The status of probiotics supplementation during pregnancy

  • Noroyono Wibowo Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta
  • Johanes C. Mose Department of Obstetric and Gynecology, Faculty of Medicine, Padjajaran University, Bandung
  • Made K. Karkata Department of Obstetric and Gynecology, Faculty of Medicine, Udayana University, Bali
  • Bangun T. Purwaka Department of Obstetric and Gynecology, Faculty of Medicine, Airlangga University, Surabaya
  • Herman Kristanto Department of Obstetric and Gynecology, Faculty of Medicine, Diponegoro University, Semarang
  • Maisuri T. Chalid Department of Obstetric and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar
  • Yusrawati Yusrawati Department of Obstetric and Gynecology, Faculty of Medicine, Andalas University, Padang
  • Makmur Sitepu Department of Obstetric and Gynecology, Faculty of Medicine, University of Sumatera Utara, Medan
  • Juneke J. Kaeng Department of Obstetric and Gynecology, Faculty of Medicine, Sam Ratulangi University, Medan
  • Nuswil Bernolian Department of Obstetric and Gynecology, Faculty of Medicine, Sriwijaya University, Palembang
  • Damar Prasmusinto Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta
  • Rima Irwinda Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta
Keywords: preeclampsia, pregnancy, probiotics, prenatal supplementation, preterm labor


Probiotics have been known for their use in medical field for quite a long time. Strong evidences are now available for the use of probiotics in clinical setting. One of the current issues on this topic is the use of probiotics in pregnancy. Recent studies showed that probiotics may be safe and beneficial for prenatal supplementation. In this review, we highlighted several proven use of probiotics supplementation in pregnant women. A few selected strains of probiotics showed promising outcome to prevent preterm labor and preeclampsia, and to reduce atopic eczema but not asthma and wheezing, in offspring of women who had prenatal probiotics supplementation. The mechanism of action responsible for this effect is closely related to the regulation of T cells, although the exact pathways are not defined yet.


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How to Cite
Wibowo N, Mose JC, Karkata MK, Purwaka BT, Kristanto H, Chalid MT, Yusrawati Y, Sitepu M, Kaeng JJ, Bernolian N, Prasmusinto D, Irwinda R. The status of probiotics supplementation during pregnancy. Med J Indones [Internet]. 2015Jun.28 [cited 2024Mar.1];24(2):120-30. Available from:
Review Article