Serum specific IgE responses to inhalant allergens sensitization

  • Iris Rengganis Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta
  • Suriani Alimuddin Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makassar
  • Agus J. Susanto Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Surakarta
Keywords: allergic rhinitis, asthma, house dust mites, IgE sensitization, specific IgE
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Abstract

Background: Serum specific immunoglobulin E (ssIgE) sensitization to common inhalant allergens has not been studied in Indonesia. This study aimed to evaluate specific IgE production of common inhalant allergens in patients with asthma and/or allergic rhinitis in Jakarta, Indonesia.

Methods: This was a cross-sectional study in adult patients with respiratory allergy from September to December 2016 at Cipto Mangunkusumo Hospital, Jakarta. Patients were included if they showed at least one positive skin prick test (SPT) to environmental allergens. Serum specific IgE was assayed by using multiple allergosorbent methods. Inhalant allergens tested were dust mites, pollen, cockroach, animal dander, and mould. Serum IgE level more than 0.35 kU/L was considered positive.

Results: One hundred subjects were enrolled (76% women). Dust mites made up 75% of sensitization, followed by cat/dog (31%), cockroach (27%), pollen (24%), and mould (6%). Almost all patients sensitized to cockroach, pollen, cat/dog epithelia and mould were also co-sensitized with dust mites. Twenty two percent of patients were negative to all tested allergens.

Conclusion: IgE-sensitization to inhalant allergens varies widely in respiratory allergic patients. House dust and storage mites are the most common allergens. About one-fifth of the subjects did not show specific-IgE sensitization. Thus, this test should always be combined with SPT to diagnose allergy.

Author Biographies

Iris Rengganis, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta

Department of Internal Medicine, 

Division of Allergy and Clinical Immunology 

Suriani Alimuddin, Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makassar

Department of Internal Medicine, 

Division of Allergy and Clinical Immunology 

Agus J. Susanto, Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Surakarta

Department of Internal Medicine, 

Division of Allergy and Clinical Immunology 

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Published
2017-11-27
How to Cite
1.
Rengganis I, Alimuddin S, Susanto AJ. Serum specific IgE responses to inhalant allergens sensitization. Med J Indones [Internet]. 2017Nov.27 [cited 2019Nov.22];26(3):224-8. Available from: http://mji.ui.ac.id/journal/index.php/mji/article/view/1909
Section
Clinical Research