immunol. 2014;133(1):165-71. http://dx.doi.org/10.1016/j.jaci.2013.07.032
Ouwehand AC. Antiallergic effects of probiotics. J Nutr. 2007;137(3 Suppl 2):794S-7S.
Kalliomäki M, Antoine JM, Herz U, Rijkers GT, Wells JM, Mercenier A. Guidance for substantiating the evidence for beneficial effects of probiotics: prevention and management of allergic diseases by probiotics. J Nutr. 2010;140(3):713S-21S. http://dx.doi.org/10.3945/jn.109.113761
Pali-Schöll I, Renz H, Jensen-Jarolim E. Update on allergies in pregnancy, lactation, and early childhood. J Allergy Clin Immunol. 2009;123(5):1012-21. http://dx.doi.org/10.1016/j.jaci.2009.01.045
Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. http://dx.doi.org/10.1016/j.jaci.2012.09.003
Blümer N, Sel S, Virna S, Patrascan CC, Zimmermann S, Herz U, et al. Perinatal maternal application of Lactobacillus rhamnosus GG suppresses allergic airway inflammation in mouse offspring. Clin Exp Allergy. 2007;37(3):348-57. http://dx.doi.org/10.1111/j.1365-2222.2007.02671.x
Feleszko W, Jaworska J, Rha RD, Steinhausen S, Avagyan A, Jaudszus A, et al. Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma. Clin Exp Allergy. 2007;37(4):498-505. http://dx.doi.org/10.1111/j.1365-2222.2006.02629.x
Kim HJ, Kim YJ, Lee SH, Kang MJ, Yu HS, Jung YH, et al. Effects of Lactobacillus rhamnosus on asthma with an adoptive transfer of dendritic cells in mice. J Appl Microbiol. 2013;115(3):872-9. http://dx.doi.org/10.1111/jam.12268
Yu J, Jang SO, Kim BJ, Song YH, Kwon JW, Kang MJ, et al. The effects of Lactobacillus rhamnosus on the prevention of asthma in a murine model. Allergy Asthma Immunol Res. 2010;2(3):199-205. http://dx.doi.org/10.4168/aair.2010.2.3.199
Azad MB, Coneys JG, Kozyrskyj AL, Field CJ, Ramsey CD, Becker AB, et al. Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis. BMJ. 2013;347:f6471. http://dx.doi.org/10.1136/bmj.f6471
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with Medical Journal of Indonesia agree to the following terms:
- Authors retain copyright and grant Medical Journal of Indonesia right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial License that allows others to remix, adapt, build upon the work non-commercially with an acknowledgment of the work’s authorship and initial publication in Medical Journal of Indonesia.
- Authors are permitted to copy and redistribute the journal's published version of the work non-commercially (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Medical Journal of Indonesia.