Serum specific IgE responses to inhalant allergens sensitization

  • Iris Rengganis Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta
  • Suriani Alimuddin Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makassar
  • Agus J. Susanto Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Surakarta
DOI: https://doi.org/10.13181/mji.v26i3.1909
Keywords: allergic rhinitis, asthma, house dust mites, IgE sensitization, specific IgE
Abstract viewed: 1754 times
PDF downloaded: 800 times
HTML downloaded: 142 times
EPUB downloaded: 128 times

Abstract

Background: Serum specific immunoglobulin E (ssIgE) sensitization to common inhalant allergens has not been studied in Indonesia. This study aimed to evaluate specific IgE production of common inhalant allergens in patients with asthma and/or allergic rhinitis in Jakarta, Indonesia.

Methods: This was a cross-sectional study in adult patients with respiratory allergy from September to December 2016 at Cipto Mangunkusumo Hospital, Jakarta. Patients were included if they showed at least one positive skin prick test (SPT) to environmental allergens. Serum specific IgE was assayed by using multiple allergosorbent methods. Inhalant allergens tested were dust mites, pollen, cockroach, animal dander, and mould. Serum IgE level more than 0.35 kU/L was considered positive.

Results: One hundred subjects were enrolled (76% women). Dust mites made up 75% of sensitization, followed by cat/dog (31%), cockroach (27%), pollen (24%), and mould (6%). Almost all patients sensitized to cockroach, pollen, cat/dog epithelia and mould were also co-sensitized with dust mites. Twenty two percent of patients were negative to all tested allergens.

Conclusion: IgE-sensitization to inhalant allergens varies widely in respiratory allergic patients. House dust and storage mites are the most common allergens. About one-fifth of the subjects did not show specific-IgE sensitization. Thus, this test should always be combined with SPT to diagnose allergy.

Author Biographies

Iris Rengganis, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta

Department of Internal Medicine, 

Division of Allergy and Clinical Immunology 

Suriani Alimuddin, Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makassar

Department of Internal Medicine, 

Division of Allergy and Clinical Immunology 

Agus J. Susanto, Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Surakarta

Department of Internal Medicine, 

Division of Allergy and Clinical Immunology 

References

  1. De Vos G. Skin testing versus serum-specific IgE testing: which is better for diagnosing aeroallergen sensitization and predicting clinical allergy? Curr Allergy Asthma Rep. 2014;14:430. https://doi.org/10.1007/s11882-014-0430-z

  2. Pawankar R, Canonica GW, Holgate ST, Lockey RF, Blaiss M. The world allergy organization (WAO) white book on allergy: Update 2013;WAO:87-92.

  3. Baratawidjaja IR, Baratawidjaja PP, Darwis A, Hwe LS, Tim CF, Wah LB, et al. Prevalence of allergic sensitization to regional inhalant among allergic patient in Jakarta, Indonesia. Asian Pac J Allergy Immunol.1999;17:9â12.

  4. Sundaru H. House dust mite allergen level and allergen sensitization as risk factor for asthma among student in Central Jakarta. Med J Indones. 2006;15:55-9. https://doi.org/10.13181/mji.v15i1.213

  5. Rengganis I, Hartana A, Guhardja E, Djauzi S, Budiarti S. Pollen sensitivity among respiratory allergic patients. Majalah Kedokteran Indonesia. 2008;58:327-34. Indonesian.

  6. Calabria CW, Dietrich J, Hagan L. Comparison of serum-specific IgE (ImunoCAP) and skin prick test result for 53 inhalant allergens in patients with chronic rhinitis. Allergy Asthma Proc. 2009;3:386-90. https://doi.org/10.2500/aap.2009.30.3258

  7. Canonica GW, Ansotegui IJ, Pawankar R, Schmid- Grendelmeier P, van Hage M, Baena-Cagnani CE, et al. A WAO – ARIA – GA2LEN consensus document on molecular-based allergy diagnostics. WAO J. 2013;6:17. https://doi.org/10.1186/1939-4551-6-17

  8. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A et al. Allergic rhinitis and its impact on asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 2008;63 (Suppl 86):8-160. https://doi.org/10.1111/j.1398-9995.2007.01620.x

  9. Thomas WR. Geography of house dust mite allergens. Asian Pac J Allergy Immunol. 2010;28:211-24.

  10. Sidenius KE, Hallas TE, Poulsen LK, Mosbech H. House dust mites and their allergens in Danish mattresses – results from a p.

