Serum specific IgE responses to inhalant allergens sensitization

Iris Rengganis, Suriani Alimuddin, Agus J. Susanto



DOI: http://dx.doi.org/10.13181/mji.v26i3.1909

Abstract


Background: Serum specific immunoglobulin E (ssIgE) sensitization to common inhalant allergens has not been studied in Indonesia. This study aimed to evaluate specific IgE production of common inhalant allergens in patients with asthma and/or allergic rhinitis in Jakarta, Indonesia.

Methods: This was a cross-sectional study in adult patients with respiratory allergy from September to December 2016 at Cipto Mangunkusumo Hospital, Jakarta. Patients were included if they showed at least one positive skin prick test (SPT) to environmental allergens. Serum specific IgE was assayed by using multiple allergosorbent methods. Inhalant allergens tested were dust mites, pollen, cockroach, animal dander, and mould. Serum IgE level more than 0.35 kU/L was considered positive.

Results: One hundred subjects were enrolled (76% women). Dust mites made up 75% of sensitization, followed by cat/dog (31%), cockroach (27%), pollen (24%), and mould (6%). Almost all patients sensitized to cockroach, pollen, cat/dog epithelia and mould were also co-sensitized with dust mites. Twenty two percent of patients were negative to all tested allergens.

Conclusion: IgE-sensitization to inhalant allergens varies widely in respiratory allergic patients. House dust and storage mites are the most common allergens. About one-fifth of the subjects did not show specific-IgE sensitization. Thus, this test should always be combined with SPT to diagnose allergy.


Keywords


allergic rhinitis; asthma; house dust mites; IgE sensitization; specific IgE

Full Text:

PDF

References


  1. De Vos G. Skin testing versus serum-specific IgE testing: which is better for diagnosing aeroallergen sensitization and predicting clinical allergy? Curr Allergy Asthma Rep. 2014;14:430. https://doi.org/10.1007/s11882-014-0430-z
  2. Pawankar R, Canonica GW, Holgate ST, Lockey RF, Blaiss M. The world allergy organization (WAO) white book on allergy: Update 2013;WAO:87–92.
  3. Baratawidjaja IR, Baratawidjaja PP, Darwis A, Hwe LS, Tim CF, Wah LB, et al. Prevalence of allergic sensitization to regional inhalant among allergic patient in Jakarta, Indonesia. Asian Pac J Allergy Immunol.1999;17:9–12.
  4. Sundaru H. House dust mite allergen level and allergen sensitization as risk factor for asthma among student in Central Jakarta. Med J Indones. 2006;15:55–9. https://doi.org/10.13181/mji.v15i1.213
  5. Rengganis I, Hartana A, Guhardja E, Djauzi S, Budiarti S. Pollen sensitivity among respiratory allergic patients. Majalah Kedokteran Indonesia. 2008;58:327–34. Indonesian.
  6. Calabria CW, Dietrich J, Hagan L. Comparison of serum-specific IgE (ImunoCAP) and skin prick test result for 53 inhalant allergens in patients with chronic rhinitis. Allergy Asthma Proc. 2009;3:386–90. https://doi.org/10.2500/aap.2009.30.3258
  7. Canonica GW, Ansotegui IJ, Pawankar R, Schmid-Grendelmeier P, van Hage M, Baena-Cagnani CE, et al. A WAO – ARIA – GA2LEN consensus document on molecular-based allergy diagnostics. WAO J. 2013;6:17. https://doi.org/10.1186/1939-4551-6-17
  8. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008;63 (Suppl 86):8–160. https://doi.org/10.1111/j.1398-9995.2007.01620.x
  9. Thomas WR. Geography of house dust mite allergens. Asian Pac J Allergy Immunol. 2010;28:211–24.
  10. Sidenius KE, Hallas TE, Poulsen LK, Mosbech H. House dust mites and their allergens in Danish mattresses – results from a p.
  11. Chiang CH, Wu KM, Wu CP, Yan HC, Perng WC. Evaluation of risk factors for asthma in Taipei City. J Chin Med Assoc 2005;68:204–9. https://doi.org/10.1016/S1726-4901(09)70208-4
  12. Fernandez-Caldas E, Lockey RF. Blomia tropicalis, a mite whose time has come. Allergy. 2004;59:1161–4. https://doi.org/10.1111/j.1398-9995.2004.00727.x
  13. Tsai JJ, Wu HH, Shen HD, Hsu EL, Wang SR. Sensitization to Blomia tropicalis among asthmatic patients in Taiwan. Int Arch Allergy Immunol. 1998;115:144–9. https://doi.org/10.1159/000023894
  14. Lai CL, Shyur SD, Wu CY, Chang CL, Chu SH. Specific IgE to 5 different major house dust mites among asthmatic children. Acta Paediatr Taiwan 2002;43:265–70.
  15. Thind BB, Clarke PG. The occurrence of mites in cereal-based foods destined for human consumption and possible consequences of infestation. Exp Appl Acarol 2001;25:203–15. https://doi.org/10.1023/A:1010647519044
  16. Musken H, Franz JT, Wahl R, Paap A, Cromwell O, Masuch G, Bergmann KC. Sensitization to different mite species in German farmers: clinical aspects. J Investig Allergol Clin Immunol 2000;10:346–51.
  17. Mullen GR, OConnor BM. Mites (Acari). In: Mullen GR, Durden LA. Medical and Veterinary Entomology. 2nd Ed. Academic Press (Elsevier Imprint), 2009.
  18. Jeong KY, Kim WK, Lee JS, Lee J, Lee IY, Kim KE, Park JW, Hong CS, Ree HI, Yong TS. Immunoglobulin E reactivity of recombinant allergen Tyr p 13 from Tyrophagus putrescentiae homologous to fatty acid binding protein. Clin Diagn Lab Immunol. 2005;12:581–5. https://doi.org/10.1128/CDLI.12.5.581-585.2005
  19. Ferraroni NR, Oliveira S, Ferraroni JJ. Prevalence of Sensitization to the Storage Mite Acarus Siro in Middle-East of Brazil J Allergy Clin Immunol 2013;131:AB163. http://dx.doi.org/10.1016/j.jaci.2012.12.1242
  20. Pomés A, Chruszcz M, Gustchina A, Wlodawer A. Interfaces between allergen structure and diagnosis: Know your epitopes. Curr Allergy Asthma Rep. 2015 Apr;15(8):506. https://doi.org/10.1007/s11882-014-0506-9





Copyright (c) 2017 Iris Rengganis, Suriani Alimuddin, Agus Joko Susanto

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

All articles and issues in Medical Journal of Indonesia have unique DOI number registered in Crossref.
 
Romeo
 
http://mji.ui.ac.id/journal/index.php/mji/pages/view/stat
Unique Visitors