A glance at molecular mechanisms underlying cisplatin-induced nephrotoxicity and possible renoprotective strategies: a narrative review

  • Bashar Adi Wahyu Pandhita Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Deliana Nur Ihsani Rahmi Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Nielda Kezia Sumbung Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Bernardino Matthew Waworuntu Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Regina Puspa Utami Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
  • Melva Louisa Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia https://orcid.org/0000-0002-9451-0380
  • Vivian Soetikno Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Keywords: cisplatin, kidney, kidney injury, oxidative stress

Abstract

Cisplatin is a platinum-based drug that is usually used for the treatment of many carcinomas. However, it comes with several devastating side effects, including nephrotoxicity. Cisplatin toxicity is a very complex process, which is exacerbated by the accumulation of cisplatin in renal tubular cells via passive diffusion and transporter-mediated processes. Once cisplatin enters these cells, it induces the formation of reactive oxygen species that cause cellular damage, including DNA damage, inflammation, and eventually cell death. On a small scale, these damages can be mitigated by cellular antioxidant defense mechanism. However, on a large scale, such as in chemotherapy, this defense mechanism may fail, resulting in nephrotoxicity. The current article reviews the molecular mechanisms underlying cisplatin-induced nephrotoxicity and possible renoprotective strategies to determine novel therapeutic interventions for alleviating this toxicity.

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Published
2019-10-04
How to Cite
1.
Pandhita BAW, Rahmi DNI, Sumbung NK, Waworuntu BM, Utami RP, Louisa M, Soetikno V. A glance at molecular mechanisms underlying cisplatin-induced nephrotoxicity and possible renoprotective strategies: a narrative review. Med J Indones [Internet]. 2019Oct.4 [cited 2024Feb.26];28(3):292-9. Available from: https://mji.ui.ac.id/journal/index.php/mji/article/view/2690
Section
Review Article

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