  11. Chiang CH, Wu KM, Wu CP, Yan HC, Perng WC. Evaluation of risk factors for asthma in Taipei City. J Chin Med Assoc 2005;68:204-9. https://doi.org/10.1016/S1726-4901(09)70208-4

  12. Fernandez-Caldas E, Lockey RF. Blomia tropicalis, a mite whose time has come. Allergy. 2004;59:1161-4. https://doi.org/10.1111/j.1398-9995.2004.00727.x

  13. Tsai JJ, Wu HH, Shen HD, Hsu EL, Wang SR. Sensitization to Blomia tropicalis among asthmatic patients in Taiwan. Int Arch Allergy Immunol. 1998;115:144-9. https://doi.org/10.1159/000023894

  14. Lai CL, Shyur SD, Wu CY, Chang CL, Chu SH. Specific IgE to 5 different major house dust mites among asthmatic children. Acta Paediatr Taiwan 2002;43:265-70.

  15. Thind BB, Clarke PG. The occurrence of mites in cereal-based foods destined for human consumption and possible consequences of infestation. Exp Appl Acarol 2001;25:203-15. https://doi.org/10.1023/A:1010647519044

  16. Musken H, Franz JT, Wahl R, Paap A, Cromwell O, Masuch G, Bergmann KC. Sensitization to different mite species in German farmers: clinical aspects. J Investig Allergol Clin Immunol 2000;10:346-51.

  17. Mullen GR, OConnor BM. Mites (Acari). In: Mullen GR, Durden LA. Medical and Veterinary Entomology. 2nd Ed. Academic Press (Elsevier Imprint), 2009.

  18. Jeong KY, Kim WK, Lee JS, Lee J, Lee IY, Kim KE, Park JW, Hong CS, Ree HI, Yong TS. Immunoglobulin E reactivity of recombinant allergen Tyr p 13 from Tyrophagus putrescentiae homologous to fatty acid binding protein. Clin Diagn Lab Immunol. 2005;12:581-5. https://doi.org/10.1128/CDLI.12.5.581-585.2005

  19. Ferraroni NR, Oliveira S, Ferraroni JJ. Prevalence of Sensitization to the Storage Mite Acarus Siro in Middle-East of Brazil J Allergy Clin Immunol 2013;131:AB163. http://dx.doi.org/10.1016/j.jaci.2012.12.1242

  20. Pomés A, Chruszcz M, Gustchina A, Wlodawer A. Interfaces between allergen structure and diagnosis: Know your epitopes. Curr Allergy Asthma Rep. 2015 Apr;15(8):506. https://doi.org/10.1007/s11882-014-0506-9

Published
2017-11-27
How to Cite
1.
Rengganis I, Alimuddin S, Susanto AJ. Serum specific IgE responses to inhalant allergens sensitization. Med J Indones [Internet]. 2017Nov.27 [cited 2024Apr.20];26(3):224-8. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/1909
Issue
Vol. 26 No. 3 (2017): September
Section
Clinical Research

Copyright (c) 2017 Iris Rengganis, Suriani Alimuddin, Agus J. Susanto

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Authors who publish with Medical Journal of Indonesia agree to the following terms:

  1. Authors retain copyright and grant Medical Journal of Indonesia right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial License that allows others to remix, adapt, build upon the work non-commercially with an acknowledgment of the work’s authorship and initial publication in Medical Journal of Indonesia.
  2. Authors are permitted to copy and redistribute the journal's published version of the work non-commercially (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Medical Journal of Indonesia.